Altered monocyte activation markers in Tourette's syndrome: a case-control study

Background: Infections and immunological processes are likely to be involved in the pathogenesis of Tourette's syndrome (TS). To determine possible common underlying immunological mechanisms, we focused on innate immunity and studied markers of inflammation, monocytes, and monocyte-derived cytokines. Methods: In a cross-sectional study, we used current methods to determine the number of monocytes and levels of C-reactive protein (CRP) in 46 children, adolescents, and adult patients suffering from TS and in 43 healthy controls matched for age and sex. Tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), soluble CD14 (sCD14), IL1-receptor antagonist (IL1-ra), and serum neopterin were detected by immunoassays. Results: We found that CRP and neopterin levels and the number of monocytes were significantly higher in TS patients than in healthy controls. Serum concentrations of TNF-alpha, sIL1-ra, and sCD14 were significantly lower in TS patients. All measured values were within normal ranges and often close to detection limits. Conclusions: The present results point to a monocyte dysregulation in TS. This possible dysbalance in innate immunity could predispose to infections or autoimmune reactions

Der deutsche Aufsatz in der Volksschule

von Rud. Mat

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Franjo Pećarić, bisernica : drugi dio diplomskog ispita

Drugi dio diplomskog ispita Franje Pećarića (bisernica), studenta Muzičke akademije Sveučilišta u Zagrebu. Ispit je održan u Domu INA Rafinerije nafte Sisak 5. 7. 2021. Klavirska pratnja: Brigita Vilč, umj. sur. Mentor: doc. Siniša Leopold; komentor: Veljko Valentin Škorvaga, v. pred. Program: 1. Ludwig van Beethoven: Romanca u F-duru, op. 50; 2. Bohuslav Martinů: Prva sonata za flautu i klavir (Allegro moderato – Adagio – Allegro poco moderato); 3. Rudolf Matz: Elegija; 4. Tomislav Uhlik: Ólafur og álfamær; 5. Tomislav Uhlik: Hej ti, Wisło, modra rzeko; 6. Herman Beeftink: Spring; 7. Tivadar Nachèz: Nouvelle danse tzigane, op. 3