Impact of aging on the auditory system and related cognitive functions: A narrative review

Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world’s population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia. Here we review the current evidence for the age-related changes of the peripheral and central auditory system and the relationship between hearing loss and pathological cognitive decline and dementia. Furthermore, there is a paucity of evidence on the relationship between ARHL and established biomarkers of Alzheimer’s disease, as the most common cause of dementia. Such studies are critical to be able to consider any causal relationship between dementia and ARHL. While this narrative review will examine the pathophysiological alterations in both the peripheral and central auditory system and its clinical implications, the question remains unanswered whether hearing loss causes cognitive impairment or vice versa

Major Cost Drivers in Assessing the Economic Burden of Alzheimer’s Disease:A Structured, Rapid Review

Background: Alzheimer’s Disease is the most common cause of dementia, affecting memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks. AD is predicted to increase healthcare spending and costs associated with formal and informal caregiving. The aim of this study was to identify and quantify the contribution of the different cost components associated with AD. Methods: A structured literature review was conducted to identify studies reporting the economic burden of Alzheimer`s Disease beyond the healthcare setting. The search was conducted in Medline, Embase and EconLit and limited to studies published in the last 10 years. For each identified cost component, frequency weighted mean costs were calculated across countries to estimate the percentage contribution of each component by care setting and disease severity. Results obtained by each costing approach were also compared. Results: For community-dwelling adults, the percentage of healthcare, social care and indirect costs to total costs were 13.9%, 17.4% and 68.7%, respectively. The percentage of costs varied by disease severity with 26.0% and 10.4% of costs spent on healthcare for mild and severe disease, respectively. The proportion of total spending on indirect costs changed from 60.7% to 72.5% as disease progressed. For those in residential care, the contribution of each cost component was similar between moderate and severe disease. Social care accounted on average for 85.9% of total costs. Conclusion: The contribution of healthcare costs to the overall burden was not negligible; but was generally exceeded by social and informal care costs

Physiological responses of Lupinus luteus to different copper concentrations

Yellow lupin (Lupinus luteus L.) plants were grown in hydroponic solution for 15 d under different copper concentrations (0.1, 0.5, 1.0, 10, 25 and 50 μM). With increasing Cu concentration total biomass was not affected, leaf area slightly decreased, while chlorophyll content decreased considerably. Cu content increased significantly both in roots and in leaves, but the contents of other ions were only slightly affected at the highest Cu concentration (Mn content decreased both in roots and in leaves, P content decreased only in leaves and Zn content increased in roots). Superoxide dismutase (SOD) activity increased up to day 7 after copper application. Peroxidase (GPOD) and polyphenol oxidase (PPO) activities also increased, while catalase (CAT) activity remained constan

A wide array of lignin-related phenolics are oxidized by an evolved bacterial dye-decolourising peroxidase

Lignin is the second most abundant natural polymer next to cellulose and by far the largest renewable source of aromatic compounds on the planet. Dye-decolourising peroxidases (DyPs) are biocatalysts with immense potential in lignocellulose biorefineries to valorize emerging lignin building blocks for environmentally friendly chemicals and materials. This work investigates the catalytic potential of the engineered PpDyP variant 6E10 for the oxidation of 24 syringyl, guaiacyl and hydroxybenzene lignin-phenolic derivatives. Variant 6E10 exhibited up to 100-fold higher oxidation rates at pH 8 for all the tested phenolic substrates compared to the wild-type enzyme and other acidic DyPs described in the literature. The main products of reactions were dimeric isomers with molecular weights of (2 × MWsubstrate - 2 H). Their structure depends on the substitution pattern of the aromatic ring of substrates, i.e., of the coupling possibilities of the primarily formed radicals upon enzymatic oxidation. Among the dimers identified were syringaresinol, divanillin and diapocynin, important sources of structural scaffolds exploitable in medicinal chemistry, food additives and polymers.info:eu-repo/semantics/publishedVersio

Staircases of wave-cut platforms in western central Portugal (Cape Mondego to Cape Espichel) – relevance as indicators of crustal uplift Escadarias de terraços marinhos em Portugal centro-ocidental (Cabo Mondego ao Cabo Espichel) – relevância como indicadores de soerguimento crustal

This study addresses coastal terrace staircases of western central Portugal (Cape Mondego to Cape Espichel). Below the culminant marine unit, that records the last episode of aggradation before the ongoing stage of incision, several terrace levels are identified. The following methodology was used: a) production of geomorphological maps, combining analysis of detailed MDT’s and aerial photos, with field surveys calibrated with GPS data; b) stratigraphic and sedimentological study of the sedimentary deposits associated with the marine platforms; c) luminescence dating. On each terrace staircase, the number of platforms and their elevations are different, indicating differential uplift. Quartz OSL provided age estimates up ca. 150 kyr and post-IR IRSL on K-feldspar up to ca. 700 kyr for the marine terraces under study. Using the culminant platform as reference and assuming that it is 3.6 Ma old, uplift rates were estimated as ranging from 0.071 m/ky to 0.019 m/ky. The ongoing luminescence dating will provide the uplift rates estimated for the lower and middle marine terrace

ESCADARIAS DE TERRAÇOS MARINHOS EM PORTUGAL CENTROOCIDENTAL – RELEVÂNCIA COMO INDICADORES DE SOERGUIMENTO CRUSTAL STAIRCASES OF WAVE-CUT PLATFORMS IN WESTERN CENTRAL PORTUGAL – RELEVANCE AS INDICATORS OF CRUSTAL UPLIFT

This study addresses the coastal terrace staircases of western central Portugal (Cape Mondego to Cape Espichel). Below the culminant marine unit that records the last episode of aggradation before the ongoing stage of incision, several terrace levels ar identified. The following methodology was used: a) production of geomorphological maps, combining analysis of detailed MDT’s and aerial photos, with field surveys calibrated with GPS; b) stratigraphic and sedimentological study of the sedimentary deposits associated with the marine platforms; c) luminescence dating. On each terrace staircase, the number of platforms and their elevations are different, indicating differential uplift. Quartz OSL provided age estimates up ca. 150 kyr and post-IR IRSL on K-feldspar up to ca. 700 kyr for the marine terraces under study. Using the culminant platform as reference and assuming that it is ca. 3.6 Ma old, uplift rates were estimated as ranging spatially from 0.071 m/ky to 0.019 m/ky. The ongoing luminescence dating will provide uplift rates estimated for the lower and middle marineterraces, clarifying if an acceleration of the crustal uplift is going on

Auditory electrophysiological assessments of Alzheimer\u27s disease and preclinical stages: Protocol for a systematic review and meta-analysis

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Investigating auditory functions in populations at risk of developing Alzheimer\u27s disease (AD) using auditory neurophysiological measurements can potentially identify a crucial and sensitive diagnostic window of opportunity in preclinical AD. Auditory electrophysiological assessments have gained interest as possible tools for early diagnosis of AD. This paper outlines the protocol that will be used to systematically review the published literature currently available on auditory electrophysiological assessments that have been used to assess the auditory functions of adults over the age of 60 years diagnosed with AD or its preclinical stages. Methods and analysis All full-length peer-reviewed publications of original data that use auditory electrophysiological assessments in AD and its preclinical stages (subjective cognitive decline (SCD) and mild cognitive impairment (MCI)) will be considered in this review. The search will be performed on major electronic databases (Ovid MEDLINE, Ovid Embase, PsycINFO, PubMed, Scopus and CINAHL Plus) using keywords alone or in combination with Medical Subject Headings divided into two domains; (i) auditory tests and (ii) AD. The database search will be conducted on the 7 th of May 2019. Data analysis will be completed and reported in the full review. A random effects meta-analysis will also be conducted using the Comprehensive Meta-Analysis software, V.3. This review will describe which auditory electrophysiological tests have been found to be useful in assessing the auditory function in cognitively impaired adults (MCI and AD) or adults with serious complaints about their cognition (SCD). This review will also identify and describe which auditory electrophysiological test demonstrates the most sensitivity in differentiating people at different stages of cognitive decline. Ethics and dissemination This systematic review focusses on analysing already available literature. Therefore, there will be no requirement for ethical approval. The systematic review findings will be disseminated through peer-reviewed publication as well as relevant media platforms, for example, conferences. Systematic review registration PROSPERO CRD42019133553

Clinicopathological and toxicological aspects of poisoning by the clomazone herbicide in sheep

AbstractClomazone (2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone) is a herbicide which has been widely used in southern Brazil in the rice cultivation and can be toxic for humans and animals. This study reports the first outbreak poisoning due to clomazone in a flock of 103 sheep, 20 of which showed mainly neurological and respiratory signs. Clomazone was detected in soil and vegetation samples and in the liver, kidney and muscles of poisoned animals. The poisoning was experimentally reproduced in three sheep by the administration of a 134mgkg body weight dose of clomazone. In both the natural and experimental cases, the clinical signs included tachypnea, anorexia, somnolence, weakness and ataxia. Macroscopically, there were no significant changes. Histologically, vacuolization in the white matter, perineuronal vacuoles and congestion of the leptomeningeal and brain vessels were observed. Ultrastructurally, the vacuolar lesions in the brain corresponded to swelling of the dendrites and astrocytic processes. It is concluded that clomazone causes toxic neuropathy in sheep

Topological defects: A problem for cyclic universes?

We study the behaviour of cosmic string networks in contracting universes, and discuss some of their possible consequences. We note that there is a fundamental time asymmetry between defect network evolution for an expanding universe and a contracting universe. A string network with negligible loop production and small-scale structure will asymptotically behave during the collapse phase as a radiation fluid. In realistic networks these two effects are important, making this solution only approximate. We derive new scaling solutions describing this effect, and test them against high-resolution numerical simulations. A string network in a contracting universe, together with the gravitational radiation background it has generated, can significantly affect the dynamics of the universe both locally and globally. The network can be an important source of radiation, entropy and inhomogeneity. We discuss the possible implications of these findings for bouncing and cyclic cosmological models.Comment: 11 RevTeX 4 pages, 6 figures; version to appear in Phys. Rev.

Project Proof: Internet Enabled Process Reengineering at J.D. Edwards & Company

J.D. Edwards is a provider of the new generation of ERP and collaborative commerce solutions. This case study describes the challenges faced internally by the company to upgrade to the latest enterprise software it would sell to the world. Dubbed Project PROOF, the project started in June 2001 and was completed in November 2002. The perspectives of the CIO, the program manager, and other key personnel are presented. The case study highlights the issues that arise in an enterprise software implementation project. In addition, the case touches upon issues of project management, process redesign, and marketing. The case study uses a multimedia format to add richness and detail. Although J.D. Edwards was acquired in 2003, the issues discussed are relevant to current business practices