Edible films based on black chia (Salvia hispanica l.) seed mucilage containing Rhus microphylla fruit phenolic extract

Functional films based on black chia (Salvia hispanica L.) seed mucilage (BCm) containing Rhus microphylla (Rm) fruit phenolic extract were built and characterized. A hydro-alcohol extract (HAE) of Rm was incorporated as the bioactive agent due to its noteworthy phenolic profile, and good antioxidant and antifungal activities. The effects of the BCm concentration (0.2% and 0.4%, w/v), HAE incorporation, and their interaction with glycerol (1.0%, w/v) and calcium chloride (0.05%, w/v) on the films physicochemical properties were evaluated. The filmogenic solutions successfully fitted to the HerschelBulkley model (R2 0.05) changed by the HAE addition, but their surface tension was enhanced (p < 0.05), which could favor their coating ability. The polyanionic nature of the systems (zeta potential-Zp values from 26.9 to 33.3 mV) allowed them to interact with Ca2+ cations, thus forming stable and resistant films. All the films showed low water solubility (15.0% to 22.3%) and high permeability (3.7 to 4.0 × 1010 g m1 s1 Pa1), as well as high biodegradability (moisture content from 66.0% to 80.9%); although the moisture content was reduced (p < 0.05) with HAE addition. The combination of higher BCm ratio and HAE addition (BCm0.4+Rm) led to a more resistant, thick, opaque, and dark film compared with the others obtained. This study reveals the BCm-based films potential, highlighting those with HAE, representing a novel alternative to improve the quality of food products.Financial support from Universidad Autónoma Agraria Antonio Narro (UAAAN) is gratefully acknowledged by the authors. Zlatina Genisheva thanks to Foundation for Science and Technology (FCT) for the financial support (ref. SFRH/BPD/108868/2015) and to the project COMPETE 2020 (POCI-01-0145-FEDER-029145). This study was supported by FCT under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. The authors would also like to thank to Pablo Virgen of Biocampo S.A. de C.V. and MSc Fidel Peña-Ramos from UAAAN, for their assistance during this study.info:eu-repo/semantics/publishedVersio

Hacia un proceso penal más reparador y resocializador: avances desde la justicia terapéutica

La obra que se presenta al lector trata de dar a conocer la Justicia Terapéutica a los investigadores y profesionales que trabajan en su día a día con personas que se enfrentan a un proceso penal, ya sea como víctima o victimario, para mostrarles una visión distinta de nuestro sistema de justicia penal que pueda ofrecer una respuesta más humana. Para cumplir ese objetivo, se inicia la obra con tres capítulos, que pueden considerarse introductorios, en los que se parte del concepto de Justicia Terapéutica desde sus orígenes en Estados Unidos, con las obras de los Profesores Wexler y Winick, para diferenciarla después de la justicia restaurativa y resaltar la importancia de formar a los operadores jurídicos en Justicia Terapéutica para de esta forma poner a su disposición nuevas herramientas en su quehacer diario que redunden en beneficio de quienes están involucrados en el proceso penal. A partir de aquí y a lo largo de los capítulos siguientes se van analizando las distintas figuras jurídicas propias del proceso penal y los programas de intervención con víctimas o victimarios que encajan con los postulados de la Justicia Terapéutica.Presentación / Esther Pillado González (pp. 11-12). -- Aproximación al concepto de justicia terapéutica / Esther Pillado González (pp. 13-24). -- Justicia restaurativa y justicia terapéutica: hacia una praxis reflexiva de transgresiones disciplinares / Gema Varona Martínez (pp. 25- 55). -- Formación de los operadores jurídicos en justicia terapéutica / Tamara Martínez Soto (pp. 57-90). -- Desistimiento en supuestos de delitos leves y conformidad como manifestaciones de justicia terapéutica / María Dolores Fernández Fustes (pp. 91-124). -- Mediación y justicia terapéutica / Silvia Barona Vilar (pp. 125-168). -- La denominada prisión provisional "atenuada" como manifestación de justicia terapéutica en el Derecho Español / Pablo Grande Seara (pp. 169-201). -- La protección de la víctima del delito desde el punto de vista de la justicia terapéutica / Izaskun Porres García (pp. 203-223). -- Prueba pericial psicológica en víctimas de violencia de género con enfoque de justicia terapéutica / Ramón Arce Fernández, Francisca Fariña Rivera, Mercedes Novo Pérez y Dolores Seijo Martínez (pp. 225-249). -- Evaluación e intervención con víctimas menores de edad desde la perspectiva de la justicia terapéutica. Especial referencia a las víctimas de abuso sexual infantil / Noemí Pereda Beltran y Mila Arch Marín (pp. 251-281). -- La función del juez en la determinación y ejecución de las sanciones penales privativas de libertad / Ignacio José Subijana Zunzunegui (pp. 283-311). -- A propósito de la suspensión ampliada de la pena: algunas notas sobre el acuerdo alcanzado en virtud de mediación / Fernando Vázquez-Portomeñe Seijas (pp. 313-338). -- La regulación de la libertad condicional para internos primarios: una lectura desde la justicia terapéutica / Natalia Pérez Rivas (pp. 339-372). -- Aplicación de la justicia terapeútica en la intervención con hombres que han ejercido violencia de género / Francisca Fariña Rivera, Mercedes Novo Pérez, Dolores Seijo Martínez y Ramón Arce Fernández (pp. 373-396). -- Intervención en agresores sexuales: aportaciones de la justicia terapéutica / Rui Abruhnosa Gonçalves (pp. 397-404). -- Próximos pasos en el desarrollo de la justicia terapéutica / David B. Wexler y Karla G. González Vázquez (pp. 405-412)

Los desafíos del cambio : investigación en diseño

1 archivo PDF (194 páginas)Aborda los desafíos del cambio y la investigación en diseño - a 30 años de distancia de la creación de la Universidad Autónoma Metropolitana y de ejercer la figura de profesor investigador, signo distintivo de nuestra Institución -trata los cambios y desafíos que se han presentado durante este tiempo, con relación a su objeto de estudio, la manera como se concibe y realiza la investigación, como en la práctica se ha dado - o no- el binomio investigación docencia y cómo se enfrentan las dificultades y las soluciones que han tomado los profesores-investigadores

HIV and HCV screening by non-infectious diseases physicians: can we improve testing and hidden infection rates?

BackgroundMissed opportunities for Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) testing remain high. We aimed to ascertain the knowledge of screening guidelines and attitudes of non-infectious disease (ID) hospital physicians and assess the impact of a 1-h session on screening rates and diagnoses.MethodsThis interventional study consisted of a 1-h training session on HIV and HCV epidemiology and testing guidelines for non-ID physicians. Pre-and post-session questionnaires compared the knowledge of the guidelines and attitudes toward screening before and after the session. Rates of screening and diagnoses were compared in three 6 months periods: before, immediately after, and 24 months ±4 after the session.ResultsA total of 345 physicians from 31 departments participated in these sessions. Before the session, 19.9% (28% medical, 8% surgical) and 17.9% (30% medical, 2.7% surgical) were aware of HIV and HCV testing guidelines, respectively. The willingness to routinely test increased from 5.6 to 22%, whereas not ordering tests decreased from 34.1 to 2.4%. HIV screening rates significantly increased by 20% after the session (7.7 vs. 9.3 tests per 103 patients; p &lt; 0.001), and the effect persisted until the long-term period. The HIV diagnosis rate increased globally (3.6 vs. 5.2 HIV diagnoses per 105 patients; p = 0.157), mainly because of medical services (4.7 vs. 7.7 per 105 patients; p = 0.082). The HCV screening rate increased significantly immediately and in the long term only in medical services (15.7 and 13.6%, respectively). The new active HCV infection rates increased immediately and declined steeply thereafter.ConclusionA short session for non-ID physicians can improve HIV/HCV screening, increase diagnosis, and contribute to disease elimination

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Clinical guideline for the treatment of dual pathology in the adult population

S

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file

Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk

The aim of this study was to ascertain the association between the consumption of different categories of edible olive oils (virgin olive oils and olive oil) and olive pomace oil and ankle-brachial pressure index (ABI) in participants in the PREDIMED-Plus study, a trial of lifestyle modification for weight and cardiovascular event reduction in individuals with overweight/obesity harboring the metabolic syndrome. Methods: We performed a cross-sectional analysis of the PREDIMED-Plus trial. Consumption of any category of olive oil and olive pomace oil was assessed through a validated food-frequency questionnaire. Multivariable linear regression models were fitted to assess associations between olive oil consumption and ABI. Additionally, ABI ≤1 was considered as the outcome in logistic models with different categories of olive oil and olive pomace oil as exposure. Results: Among 4330 participants, the highest quintile of total olive oil consumption (sum of all categories of olive oil and olive pomace oil) was associated with higher mean values of ABI (beta coefficient: 0.014, 95% confidence interval [CI]: 0.002, 0.027) (p for trend = 0.010). Logistic models comparing the consumption of different categories of olive oils, olive pomace oil and ABI ≤1 values revealed an inverse association between virgin olive oils consumption and the likelihood of a low ABI (odds ratio [OR] 0.73, 95% CI [0.56, 0.97]), while consumption of olive pomace oil was positively associated with a low ABI (OR 1.22 95% CI [1.00, 1.48]). Conclusions: In a Mediterranean population at high cardiovascular risk, total olive oil consumption was associated with a higher mean ABI. These results suggest that olive oil consumption may be beneficial for peripheral artery disease prevention, but longitudinal studies are needed