Quantitative structure-activity relationship studies on antituberculotic N₁- cyclopropylquinolones using Szeged Index (Sz)

1203-1208A novel application of Szeged index (Sz) for modeling antituberculotic activities  of N1- cyclopropylquinolones is described. The correlation  potential of Sz has been compared with correlation ability of the molecular orbital energies: energy of highest occupied molecular orbital (<i style="mso-bidi-font-style: normal">EH), energy of lowest unoccupied molecular orbital (EL) and total π-electron energy (ET). Mono-parametric regression analysis has indicated that Sz and ET are the appropriate parameters for quantitative structure-activity relationship (QSAR). The results are highly improved by the introduction of an indicator parameter using multiple correlation analysis. </span

Sporting and physical activity following hip resurfacing

The aim of this study was to assess sporting and physical activities in patients who had undergone hip resurfacing. Our study included 117 patients who underwent hip resurfacing between 2003 and 2008. University of California at Los Angeles (UCLA) activity level and Oxford hip scores (OHS) were used. Sporting and physical activities of all patients were analysed pre- and postoperatively. The mean age at surgery was 54 years. The mean follow up was 30 months. There was statistically significant improvement in UCLA activity scores from 4.4 to 6.8 (p < 0.05) and Oxford hip scores from 43.4 to 17.7 following surgery. Eighty-seven percent of patients continued to take part in sporting activities following hip resurfacing. Our study has demonstrated that hip resurfacing can allow patients to remain extremely active