The Relationship Between Job Characteristics and Retirement

We study the influence of job characteristics on prospective retirement as measured by the probability of working past age 62 or 65. The characteristics fall into three broad classes: physical and mental requirements, job flexibility including employer accomodation to older workers, and financial aspects such as pensions and health care insurance. Using data from the Health and Retirement Survey, we find that physical and mental job requirements have a rather small influence on prospective retirement, whereas measures of job flexibility and financial aspects of the job are important determinants.

Coping with loss: cell adaptation to cytoskeleton disruption

Unravelling the role of cytoskeleton regulators may be complicated by adaptations to experimental manipulations. In this issue of Developmental Cell, Cerikan et al. (2016) reveal how acute effects of DOCK6 RhoGEF depletion on RAC1 and CDC42 activation are reversed over time by compensatory mechanisms that re-establish cellular homeostasis

Evaluation of Subjective Probability Distributions in the HRS

In the Health and Retirement Survey respondents were asked about the chances they would live to 75 or to 85, and the chances they would work after age 62 or 65. We analyze the responses to determine if they behave like probabilities, if their averages are close to average probabilities in the population, and if they have correlations with other variables that are similar to correlations with actual outcomes. We find that generally they do behave like probabilities and they do aggregate. Most remarkable, however, is that they covary with other variables in the same way actual outcomes vary with the variables. For example, smokers give lower probabilities of living to 75 than nonsmokers. We conclude that these measures of subjective probabilities have great potential use in models of intertemporal decision making under uncertainty.

A Statute in Particularly Serious Need of Reinterpretation: The Particularly Serious Crime Exception to Withholding of Removal

Withholding of removal provides that a deportable alien may avoid removal if she can show that it is more likely than not that her life or freedom will be threatened if she is removed to a particular country. Aliens are not eligible for withholding of removal, however, if they are found to have been convicted of a particularly serious crime as defined by 8 U.S.C. § 1231(b)(3)(B)(ii). Although Congress provided a per se definition of a particularly serious crime in the statute, the majority of U.S. courts of appeals have held that immigration judges can also declare crimes that do not fit this statutory definition to be particularly serious. This Note argues that the majority interpretation is incorrect and that the minority interpretation, which only allow crimes that fit the statutory definition to be declared particularly serious, is correct. This Note additionally argues that a further finding that an alien poses an ongoing danger to the community should be required before an alien is denied withholding of removal

CIO Symposium

The CIO Symposium at AMCIS 2021 provides academics with a unique opportunity to get insights directly from IT Executives to prepare their students for the challenges and opportunities necessary to succeed in today’s dynamic environment. This symposium is also a great way for academics to evaluate the practical implications of their research by engaging with leaders. Moderator: - Michael Wade, Ph.D. Panelists: - Michael McGarry – VP and US Life Insurance CIO, Genworth - Diane Schnupp – Executive Vice President and Chief Information Officer, Kinsale Capital Group - Alexandre Synnett – Executive Vice President and Chief Technology Officer, Caisse de Depot & Placement D Quebec (CDPQ)

A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids

Reactive oxygen species act as important second messengers in cell signaling and homeostasis through the oxidation of protein thiols. However, the dynamic nature of protein oxidation and the lack of sensitivity of existing molecular probes have hindered our understanding of such reactions; therefore, new tools are required to address these challenges. We designed a bifunctional variant of the strained bicyclo[6.1.0]nonyne (BCN-E-BCN) that enables the tagging of intracellular protein sulfenic acids for biorthogonal copper-free click chemistry. In validation studies, BCN-E-BCN binds the sulfenylated form of the actin-severing protein cofilin, while mutation of the cognate cysteine residues abrogates its binding. BCN-E-BCN is cell permeable and reacts rapidly with cysteine sulfenic acids in cultured cells. Using different azide-tagged conjugates, we demonstrate that BCN-E-BCN can be used in various applications for the detection of sulfenylated proteins. Remarkably, cycloaddition of an azide-tagged fluorophore to BCN-E-BCN labelled proteins produced in vivo can be visualized by fluorescence microscopy to reveal their subcellular localization. These findings demonstrate a novel and multifaceted approach to the detection and trapping of sulfenic acids