Additional file 1 of Synergistic lethality in chronic myeloid leukemia – targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment

Additional file 1: Supplementary Table 1. Inhibitor concentrations. Supplementary Table 2. Antibodies and reagents for flow cytometry. Supplementary Table 3. Primer for quantitative real‐time PCR. Supplementary Table 4. Antibodies for western blot. Supplementary Figure 1. Gating strategy for FACS analyses. Supplementary Figure 2. TKIs affect CML cell metabolism. Supplementary Figure 3. Unpooled data of Figure 1b,c. Supplementary Figure 4. Imatinib has no significant effect on oxPhos complex expression. Supplementary Figure 5. Thapsigargin increases the lethality of CML cells in combination with TKIs. Supplementary Figure 6. Oligomycin induces ER stress and imatinib blocks ATF4 upregulation (uncropped images of Figure 3a). Supplementary Figure 7. Oligomycin and thapsigargin induce cleavage of caspase 3 in combination with imatinib in the cell lines K562 and KU812 (uncropped images of Figure 4a)