187 research outputs found
God\u27s Design and Phonemic Awareness: What is phonemic awareness, what is phonics, and what does God have to do with it?
Phonemic awareness is the foundation for a child’s literacy development. God’s initial interaction with man after creation, through the spoken word, bestows authority on oral language. Manipulation of language begins in infancy and continues throughout one’s life. Teachers need to understand what phonemic awareness entails in order to develop and assess a child’s development in this area
God\u27s Design and Phonemic Awareness
Phonemic awareness is the foundation for a child\u27s literacy development. God\u27s initial interation with man after creation, through the spoken word, bestows authority on oral language. Manipulation of language begins in infancy and continues throughout one\u27s life. Teachers need to understand what phonemic awareness entails in order to develop and assess a child\u27s development in this area
Teacher Candidate Success on State Mandated Professional Tests: One Predictive Measure
This article presents a predictive model using teacher candidates\u27 Grade Point Average (GPA) and its relationship to candidate success on two professional state mandated teaching exams. The 196 subjects for the study were traditional undergraduate teacher education candidates at a major university in Virginia. Specifically, the majority of courses were presented in the face-to-face setting, with a few online courses available. Subject selection was based upon completion of the Virginia Communication Literacy Assessment (VCLA) and the Virginia Reading Assessment (VRA). Data were collected for three consecutive years. Analysis of the relationship between GPA and scores on the VRA and VCLA demonstrated a statistically significant relationship between (a) GPA and mean score on the VRA, and (b) GPA and mean score on the VCLA. These results indicate that better overall performance in the classroom, as measured by grade point average (GPA), produces a higher mean score on both professional assessments
Developing a Comprehensive, Interdisciplinary Concussion Program
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.There has been a growing trend of local and national coverage of and interest in concussion injuries over the past 2 decades. Increasing public concern over potential catastrophic and unknown long-term effects of sports-related concussion injuries has led to an acknowledgment of the strong public health need for addressing all concussion injuries, regardless of mechanism of injury. In efforts to address this need for concussion prevention and management, both in sports and nonsports, The University of Kansas Health System initiated the interdisciplinary Center for Concussion Management program in 2012. The program was created as a virtual clinic concept and includes voluntary participation from various providers across the institution, limited budget, and space obstacles. Since its inception, the program has continued to operate as its initial design of a multidisciplinary team model outside the sole ownership of 1 department, and has expanded to include education and outreach to local and regional schools and groups.The University of Kansas (KU) One University Open Access Author Fund sponsored jointly by the KU ProvostKU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research and managed jointly by the Libraries at the Medical Center and KU - Lawrenc
Breast cancer risk and hormone receptor status in older women by parity, age of first birth, and breastfeeding: a case-control study.
BACKGROUND: Early age at first birth and multiparity reduce the risk of estrogen receptor-progesterone receptor (ERPR)-positive breast cancer, whereas breastfeeding reduces the risk of both ERPR-positive and ERPR-negative cancers. METHODS: We used multivariable logistic regression analysis to investigate whether age at first birth ( or =25 years) and breastfeeding (ever/never) modify the long-term effect of parity on risk of ERPR-positive and ERPR-negative cancer using 1,457 incident breast cancer cases and 1,455 controls ages > or =55 years who participated in the Women's Contraceptive and Reproductive Experiences Study. RESULTS: Women who gave birth before age 25 years had a 36% reduced risk of breast cancer compared with nulligravida that was not observed for women who started their families at an older age (P(heterogeneity) = 0.0007). This protective effect was restricted to ERPR-positive breast cancer (P(heterogeneity) = 0.004). Late age at first birth increased the risk of ERPR-negative cancers. Additional births reduced the risk of ERPR-positive cancers among women with an early first birth (P(trend) = 0.0001) and among women who breastfed (P(trend) = 0.004) but not among older mothers or those who never breastfed. In women with a late first birth who never breastfed, multiparity was associated with increased risk of breast cancer. CONCLUSIONS: These findings suggest that the effect of parity on a woman's long-term risk of breast cancer is modified by age at first full-term pregnancy and possibly by breastfeeding
Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women
Abstract
Introduction
The association of breast cancer patients’ mortality with estrogen receptor (ER) status (ER + versus ER-) has been well studied. However, little attention has been paid to the relationship between the quantitative measures of ER expression and mortality.
Methods
We evaluated the association between semi-quantitative, immunohistochemical staining of ER in formalin-fixed paraffin-embedded breast carcinomas and breast cancer-specific mortality risk in an observational cohort of invasive breast cancer in 681 white women and 523 black women ages 35-64 years at first diagnosis of invasive breast cancer, who were followed for a median of 10 years. The quantitative measures of ER examined here included the percentage of tumor cell nuclei positively stained for ER, ER Histo (H)-score, and a score based on an adaptation of an equation presented by Cuzick and colleagues, which combines weighted values of ER H-score, percentage of tumor cell nuclei positively stained for the progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) results. This is referred to as the ER/PR/HER2 score.
Results
After controlling for age at diagnosis, race, study site, tumor stage, and histologic grade in multivariable Cox proportional hazards regression models, both percentage of tumor cell nuclei positively stained for ER (P trend = 0.0003) and the ER H-score (P trend = 0.0004) were inversely associated with breast cancer-specific mortality risk. The ER/PR/HER2 score was positively associated with breast cancer-specific mortality risk in women with ER + tumor (P trend = 0.001). Analyses by race revealed that ER positivity was associated with reduced risk of breast cancer-specific mortality in white women and black women. The two quantitative measures for ER alone provided additional discrimination in breast cancer-specific mortality risk only among white women with ER + tumors (both P trend ≤ 0.01) while the ER/PR/HER2 score provided additional discrimination for both white women (P trend = 0.01) and black women (P trend = 0.03) with ER + tumors.
Conclusions
Our data support quantitative immunohistochemical measures of ER, especially the ER/PR/HER2 score, as a more precise predictor for breast cancer-specific mortality risk than a simple determination of ER positivity
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