Asymmetric Synthetic Strategy of Fosfomycin Using Biocatalysis

This presentation was given at Pacifichem

Synthesis of Fosfomycin Using Whole-Cell Biocatalysis as the Key Step

This presentation was given at the Armstrong Student Scholarship Symposium

Synthesis of Fosfomycin Using Whole-Cell Biocatalysis as the Key Step

This presentation was given at the ACS National Meeting

Asymmetric Synthesis of (-)-fosfomycin and its Trans- (1S,2S)-diastereomer Using a Biocatalytic Reduction as the Key Step

Fosfomycin is a gram positive and gram negative antibiotic that contains an asymmetric epoxide. An enzyme library was screened for its ability to reduce dimethyl(1-chloro-2-oxopropyl)phosphonate to the corresponding asymmetric chlorohydrin. Homology models were built in MOE, which were shown to accurately model the enzyme–substrate complex displaying the stereoselectivity that we observed. Two enzymes, YDR368w and YHR104w, were chosen for the scale up and synthesis of fosfomycin and its trans-(1S,2S)-diastereomer

Redder than Red: Discovery of an Exceptionally Red L/T Transition Dwarf

We present the discovery of CWISE J050626.96+073842.4 (CWISE J0506+0738), an L/T transition dwarf with extremely red near-infrared colors discovered through the Backyard Worlds: Planet 9 citizen science project. Photometry from UKIRT and CatWISE give a ( J − K ) _MKO color of 2.97 ± 0.03 mag and a J _MKO − W2 color of 4.93 ± 0.02 mag, making CWISE J0506+0738 the reddest known free-floating L/T dwarf in both colors. We confirm the extremely red nature of CWISE J0506+0738 using Keck/NIRES near-infrared spectroscopy and establish that it is a low-gravity, late-type L/T transition dwarf. The spectrum of CWISE J0506+0738 shows possible signatures of CH _4 absorption in its atmosphere, suggesting a colder effective temperature than other known, young, red L dwarfs. We assign a preliminary spectral type for this source of L8 γ –T0 γ . We tentatively find that CWISE J0506+0738 is variable at 3–5 μ m based on multiepoch WISE photometry. Proper motions derived from follow-up UKIRT observations combined with a radial velocity from our Keck/NIRES spectrum and a photometric distance estimate indicate a strong membership probability in the β Pic moving group. A future parallax measurement will help to establish a more definitive moving group membership for this unusual object

Overview of progress in European medium sized tokamaks towards an integrated plasma-edge/wall solution

\u3cp\u3eIntegrating the plasma core performance with an edge and scrape-off layer (SOL) that leads to tolerable heat and particle loads on the wall is a major challenge. The new European medium size tokamak task force (EU-MST) coordinates research on ASDEX Upgrade (AUG), MAST and TCV. This multi-machine approach within EU-MST, covering a wide parameter range, is instrumental to progress in the field, as ITER and DEMO core/pedestal and SOL parameters are not achievable simultaneously in present day devices. A two prong approach is adopted. On the one hand, scenarios with tolerable transient heat and particle loads, including active edge localised mode (ELM) control are developed. On the other hand, divertor solutions including advanced magnetic configurations are studied. Considerable progress has been made on both approaches, in particular in the fields of: ELM control with resonant magnetic perturbations (RMP), small ELM regimes, detachment onset and control, as well as filamentary scrape-off-layer transport. For example full ELM suppression has now been achieved on AUG at low collisionality with n = 2 RMP maintaining good confinement . Advances have been made with respect to detachment onset and control. Studies in advanced divertor configurations (Snowflake, Super-X and X-point target divertor) shed new light on SOL physics. Cross field filamentary transport has been characterised in a wide parameter regime on AUG, MAST and TCV progressing the theoretical and experimental understanding crucial for predicting first wall loads in ITER and DEMO. Conditions in the SOL also play a crucial role for ELM stability and access to small ELM regimes.\u3c/p\u3