An observational study of effect on quality of life in perimenopausal females suffering from urinary incontinence

Background: Urinary incontinence (UI) affects many older adults. Some of its deleterious consequences include stress, major depression, diminished quality of life, sexual dysfunction, and familial discord. Despite a wealth of research contributions on this topic, the available literature is under representative of ethnic minority older women.Methods: A cross-sectional observational study was conducted by taking a group of 225 females of perimenopausal age group. Patients were assessed clinically for the diagnosis of urinary incontinence and effect on quality of life was assessed. Further testing was done depending on the storage symptoms & voiding symptoms and included residual volume assessment by ultrasound, cystometry, complex urodynamic test and cystoscopy. The data obtained and the socio-demographic data recorded in a structured proforma. The data obtained was assessed, analysed and results were drawn thereafter.Results: In our study the prevalence of UI was found to be 18%. Maximum prevalence was seen in the age group of 61-70 years. Highest numbers were found to have stress incontinence 60.44%, followed by 23.55% of urge, overflow 5.33% and 10.66% mixed symptoms. The impact was equitable over all dimensions measured for QOL, namely activity limitation (28.44%), social interaction limitation (35.11%), sexual activity limitation (16%), financial burden increased (3.55%), emotional upset and distress (16.88%).Conclusions: In the present study, we determined the prevalence of UI among 200 community-dwelling, ethnically diverse older women, discovered that our new UI screener is reliable, and did not find the UI-depression link to be significant

Influence of protein deficiency on 19S antibody-forming cells in rats and mice

Influence of protein deficiency on immune response to sheep red blood cells was investigated in rats and mice with Jerne's plaque-forming cell technique. Protein deficiency resulted in a reduction in the number of antibody-producing cells consequent upon a prolongation of cell generation time in rats. Injection of syngeneic thymocytes brings about better improvement in the immune response of the X-radiated protein-deficient mice as compared to the controls. It is suggested that depressed immunity in malnutrition may be partly due to a disturbance in thymic function

Inter-state cross border superspreading event of SARS-CoV2 in Central India, May 2020

Background: During the mid-weeks of May 2020, a superspreading event occurred in a town of Central India, where breaking bread together led to an outburst of COVID-19 cases. This led to a sudden increase of the daily average number of cases later on in the month.Methods: An epidemiological investigation was done to investigate the cause. Process of the epidemic investigation done has been described under three parts namely - Case finding, Contact tracing, Public health response.Results: Our epidemiological investigation and contact tracing of the index case confirmed a superspreading event of COVID-19 which occurred due to multiple social gatherings during mid weeks of May 2020. It was estimated that 118 cases belonged to G0 and 94 cases belonged to G1 generation of the index case.Conclusions: Most likely source of infection to the index case was from the guests who came for a social gathering on May 11, 2020 (lockdown 3) from a village across the border in Rajasthan, a high COVID-19 prevalent zone (Orange) to a low COVID-19 prevalent zone (Green)

Population-based incidence of intussusception and a case-control study to examine the association of intussusception with natural rotavirus infection among Indian children

Background: A rotavirus vaccine previously licensed in the United States was withdrawn because it caused intussusception. Data on background intussusception rates in developing countries are required to plan pre- and postlicensure safety studies for new rotavirus vaccines. Also, it is unclear whether natural rotavirus infection is associated with intussusception. Methods: Passive surveillance for intussusception in a large, well-defined, poor, urban population in Delhi, India, was conducted in 2 phases. Intussusception was confirmed by ultrasonography or surgery. Fecal samples obtained from patients with intussusception at study hospitals (irrespective of their residence in study areas) and healthy control subjects were tested for rotavirus with use of enzyme immunoassay. If available, resected intestinal tissue samples were tested for rotavirus with use of immunohistochemistical analysis and reverse-transcription polymerase chain reaction. Results: The incidence of intussusception requiring hospitalization was 17.7 cases per 100,000 infant-years of follow-up (95% confidence interval, 5.9-41.4 cases per 100,000 infant-years). Detection rates of rotavirus in stool samples did not differ significantly between case patients and control subjects (4 of 42 case patients vs 6 of 92 control subjects), and no evidence of rotavirus was detected in any of the 22 patients with intussusception for whom intestinal tissue samples were available. Conclusions: The incidence of intussusception among Indian infants appears to be lower than that reported in other middle- and high-income countries. Natural rotavirus infection does not appear to be a major cause of intussusception in Indian infants

An observational study of effect on quality of life in perimenopausal females suffering from urinary incontinence

Background: Urinary incontinence (UI) affects many older adults. Some of its deleterious consequences include stress, major depression, diminished quality of life, sexual dysfunction, and familial discord. Despite a wealth of research contributions on this topic, the available literature is under representative of ethnic minority older women.Methods: A cross-sectional observational study was conducted by taking a group of 225 females of perimenopausal age group. Patients were assessed clinically for the diagnosis of urinary incontinence and effect on quality of life was assessed. Further testing was done depending on the storage symptoms & voiding symptoms and included residual volume assessment by ultrasound, cystometry, complex urodynamic test and cystoscopy. The data obtained and the socio-demographic data recorded in a structured proforma. The data obtained was assessed, analysed and results were drawn thereafter.Results: In our study the prevalence of UI was found to be 18%. Maximum prevalence was seen in the age group of 61-70 years. Highest numbers were found to have stress incontinence 60.44%, followed by 23.55% of urge, overflow 5.33% and 10.66% mixed symptoms. The impact was equitable over all dimensions measured for QOL, namely activity limitation (28.44%), social interaction limitation (35.11%), sexual activity limitation (16%), financial burden increased (3.55%), emotional upset and distress (16.88%).Conclusions: In the present study, we determined the prevalence of UI among 200 community-dwelling, ethnically diverse older women, discovered that our new UI screener is reliable, and did not find the UI-depression link to be significant

Cell regeneration in protein deficiency

Lesions of organs with a high protein turnover are characteristic of kwashiorkor in humans. These lesions have been reproduced in rhesus monkeys by feeding them protein deficient diets. On the basis of a study of the cell population kinetics of the mucosa of the small intestine in this primate, it has been suggested that a retardation of cellular proliferation is characteristic of protein deficiency. In this communication, we describe preliminary observations on the influence of protein deficiency on cell population kinetics in regenerating livers of rats after partial hepatectomy

Enhancement of aflatoxin B<SUB>1</SUB>-induced hepatocarcinogenesis in rats by partial hepatectomy

The effect of enhanced cell replication induced by partial hepatectomy (PH) in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis has been studied in rats of the inbred As2 strain. Animals were given 0.25 mg/kg body weight of AFB1 as a single intraperitoneal dose 24 h after PH. Nonhepatectomized animals given the same dose of AFB1 served as controls. Neoplastic nodules and hepatocellular carcinoma (HCC) were detected respectively in 100% and 90% of hepatectomized animals sacrificed between 55 and 65 weeks after AFB1 administration. None of the ten non-hepatectomized rats sacrificed at this time interval showed HCC or neoplastic nodules. On histochemical staining the tumour population was found to be heterogeneous. Thus PH resulted in enhancement of AFB1-induced hepatocarcinogenesis in rats of the AS2 strain

The effect of different root canal sealers on the fracture resistance of endodontically treated teeth-in vitro study

Background: The aim of this study was to compare the in vitro effects of four different root canal sealers on the fracture resistance of endodontically treated teeth. Materials and Methods: Seventy-five freshly extracted human mandibular premolars were used for the study. Teeth were divided into five groups based on type of root canal sealers used. Gutta-percha was used for all the samples: Group I: AH Plus root canal sealer, Group II: MTA Fillapex root canal sealer, Group III: Apexit root canal sealer, Group IV: Conventional zinc oxide-eugenol (ZOE) sealer, Group V: Control (unobturated teeth). The teeth were embedded in acrylic resin blocks and fracture force was measured using a universal testing machine (Asian Test Equipments). Data obtained were statistically evaluated using one-way ANOVA and post hoc test (Tukey's test). All groups showed statistically significant result (P < 0.05). Results: Group I and Group II showed higher resistance to fracture than other three groups. There was comparable difference in fracture force between Group I and Group II. Moreover, there was no statistically significant difference between Group III and Group IV and between Group IV and Group V. Conclusion: Based on this in vitro study, resin-based sealer was more effective as compared to other sealers and the control group. However, no significant differences were observed between ZOE and control group

Effect of Low-level LASER Therapy on P6 Acupoint to Control Gag Reflex in Children: A Clinical Trial

Objective: To investigate the effect of low level laser therapy (LLLT) on PC6 acupuncture point in suppressing gag reflex, regulating pulse rates and oxygen saturation, thereby reducing the anxiety levels. Materials and Method: A total of 40 patients who demonstrated hyperactive gag reflex in the age group of 4-14 years were included in the study. In Group A (20 patients), maxillary impression was recorded. In the second step, PC6 acupuncture point was stimulated with LLLT followed by recording of second maxillary impression. In group B (20 patients), steps were reversed. Gag reflex, anxiety levels, pulse rate and oxygen saturation levels were assessed. Results: Values of pulse rate and oxygen saturation were regulated to normal, signifying lowered anxiety levels. Gag reflex was also significantly decreased after stimulating PC6 acupuncture point with LLLT. Conclusion: LLLT on PC6 point was found to be effective in lowering anxiety levels as observed by faces modified anxiety rating scale. Further, it was authenticated as the pulse rates were significantly reduced and oxygen saturation levels were significantly increased. Also, gag reflex was significantly controlled when LASER stimulation was done at PC6