Cell Nucleus-Targeting Zwitterionic Carbon Dots

An innovative nucleus-targeting zwitterionic carbon dot (CD) vehicle has been developed for anticancer drug delivery and optical monitoring. The zwitterionic functional groups of the CDs introduced by a simple one-step synthesis using beta-alanine as a passivating and zwitterionic ligand allow cytoplasmic uptake and subsequent nuclear translocation of the CDs. Moreover, multicolor fluorescence improves the accuracy of the CDs as an optical code. The CD-based drug delivery system constructed by non-covalent grafting of doxorubicin, exhibits superior antitumor efficacy owing to enhanced nuclear delivery in vitro and tumor accumulation in vivo, resulting in highly effective tumor growth inhibition. Since the zwitterionic CDs are highly biocompatible and effectively translocated into the nucleus, it provides a compelling solution to a multifunctional nanoparticle for substantially enhanced nuclear uptake of drugs and optical monitoring of translocation.open

Kinetics of toluene methylation over silica modified HZSM-5 zeolites

334-340Kinetics of toluene alkylation with methanol over silica modified HZSM-5 catalyst under experimental conditions that are close to envisaged industrial conditions are studied. Of the several possible kinetic models tested and compared, a simple power law model is found satisfactory in predicting toluene conversions and p-xylene selectivities. However, further studies with a comprehensive experimental program, is suggested for investigating the numerous side reactions and to account for a large number of by-products observed. </span