Potentiel d’indication chirurgicale de l’epilepsie en milieu neuropsychiatrique a Kinshasa: cas du centre de sante mentale telema etude preliminaire

Contexte et objectifs Environ 30% des patients épileptiques ne répondent pas au traitement médical et deviennent des candidats potentiels pour un traitement chirurgical dont l’indication repose sur les données électro-cliniques et d’imagerie. L’objectif de cette étude était de décrire les caractéristiques anthropométriques et cliniques ainsi que l’évolution sous traitement des patients épileptiques, de documenter le niveau d’investigation de cette pathologie afin d’identifier les patients potentiellement éligibles pour un traitement chirurgical.Méthodologie Il s’agit d’une étude documentaire descriptive couvrant une période de 2 ans. Les variables d’intérêt comprenaient : les données anthropométriques, les caractéristiques de l’épilepsie, les données thérapeutiques, le niveau et les résultats des investigations complémentaires.Résultats Au total, 1184 dossiers de nouveaux cas d’épilepsie ont été retenus. L’âge médian était de 19 ans avec un sex ratio H/F de 1,1. 68% des patients avaient un âge de début inférieur à 20 ans et plus de 90% avaient des crises généralisées tonico-cloniques. La disparition des crises sous traitement était observée chez 31% des patients et 22% avaient une persistance ou une aggravation. L’EEG était réalisé chez 17% des patients et le scanner cérébral chez 0,8%. Vingt (20 )% des patients avaient reçu au moins 2 antiépileptiques. Environ 26 % des patients suivis pendant 2 ans ou plus étaient considérés réfractaires.Conclusion L’épilepsie affecte les patients en âge scolaire et les jeunes adultes qui sont des candidats de choix pour la chirurgie en cas de pharmaco-résistance. La pathologie reste cependant très peu investiguée. Un programme d’investigation plus large permettra d’identifier notamment les épilepsies lésionnelles afin de soumettre ces patients à une évaluation en vue d’un traitement neurochirurgical.Mots clés : Afrique sub-saharienne - Chirurgie de l’épilepsie - Epilepsie réfractaire -Evaluation préchirurgicale - Imagerie par Résonance Magnétique

Discontinuation and switching of postpartum contraceptive methods over twelve months in Burkina Faso and the Democratic Republic of the Congo: a secondary analysis of the Yam Daabo trial.

IntroductionWomen who use contraceptive methods sometimes stop early, use methods intermittently, or switched contraceptive methods. All these events (discontinuations and switching) contribute to the occurrence of unwanted and close pregnancies. This study aimed to explore contraceptive discontinuation and switching during the Yam-Daabo project to measure the effect of interventions on the continuation of contraceptive methods use.MethodsWe conducted a secondary analysis of the Yam-Daabo trial data. We choose the discontinuation and switching of a modern contraceptive method as outcome measures. We performed a survival analysis using the Stata software package to estimate the effect of the interventions on contraceptive discontinuation. We also studied the main reasons for discontinuation and switching.ResultsIn total, 637 out of the 1120 women used at least one contraceptive method (of any type), with 267 women in the control and 370 in the intervention group. One hundred seventy-nine women of the control group used modern methods compared to 279 women of the intervention group with 24 and 32 who discontinued, respectively. We observed no statistically significant association between interventions and modern methods discontinuation and switching. However, modern methods' discontinuation was higher in pills and injectables users than implants and IUDs users. The pooled data comparison showed that, in reference to the women who had not switched while using a modern method, the likelihood of switching to a less or equal effectiveness method among the women of the control group was 3.8(95% CI: 1.8-8.0) times the likelihood of switching to a less or equal effectiveness method among the women of the intervention group. And this excess was statistically significant (p ConclusionThe results of this study show no statistically significant association between interventions and modern methods discontinuation. Discontinuation is more related to the methods themselves than to any other factor. It is also essential to set up specific actions targeting women's partners and influential people in the community to counter inhibiting beliefs.Trial registrationPan African Clinical Trials Registry (PACTR201609001784334, https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=1784 )

Effectiveness of post-partum family planning interventions on contraceptive use and method mix at 1 year after childbirth in Kinshasa, DR Congo (Yam Daabo): a single-blind, cluster-randomised controlled trial.

BACKGROUND:In rural Burkina Faso, a package of six low-technology, post-partum contraceptive interventions (ie, refresher training for providers, a counselling tool, supportive supervision, daily availability of contraceptive services, client appointment cards, and invitation letters to attend appointments for partners), aimed at strengthening existing primary health-care services and enhancing demand for them, doubled the use of modern contraceptives at 12 months post partum (ie, 55% uptake in intervention recipients vs 29% in routine-care users). This study assessed the effect of a similar package but in urban settings of Kinshasa province, Democratic Republic of the Congo, in an effort to reduce the unmet need for post-partum family planning. METHODS:Yam Daabo was a multi-intervention, single-blinded, cluster-randomised controlled trial done in six primary health-care centres (clusters) in Kinshasa. Centres were randomly allocated to receive the six-component intervention or standard antenatal and postnatal care in matched pairs (1:1) on the basis of number of monthly births, the ratio of health workers per population in the health zone, and the urban and suburban settings. Only data analysts could be masked to cluster allocation. Health-care facilities were eligible if they provided a continuum of antenatal, delivery, and postnatal care, were well stocked with contraceptives, and were situated close to the main study centre. All pregnant women presenting to the six centres were eligible if they were in their third pregnancy trimester and had no counterindications to deliver in the facility. The main outcome was prevalence of use of modern contraceptives at 12 months after delivery. Analysis was by modified intention-to-treat using generalised linear mixed models or Fisher's exact test for small groups. Prevalence ratios were adjusted for cluster effects and baseline characteristics. This study was registered with the Pan-African Clinical Trials Registry (PACTR201609001784334). FINDINGS:From July 1, 2016, to Feb 2, 2017, eight of 52 clinics assessed for eligibility met the criteria and were randomised. Of 690 women approached, 576 (83%) women were enrolled: 286 in the four intervention clusters and 290 in the four control clusters. Of them, 519 (90%) completed the 12-month study exit interview (252 in the intervention group and 267 in the control group) and were included in the intention-to-treat analysis. At 12 months, 115 (46%) of 252 women in the intervention group and 94 (35%) of 267 in the control group were using modern contraceptives (adjusted prevalence ratio [PR] 1·58, 95% CI 0·74-3·38), with significant differences in the use of contraceptive implants (22% vs 6%; adjusted PR 4·36, 95% CI 1·96-9·70), but without difference in the use of short-acting contraceptives (23% vs 28%; 0·92, 0·29-2·98) and non-modern or inappropriate methods (7% vs 18%; 0·45, 0·13-1·54). There were no serious adverse events or maternal deaths related to the study. INTERPRETATION:The Yam Daabo intervention package did not have a significant effect on the overall use of effective modern contraceptives but significantly increased implant use in women post partum who live in urban settings in Kinshasa up to a year after childbirth. However, interferences from external family planning initiatives in the control group might have diminished differences between the services received. Such an intervention could be potentially relevant in similar contexts in DR Congo and other countries. FUNDING:Government of France; UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction

Postpartum family-planning barriers and catalysts in Burkina Faso and the Democratic Republic of Congo: a multiperspective study

Nguyen Toan Tran,1–3,* Wambi Maurice E Yameogo,4,5,* Mary Eluned Gaffield,1 Félicité Langwana,6 James Kiarie,1 Désiré Mashinda Kulimba,6 Seni Kouanda4,5 1Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland; 2Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology, Sydney, NSW, Australia; 3Institute of Demography and Socioeconomics, University of Geneva, Geneva, Switzerland; 4Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso; 5Institut Africain de la Santé Publique, Ouagadougou, Burkina Faso; 6School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo *These authors contributed equally to this work Purpose: To address the high unmet need for postpartum family planning (PPFP) in resource-limited settings, particularly in sub-Saharan Africa, this study aimed to identify PPFP-related barriers and catalysts to inform policies and programs to increase access to postpartum contraception.Methods: Using qualitative methodology, we explored the perspectives of women, adolescent girls, men, religious and community leaders, service providers, and decision makers from three rural communities in Burkina Faso and three rural–urban communities in the Democratic Republic of Congo. Both countries have high unmet need for PPFP and are priority countries of the French Muskoka Fund for Maternal and Child Health.Results: Perceived catalysts included negative traditional views on the consequences borne by closely spaced children and their mothers; a 6-week postpartum visit dedicated to PPFP (albeit poorly attended); political will and enabling policies for FP; and support from certain religious leaders and men. Main reported barriers were the lack of male engagement; out-of-pocket copayment for contraceptives; reliance on amenorrhea for pregnancy prevention without knowing its limits; misconceptions about modern contraceptives, including prerequisites for the lactational amenorrhea method; sexual abstinence supported by religious and traditional norms for up to 3–6 months, although women reported earlier resumption of sexual activity; low prioritization of scheduled postpartum visits by women; and limited availability of readily accessible methods, PPFP counseling materials, and clinic days and scheduled visits dedicated to contraceptive services.Conclusion: Based on results found to be most actionable, the following interventions have the potential to optimize access to PPFP services: counseling women on postpartum-pregnancy risks and options at different points in time before and after childbirth through the use of appropriate information, education, and counseling materials; integrating PPFP services into existing maternal and child health visits; making contraceptives readily available and affordable; and meaningfully engaging male partners. Keywords: postpartum contraception, barriers, enablers, sub-Saharan Africa, Burkina Faso, Democratic Republic of Cong