Bone graft on the labial symphysis for the skeletal Class III case

通常臨床歯科医学における骨移植は,その病理学的形態より3壁性骨欠損を有する歯周病患者に対して広く行われている。今回,下顎前歯部(下顎結合部)唇側面歯槽骨の開窓や限局性穿孔は存在するが,歯肉退縮を生じていない骨格型III級不正咬合患者へ顎矯正手術と同時に自家骨移植を付加的に行った。初診時のセファログラム所見より高く幅の狭い下顎結合部とこの薄い骨に直立している下顎前歯が確認された。また,術前矯正歯科治療中,下顎前歯はその捻転の解消と頬舌的な移動が行われた。手術時には下顎前歯部の開窓や限局性穿孔が確認された。下顎前歯部(下顎結合部)唇側面に自己海面骨を移植することによって歯槽骨の開窓や限局性穿孔は覆われた。結果的にセファログラム上での経過所見より,その後4年10か月間移植骨の残留が認められ,さらに臨床的に咬合が安定し通常後戻りしやすいとされる下顎前歯捻転の後戻りも認められず良好な結果を得たので報告した。Bone graft in clinical dentistry prevails in periodontal patients who have three wall infrabony defect around the tooth because of its pathological morphology. In this case report, bone graft on the labial bone surface of the lower incisors (mandibular symphysis) was applied as an auxiliary procedure at the same time of orthognathic surgery to a patient who had fenestrations and circumscribed holes without gingival recession and skeletal Class III malocclusion. The initial lateral cephalometric radiograph revealed a narrow and high symphysis, with an incisor position straight above the thin bone. During the pre-surgical orthodontic treatment, the incisors had been derotated and moved in the minimal labiolingual direction. Some fenestrations and circumscribed holes were found during orthognathic surgery. Through the bone allograft, the labial bone surface of the lower incisors (mandibular symphysis) with fenestrations and circumscribed holes were covered with the patient\u27s cancellous bone. Consequently, a series of the lateral cephalometric radiographs revealed that the grafted bone was kept for four years and ten months after surgery with stable occlusion and no rotational relapse on the lower incisors where it is usually easy to relapse clinically

A Protective Role by Interleukin-17F in Colon Tumorigenesis

Interleukin-17F (IL-17F), produced by Th17 cells and other immune cells, is a member of IL-17 cytokine family with highest homology to IL-17A. IL-17F has been shown to have multiple functions in inflammatory responses. While IL-17A plays important roles in cancer development, the function of IL-17F in tumorigenesis has not yet been elucidated. In the current study, we found that IL-17F is expressed in normal human colonic epithelial cells, but this expression is greatly decreased in colon cancer tissues. To examine the roles of IL-17F in colon cancer, we have used IL-17F over-expressing colon cancer cell lines and IL-17F-deficient mice. Our data showed decreased tumor growth of IL-17F-transfected HCT116 cells comparing to mock transfectants when transplanted in nude mice. Conversely, there were increased colonic tumor numbers and tumor areas in Il-17f−/− mice than those from wild-type controls after colon cancer induction. These results indicate that IL-17F plays an inhibitory role in colon tumorigenesis in vivo. In IL-17F over-expressing tumors, there was no significant change in leukocyte infiltration; instead, we found decreased VEGF levels and CD31+ cells. While the VEGF levels were increased in the colon tissues of Il-17f−/− mice with colon cancer. Together, our findings demonstrate a protective role for IL-17F in colon cancer development, possibly via inhibiting tumor angiogenesis