1 research outputs found
Synthesis of 3‑(Hetero)aryl Tetrahydropyrazolo[3,4‑<i>c</i>]pyridines by Suzuki–Miyaura Cross-Coupling Methodology
A new
synthetic route to 3-(heteroaryl) tetrahydropyrazoloÂ[3,4-<i>c</i>]Âpyridines has been developed that uses the Suzuki–Miyaura
cross-coupling of a triflate <b>6</b> with (hetero)Âaryl
boronic acids or esters. Using PdÂ(OAc)<sub>2</sub> and XPhos or an
XPhos precatalyst, a diverse range of substituents at the C3 position
of the tetrahydropyrazoloÂ[3,4-<i>c</i>]Âpyridine
skeleton were prepared. The use of pivaloyloxymethyl and benzyl protection
also offers the potential to differentially functionalize the pyrazole
and tetrahydropyridine nitrogens