Additional file 4: Figure S2. of Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene

Cell cycle analysis. Flow cytometric analysis of PI-stained AML cell lines negative to CBFA2T3-GLIS2 fusion gene after 48 h of treatment with GANT61. NT: sample treated with vehicle alone (DMSO). (TIF 183 kb

Additional file 6: Figure S4. of Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene

Cytotoxic effect of either GANT61, or MK-0457 or of GANT61 in association with MK-0457 on A) M07e and in B) WSU-AML cell lines. (TIF 369 kb

Additional file 3: Table S1. of Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene

Genetic features of control AML cell lines. * Data provided by DSMZ and by literature. (XLSX 11 kb

Additional file 5: Figure S3. of Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene

Western blotting analysis of GLI1/2 protein in cell lines either positive or negative for GLIS2 fusion gene treated with GANT61. NT, untreated cells. One representative of three independent experiments is shown. (TIF 205 kb

Additional file 1: of Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene

Materials and methods. (DOCX 22 kb