The Road Home Program: An Efficient Model of PTSD Treatment in Veterans

This thesis details my experiences at Rush University’s Road Home Program during the summer of 2021. The Road Home Program is an intensive treatment program for veterans suffering from PTSD. It is unique from conventional PTSD treatments in that it provides the equivalent of six months of treatment in just two weeks. The Road Home Program approaches PTSD in a comprehensive way by implementing a variety of therapies and supplemental treatments to veterans. These therapies include Cognitive Processing Therapy (CPT), Mindfulness Based Resiliency Training (MBRT), Dialectical Behavioral Therapy (DBT), and Art Therapy. The supplemental treatments include cognitive seminars, acupuncture, and individual consultations with clinicians. During the summer of 2021 I watched the drastic change that occurred in veterans as they journeyed through the Road Home Program. At the end of two weeks, veterans experienced less intense PTSD symptoms as well as symptoms of comorbidities such as anxiety, depression, and suicidal ideation. Some of these veterans no longer met the diagnostic criteria for PTSD upon treatment completion. In addition, there has been research, done by the Road Home Program, that supports that these effects are retained up to a year after treatment (Held et al., 2020). I was inspired by the Road Home Program and how drastically it changed veterans’ lives in such a short amount of time. Moreover, my goal in writing this thesis is to share with others the hope and potential that exists for veterans at The Road Home Program. I argue that greater consideration and research be allocated towards intensive treatment programs such as the Road Home Program. Most veterans who attend the Road Home Program attest that it saved their lives and as such, this program merits greater consideration from the PTSD treating community in America. 1.Held, P., Zalta, A.K., Smith, D.L., Bagley, J.M., Steigerwald, V.L., Boley, R.A., Miller, M., Brennan, M.B., Van Horn, R., & Pollack, M.H. (2020). Maintenance of treatment gains up to 12-months following a three-week cognitive processing therapy-based intensive PTSD treatment programme for veterans. European Journal of Psychotraumatology, 11(1), doi: 10.1080/20008198.2020.178932

Are Particles in Advection-Dominated Accretion Flows Thermal?

We investigate the form of the momentum distribution function for protons and electrons in an advection-dominated accretion flow (ADAF). We show that for all accretion rates, Coulomb collisions are too inefficient to thermalize the protons. The proton distribution function is therefore determined by the viscous heating mechanism, which is unknown. The electrons, however, can exchange energy quite efficiently through Coulomb collisions and the emission and absorption of synchrotron photons. We find that for accretion rates greater than \sim 10^{-3} of the Eddington accretion rate, the electrons have a thermal distribution throughout the accretion flow. For lower accretion rates, the electron distribution function is determined by the electron's source of heating, which is primarily adiabatic compression. Using the principle of adiabatic invariance, we show that an adiabatically compressed collisionless gas maintains a thermal distribution until the particle energies become relativistic. We derive a new, non-thermal, distribution function which arises for relativistic energies and provide analytic formulae for the synchrotron radiation from this distribution. Finally, we discuss its implications for the emission spectra from ADAFs.Comment: 29 pages (Latex), 3 Figures. Submitted to Ap

A VLA Search for the Geminga Pulsar: A Bayesian Limit on a Scintillating Source

We derive an upper limit of 3 mJy (95% confidence) for the flux density at 317 MHz of the Geminga pulsar (J0633+1746). Our results are based on 7 hours of fast-sampled VLA data, which we averaged synchronously with the pulse period using a period model based on CGRO/EGRET gamma-ray data. Our limit accounts for the fact that this pulsar is most likely subject to interstellar scintillations on a timescale much shorter than our observing span. Our Bayesian method is quite general and can be applied to calculate the fluxes of other scintillated sources. We also present a Bayesian technique for calculating the flux in a pulsed signal of unknown width and phase. Comparing our upper limit of 3 mJy with the quoted flux density of Geminga at 102 MHz, we calculate a lower limit to its spectral index of 2.7. We discuss some possible reasons for Geminga's weakness at radio wavelengths, and the likelihood that many of the unidentified EGRET sources are also radio-quiet or radio-weak Geminga-like pulsars.Comment: 27 pages, including figures. Published in Ap

Etablierung der homöopathischen Mastitistherapie in einem biologisch-dynamisch wirtschaftenden Milcherzeugerbetrieb unter Berücksichtigung ökologischer, epidemiologischer und ökonomischer Gesichtspunkte.

6 Summary The dairy cow mastitis as a disease with an immense economic impact is widely spread in organic as well as in conventional farms. Due to the lack of alternatives to antibiotic treatment, most therapeutical measures are based on antibiotics even in organic farms and against common regulations. In contrary to these procedures the EU regulations (Council Regulation EC 1804/99)as well as the consumer’s anticipation demand the possibly lowest levels of residual charges of dairy products and environment. A two and a half year study in a bio-dyn dairy herd in Brandenburg (Germany) with 300 dairy cows suffering from udder health problems was conducted to evaluate if clinical mastitis in dairy cows is to control successfully with homeopathic remedies to minimize antibiotic treatment. To assess the efficacy of the homeopathic treatment the investigations are made using a double blind placebo controlled study design (RCCT). Using a predetermined treatment protocol and a certain diagnostic pattern to match right remedies in the sense of the homeopathic remedy pictures, the intention of the chosen treatment schedule was to provide a very transparent concept which can be used also by unexperienced veterinarians. For treatment of acute mastitis the following remedies were used: Phytolacca D6, Bryonia D6 , Echinacea D6 and Belladonna D6. Aconitum D6 was added in case of fever at the beginning of disease. Cases of chronical and subclinical mastitis were treated by Echinacea D6, Phytolacca D6 and Hepar sulfuris D8. In the first part of the study nearly all mastitis cases were treated only with homeopathics avoiding antibiotics strictly. The unsatisfying results in this part lead to a modification in the second part in which in case of certain infections (S.aureus, Sc.spp.) a limited use of antibiotics was admitted. Furthermore, selected udders with subclinical and chronical infections with these kind of bacteria were dried off antibiotically. Simultaneously the farmer was engaged to intensify the efforts to optimize preventive and environmental measures in the herd. In the second part of the study 126 cows (148 quarters) suffered from clinical mastitis (Verum: n=60; Placebo: n=66). The cure rates were nearly identical. In the whole population the clinical cure rate (CCR) immediately after treatment was 95%, 7 to 8 weeks after treatment 65%. The 107 clinically affected quarters which were infected by pathogenic bacteria showed a bacteriological cure rate (BCR) of 55% each and a complete bacterio-cytological cure rate (BCCR) of 35% and 40% after 4-5 weeks and 7-8 weeks after treatment, respectively. During the observation time of 8 weeks a total of 12 cows in each of the treatment groups produced a homologous recurrent infection. 6 cows in the verum group and 4 cows in the placebo group developed a new infection in one of the other quarters. The treatment results seems to be satisfying while the enhanced but still not optimized environmental conditions in the herd are possibly responsible for the high amount of new infections and recurrences. Looking at the results of the study at all, the use of antibiotics could be decreased by 75% due to the therapy management (in spite of the change of it because of unsatisfying results) in combination with preventive measures. Additionally the herd udder health could be increased. So the mean herd somatic cell count decreased by 75.000 somatic cells/ml to 165.000 somatic cells/ml. Furthermore, the milk yield increased by 250 kg to 6.500 kg/cow/year. The count of infections with S. aureus in the herd decreased dramatically. The decreasing input of antibiotics in mastitis therapy in the project farm lead to a decrease of 36.000 kg antibiotically loaded milk compared to a hypothetic conventional mastitis management. Furthermore, the omission of withdrawal times after homeopathic treatment resulted in a benefit of additional production milk of 25.000 kg. The antibiotics minimizing therapy concept of the second part of this investigation which could be evaluated under practice conditions can be recommended for other farms too if simultaneous herd prevention measures can be assured by the farm manager to ensure good preconditions for the convalescence of the cows. The cure rates after placebo are unexpected high. Due to these results it is profoundly debatable whether the strategies of conventional therapy of bovine mastitis are suitable to ensure herd udder health. It should be evaluated which part of the cure rate is amounted by self cure and which other factors have an effect on the healing. The nearly identical cure rates in both treatment groups do not allow the proof of homeopathic efficacy at all. Indeed, comparing the bacteriologically caused mastitis cases (107 quarters), there is a significantly higher cure rate in the verum group (p < 0.05)

Discovery of a Hard X-Ray Source, SAX J0635+0533, in the Error Box of the Gamma-Ray Source 2EG 0635+0521

We have discovered an x-ray source, SAX J0635+0533, with a hard spectrum within the error box of the GeV gamma-ray source in Monoceros, 2EG J0635+0521. The unabsorbed x-ray flux is 1.2*10^-11 erg cm^-2 s^-1 in the 2-10 keV band. The x-ray spectrum is consistent with a simple powerlaw model with absorption. The photon index is 1.50 +/- 0.08 and we detect emission out to 40 keV. Optical observations identify a counterpart with a V-magnitude of 12.8. The counterpart has broad emission lines and the colors of an early B type star. If the identification of the x-ray/optical source with the gamma-ray source is correct, then the source would be a gamma-ray emitting x-ray binary.Comment: Accepted to the Astrophysical Journal, 8 page

Soil organic carbon pool changes following land-use conversions

Includes bibliographical references (pages 1131-1132).Carbon (C) can be sequestered in the mineral soil after the conversion of intensively cropped agricultural fields to more extensive land uses such as afforested and natural succession ecosystems. Three land-use treatments from the long-term ecological research site at Kellogg biological station in Michigan were compared with a nearby deciduous forest. Treatments included a conventionally tilled cropland, a former cropland afforested with poplar for 10 years and an old field (10 years) succession. We used soil aggregate and soil organic matter fractionation techniques to isolate C pools that (1) have a high potential for C storage and (2) accumulate C at a fast rate during afforestation or succession. These fractions could serve as sensitive indicators for the total change in C content due to land-use changes. At the mineral soil surface (0–7 cm), afforesting significantly increased soil aggregation to levels similar to native forest. However, surface soil (0–7 cm) C did not follow this trend: soil C of the native forest site (22.9 t C ha-1) was still significantly greater than the afforested (12.6 t C ha-1) and succession (15.4 t C ha-1) treatments. However, when the 0–50 cm soil layer was considered, no differences in total soil C were observed between the cropland and the poplar afforested system, while the successional system increased total soil C (0–50 cm) at a rate of 0.786 t C ha-1 yr-1. Afforested soils sequestered C mainly in the fine intra-aggregate particulate organic matter (POM) (53–250 μm), whereas the successional soils sequestered C preferentially in the mineral-associated organic matter and fine intra-aggregate POM C pools

High-Energy Gamma-Ray Observations of Two Young, Energetic Radio Pulsars

We present results of Compton Gamma-Ray Observatory EGRET observations of the unidentified high-energy gamma-ray sources 2EG J1049-5847 (GEV J1047-5840, 3EG J1048-5840) and 2EG J1103-6106 (3EG J1102-6103). These sources are spatially coincident with the young, energetic radio pulsars PSRs B1046-58 and J1105-6107, respectively. We find evidence for an association between PSR B1046-58 and 2EG J1049-5847. The gamma-ray pulse profile, obtained by folding time-tagged photons having energies above 400 MeV using contemporaneous radio ephemerides, has probability of arising by chance of 1.2E-4 according to the binning-independent H-test. A spatial analysis of the on-pulse photons reveals a point source of equivalent significance 10.2 sigma. Off-pulse, the significance drops to 5.8 sigma. Archival ASCA data show that the only hard X-ray point source in the 95% confidence error box of the gamma-ray source is spatially coincident with the pulsar within the 1' uncertainty (Pivovaroff, Kaspi & Gotthelf 1999). The double peaked gamma-ray pulse morphology and leading radio pulse are similar to those seen for other gamma-ray pulsars and are well-explained in models in which the gamma-ray emission is produced in charge-depleted gaps in the outer magnetosphere. The inferred pulsed gamma-ray flux above 400 MeV, (2.5 +/- 0.6) x 10E-10 erg/cm^2/s, represents 0.011 +/- 0.003 of the pulsar's spin-down luminosity, for a distance of 3 kpc and 1 sr beaming. For PSR J1105-6107, light curves obtained by folding EGRET photons using contemporaneous radio ephemerides show no significant features. We conclude that this pulsar converts less than 0.014 of its spin-down luminosity into E > 100 MeV gamma-rays beaming in our direction (99% confidence), assuming a distance of 7 kpc, 1 sr beaming and a duty cycle of 0.5.Comment: Accepted for publication in the Astrophysical Journa

Nova saznanja o neuralnoj regulaciji nosne sluznice kod ljudi

Nasal mucosa is innervated by multiple subsets of nociceptive, parasympathetic and sympathetic nerves. These play carefully coordinated roles in regulating glandular, vascular and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent recognition of distinct classes of nociceptive nerves with unique patterns of sensory receptors that include seven transmembrane G-protein coupled receptors, new families of transient receptor potential and voltage and calcium gated ion channels, and combinations of neurotransmitters that can be modulated during inflammation by neurotrophic factors has revolutionized our understanding of the complexity and subtlety of nasal innervation. These findings may provide a rational basis for responses to air temperature changes, culinary and botanical odorants ("aromatherapy"), and inhaled irritants in conditions as diverse as idiopathic nonallergic rhinitis, occupational rhinitis, hyposmia, and multiple chemical sensitivity.Nosnu sluznicu prožimaju višestruke podskupine nociceptivnih, parasimpatičkih i simpatičkih živaca koji imaju podrobno usklađene uloge u reguliranju žljezdanih, žilnih i drugih procesa. Ove funkcije su presudne za čišćenje i ovlaživanje zraka iz okoline prije negoli se udahne u pluća. Naše shvaćanje složene i fine naravi inervacije nosne sluznice radikalno se mijenja nedavnim prepoznavanjem različitih vrsta nociceptivnih živaca s jedinstvenim obrascima senzornih receptora koji obuhvaćaju sedam transmembranskih receptora vezanih s G-proteinom, nove porodice prolaznog receptorskog potencijala i napona te kalcijem ograničene (gated) ionske kanale i kombinacije neurotransmitora koje tijekom upale mogu mijenjati neurotropni čimbenici. Ovi nalazi mogli bi pružiti razumnu osnovu za odgovore na promjene u temperaturi zraka, kulinarske i botaničke mirise ("aromaterapija") i udisajne iritante u uvjetima tako ranovrsnim kao što su idiopatski nealergijski rinitis, profesionalni rinitis, hiposmija i višestruka kemijska osjetljivost