Linkage signals obtained with microsatellite (Micro), Illumina SNP (Illum) and Affymetrix SNP (Affy) maps on selected chromosomes

<p><b>Copyright information:</b></p><p>Taken from "Genome-wide linkage analysis of age at onset of alcohol dependence: a comparison between microsatellites and single-nucleotide polymorphisms"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S12-S12.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866818.</p><p></p

Plot of highest linkage signals on 22 chromosomes using microsatellites (Micro, black), Illumina (Illum, dotted) and Affymetrix (Affy, red) maps

<p><b>Copyright information:</b></p><p>Taken from "Genome-wide linkage analysis of age at onset of alcohol dependence: a comparison between microsatellites and single-nucleotide polymorphisms"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S12-S12.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866818.</p><p></p

Parameter estimates from segregation analysis of ovarian cancer in 1919 proband-ascertained pedigrees.

†<p>Parameters in square brackets were fixed at the values indicated; <b>^‡</b>M indicates Mendelian transmission: τ_AA = 1.0, τ_AB = 0.5, τ_BB = 0.0.</p>§<p>The meaning of γ parameters is as follows: ^γ_md represents mother/daughter residual association; ^γ_ss represents sister/sister residual association; <b>^*</b>Parameter hit bound; <b>^§</b>No. of independent parameters: (no. of parameters in model) – (no. of parameters fixed at boundary) – (no. of dependent and or fixed parameters); Chi-square is defined as (-2 ln L) of the data under the specific hypothesis minus (−2 ln L) of the data under the general model.</p

Distributions of numbers of nuclear families and inheritance vector bit in the 1919 pedigrees.

<p>Distributions of numbers of nuclear families and inheritance vector bit in the 1919 pedigrees.</p

Distribution of ovarian cancer affection status among relationship pairs.

<p>Distribution of ovarian cancer affection status among relationship pairs.</p

Plot showing distributions of number of generations in the 1919 pedigrees.

<p>Plot showing distributions of number of generations in the 1919 pedigrees.</p

Distribution of relationship types in the study sample.

‡<p>Values in parentheses indicate number of dummy individuals used for the purpose of pedigree connections and who were not considered in analysis. These dummies were mostly pedigree founders.</p

Characteristics of the participants, WEB study controls, Erie and Niagara Counties, 1996–2001^a.

<p>Characteristics of the participants, WEB study controls, Erie and Niagara Counties, 1996–2001<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0156450#t001fn001" target="_blank">^a</a>.</p