Recurrent Outbursts and Jet Ejections Expected in Swift J1644+57: Limit-Cycle Activities in a Supermassive Black Hole

The tidal disruption event by a supermassive black hole in Swift J1644+57 can trigger limit-cycle oscillations between a supercritically accreting X-ray bright state and a subcritically accreting X-ray dim state. Time evolution of the debris gas around a black hole with mass M=10^{6} {\MO} is studied by performing axisymmetric, two-dimensional radiation hydrodynamic simulations. We assumed the $\alpha$-prescription of viscosity, in which the viscous stress is proportional to the total pressure. The mass supply rate from the outer boundary is assumed to be ${\dot M}_{\rm supply}=100L_{\rm Edd}/c^2$, where $L_{\rm Edd}$ is the Eddington luminosity, and $c$ is the light speed. Since the mass accretion rate decreases inward by outflows driven by radiation pressure, the state transition from a supercritically accreting slim disk state to a subcritically accreting Shakura-Sunyaev disk starts from the inner disk and propagates outward in a timescale of a day. The sudden drop of the X-ray flux observed in Swift J1644+57 in August 2012 can be explained by this transition. As long as ${\dot M}_{\rm supply}$ exceeds the threshold for the existence of a radiation pressure dominant disk, accumulation of the accreting gas in the subcritically accreting region triggers the transition from a gas pressure dominant Shakura-Sunyaev disk to a slim disk. This transition takes place at $t {\sim}~50/({\alpha}/0.1)$ days after the X-ray darkening. We expect that if $\alpha > 0.01$, X-ray emission with luminosity $\gtrsim 10^{44}$ ${\rm erg}{\cdot}{\rm s}^{-1}$ and jet ejection will revive in Swift J1644+57 in 2013--2014.Comment: 6 pages, 4 figures, accepted for publication in PASJ Letter

楷書筆順の規範形成に関する歴史的研究

内容の要約広島大学(Hiroshima University)博士(教育学)Doctor of Philosophy in Educationdoctora

A Fundamental Research on Reconstruction of Shosha Education

The present time is the information age. The environment which surrounds the act of writing a character, in such a time is changing a lot. Moreover, the sense of values is also changing a lot. The purpose of the act of writing a character has changed from the public purpose to the private purpose. Shosha education is asked for reconstruction in response to such a time background. Also in order to follow change of society, it is necessary to advance reexamination of the purpose of Japanese language education immediately. So, in this paper, arrangement of the point of argument for reexamining the purpose of shosha education is tried, being based on the point of a future time. Moreover, it proposes about the directivity and viewpoint of development of a shosha-education curriculum

Amelioration of diabetes in NOD by additive Aire

Tissue-specific autoimmune diseases are assumed to arise through malfunction of two checkpoints for immune tolerance: defective elimination of autoreactive T cells in the thymus and activation of these T cells by corresponding autoantigens in the periphery. However, evidence for this model and the outcome of such alterations in each or both of the tolerance mechanisms have not been sufficiently investigated. We studied these issues by expressing human AIRE (huAIRE) as a modifier of tolerance function in NOD mice wherein the defects of thymic and peripheral tolerance together cause type I diabetes (T1D). Additive huAIRE expression in the thymic stroma had no major impact on the production of diabetogenic T cells in the thymus. In contrast, huAIRE expression in peripheral antigen-presenting cells (APCs) rendered the mice resistant to T1D, while maintaining other tissue-specific autoimmune responses and antibody production against an exogenous protein antigen, because of the loss of Xcr1+ dendritic cells, an essential component for activating diabetogenic T cells in the periphery. These results contrast with our recent demonstration that huAIRE expression in both the thymic stroma and peripheral APCs resulted in the paradoxical development of muscle-specific autoimmunity. Our results reveal that tissue-specific autoimmunity is differentially controlled by a combination of thymic function and peripheral tolerance, which can be manipulated by expression of huAIRE/Aire in each or both of the tolerance mechanisms

An Individual-Based Diploid Model Predicts Limited Conditions Under Which Stochastic Gene Expression Becomes Advantageous

Recent studies suggest the existence of a stochasticity in gene expression (SGE) in many organisms, anditsnon-negligible effecton their phenotype and fitness. To date, however, how SGE affects the key parameters of population genetics are not well understood. SGE can increase the phenotypic variation and act as a load for individuals, if they are at the adaptive optimum in a stable environment. On the other hand, part of the phenotypic variation caused by SGE might become advantageous if individuals at the adaptive optimum become genetically less-adaptive, for example due to an environmental change. Furthermore, SGE of unimportant genes might have little or no fitness consequences. Thus, SGE can be advantageous, disadvantageous, or selectively neutral depending on its context. In addition, there might be a genetic basis that regulates magnitude of SGE, which is often referred to as “modifier genes,” but little is known about the conditions under which such an SGE-modifier gene evolves. In the present study, we conducted individual-based computer simulations to examine these conditions in a diploid model. In the simulations, we considered a single locus that determines organismal fitness for simplicity, and that SGE on the locus creates fitness variation in a stochastic manner. We also considered another locus that modifies the magnitude of SGE. Our results suggested that SGE was always deleterious in stable environments and increased the fixation probability of deleterious mutations in this model. Even under frequently changing environmental conditions, only very strong natural selection made SGE adaptive. These results suggest that the evolution of SGE-modifier genes requires strict balance among the strength of natural selection, magnitude of SGE, and frequency of environmental changes. However, the degree of dominance affected the condition under which SGE become sadvantageous, indicating a better opportunity for the evolution of SGE in different genetic models