A Paradise Lost in Translation? Traduction de la parodie et traduction parodique dans la littérature Japonaise

Dans plusieurs textes parodiques publiés au Japon au cours des années ’80 et ’90, la traduction a été à la fois un thème et un moyen pour véhiculer la relecture de certaines œuvres canoniques de la modernité. Il s’agit cependant d’un corpus de travaux qui n’a pas été suffisamment exploité pour enrichir la réflexion théorique sur les questions de l’affirmation de la valeur et la circulation du « capitale littéraire ». Le rapprochement entre ces deux procédés de transposition littéraire – parodie et traduction, apparemment antinomiques - s’est montré fécond dans la réflexion sur la littérature postmoderne qui a mis en relief le rapport à la fois mimétique et transformateur avec le texte source. Dans cette étude on montrera ce rapport à travers un corpus de textes de la littérature japonaise contemporaine (Ogino Anna, Watashi no aidokusho, 1991 ; Shimizu Yoshinori, Ese monogatari, 1991) jamais publiés en traduction ; il s’agit d’œuvres où les deux opérations coexistent (traductions parodiques et parodies de traductions) et qui peuvent être considéré aussi comme des traductions intralinguistiques qui actualisent les œuvres canoniques pour un public nouveau

Molecular dynamics recipes for genome research

Molecular dynamics (MD) simulation allows one to predict the time evolution of a system of interacting particles. It is widely used in physics, chemistry and biology to address specific questions about the structural properties and dynamical mechanisms of model systems. MD earned a great success in genome research, as it proved to be beneficial in sorting pathogenic from neutral genomic mutations. Considering their computational requirements, simulations are commonly performed on HPC computing devices, which are generally expensive and hard to administer. However, variables like the software tool used for modeling and simulation or the size of the molecule under investigation might make one hardware type or configuration more advantageous than another or even make the commodity hardware definitely suitable for MD studies. This work aims to shed lights on this aspect

Medullary thyroid carcinoma

Introduction: Medullary thyroid carcinoma (MTC) constitutes approximately 5–10% of all thyroid cancers. Although the tumor forms in the thyroid, it doesn’t originate from thyroid cells, but from the C cells or parafollicular cells which produce and release a hormone called calcitonin (CT). Starting from the second half of the 1900s, MTC was progressively studied and defined. Areas covered: This study aims to analyze the history, clinical presentation and biological behavior of MTC, bio-humoral and instrumental diagnosis, molecular profiling, genetic screening, preoperative staging and instrumental procedures, indispensable in expert and dedicated hands, such as high-resolution ultrasonography, CT-scan, MRI and PET/TC. We examine recommended and controversial surgical indications and procedures, prophylactic early surgery and multiple endocrine neoplasia surgery. Also, we discuss pathological anatomy classification and targeted therapies. The role of serum CT is valued both as undisputed and constant preoperative diagnostic marker, obscuring cytology and as early postoperative marker that predicts disease persistence. Expert opinion: With a complete preoperative study, unnecessary or useless, late and extended interventions can be reduced in favor of tailored surgery that also considers quality of life. Finally, great progress has been made in targeted therapy, with favorable impact on survival

Multifaceted enrichment analysis of RNA-RNA crosstalk reveals cooperating micro-societies in human colorectal cancer

Alterations in the balance of mRNA and microRNA (miRNA) expression profiles contribute to the onset and development of colorectal cancer. The regulatory functions of individual miRNA-gene pairs are widely acknowledged, but group effects are largely unexplored. We performed an integrative analysis of mRNA–miRNA and miRNA–miRNA interactions using high-throughput mRNA and miRNA expression profiles obtained from matched specimens of human colorectal cancer tissue and adjacent non- tumorous mucosa. This investigation resulted in a hypernetwork-based model, whose functional back- bone was fulfilled by tight micro-societies of miR- NAs. These proved to modulate several genes that are known to control a set of significantly enriched cancer-enhancer and cancer-protection biological processes, and that an array of upstream regulatory analyses demonstrated to be dependent on miR-145, a cell cycle and MAPK signalling cascade master regulator. In conclusion, we reveal miRNA-gene clusters and gene families with close functional relationships and highlight the role of miR-145 as potent upstream regulator of a complex RNA–RNA crosstalk, which mechanistically modulates several signalling path- ways and regulatory circuits that when deranged are relevant to the changes occurring in colorectal carcinogenesis