Mindfulness Based Cognitive Therapy for tinnitus: Evaluation of long-term outcomes

Mindfulness Based Cognitive Therapy for tinnitus (MBCT-t) alleviates distress associated with tinnitus but long-term outcomes are unknown. A retrospective survey with people completing MBCT-t over the past nine years found that benefits often continued or improved for years after therapy. Qualitative analysis indicated that key changes supporting such improvements were a result of new, more helpful ways of responding to tinnitus, profound holistic benefits, reduced isolation and enhanced self-compassion and gratitude

Dispositional mindfulness, gratitude and self-compassion: factors affecting tinnitus distress

Objective: Evidence is growing in support of the benefits of ‘positive’ psychology qualities such as self-compassion, mindfulness and gratitude in mitigating distress and disability related to various chronic health conditions. These qualities have not yet been explored in people with tinnitus. This study aimed to test whether dispositional mindfulness, gratitude and self-compassion are related to distress in a tinnitus sample. Design: This cross-sectional study involved the completion of a battery of online questionnaires. Study sample: A total of 159 participants with tinnitus completed questionnaires assessing tinnitus severity, psychological distress, negative thoughts, mindfulness, gratitude and self-compassion. Results: There were significant associations between each of the constructs, tinnitus severity and psychological distress. Multiple regressions found that all three positive qualities contributed to variance in psychological distress. Post hoc analysis revealed an indirect effect of the three positive qualities on tinnitus severity and psychological distress, mediated by thoughts about tinnitus. Conclusions: Dispositional mindfulness, gratitude and self-compassion may play a role in distress experienced by people with tinnitus. Future research could explore the contribution of these qualities to distress in a help-seeking sample and whether interventions that enhance these qualities might lead to better clinical outcomes

The Dengue virus in Nepal: gaps in diagnosis and surveillance.

BACKGROUND: The introduction of the dengue virus (DENV) in Nepal is recent, first reports date back to 2004 from a Japanese traveller and limited information is available about DENV infection in the Nepali population. Within a decade after the first DENV detection, it is now endemic in multiple districts of Nepal with approximately 11.2 million people residing in the Terai belt being at risk of DENV infection. Sporadic cases of DENV infection have been reported every year for the past decade during the monsoon season, mainly in the Terai region. METHODS: Medline/Embase/Cochrane databases were reviewed for reports on the burden of dengue infection, diagnostic methods, and national surveillance. RESULTS: Four outbreaks were reported since 2004 including the diagnosis of all serotypes in 2006 and predominance of a single serotype in 2010 (DENV-1), 2013 (DENV-2), and 2016 (DENV-1). The clinical diagnoses showed a predominance of dengue fever while 4/917 (0.4%), 8/642 (1.2%) and 8/1615 (0.4%) dengue haemorrhagic fever/dengue shock syndrome cases were identified during the outbreaks in 2010, 2013 and 2016, respectively. The number of cases reported in males was significantly higher (67.4%) than in females. Disease occurrence was primarily found in the Terai region until 2010 and was increasingly detected in the Hilly region in 2016. CONCLUSION: In Nepal currently weak diagnostic facilities, very limited research on mosquitoes vectors, and poor surveillance of dengue leading to inappropriate detection and control of DENV. We surmise that improved basic research and epidemiological training courses for local scientists and laboratory personal at national and international level will help better understand the evolution and distribution of DENV transmission and its eventual control

What Have We Learned From the Typhoid Fever Surveillance in Africa Program?

The Typhoid Fever Surveillance in Africa Program (TSAP) was established in 2009 to fill the data void concerning invasive Salmonella disease in sub-Saharan Africa, and to specifically estimate the burden of bloodstream infections caused by the key pathogen, Salmonella enterica serovar Typhi. TSAP has achieved this ambitious target, finding high incidences of typhoid fever in both rural and urban populations in several countries in sub-Saharan Africa. The results of TSAP will undoubtedly dictate the direction of future typhoid fever research in Africa, and at last provides a key piece of the disease burden jigsaw puzzle. With the dawn of new Vi conjugate vaccines against Salmonella Typhi, the next priority for the typhoid community must be providing the required data on these vaccines so they can be licensed and provided to those in high-risk groups and locations across sub-Saharan Africa

Utilizzo di dati telerilevati nella mappatura e nel monitoraggio dei fenomeni franosi e nell’analisi della suscettibilità da frana

The recent advances in the optical satellites capabilities (e.g. high spatial resolution, stereoscopy), the development of new robust techniques based on the interferometric analysis of radar images, such as the Permanent Scatterers (PS) and the possibility of integrating these data within a Geographical Information System (GIS) have dramatically increased the potential of remote sensing for landslide investigations. The Arno river basin (Italy), with a spatial extension of about 9131 km2, has been chosen a as test area for the presence of a relevant number of mass movements (27270 landslides have been mapped by the institutional authorities by the end of 2004) and for its significance concerning the Italian Apennine territory. The aim of the research was to integrate the inventory maps produced through traditional methods with the information derived from the Permanent Scatterers standard interferometric analysis. The spatial significance of the PS point measures (about 600000 PS for the whole Arno river basin), also in terms of geological and geomorphological interpretation, was inferred with the help of optical satellite images and aerial-photos. This approach allowed the mapping of new unstable areas or the modification of boundaries and state of activity of existing landslides. The standard PS analysis was also employed for the validation of a statistically-based susceptibility map of the Arno river basin, through the analysis of predicted susceptibility over the areas identified as new landslides by the PS analysis. An advanced PS analysis, capable of detecting the time evolution of single important mass movements, was also applied over 4 test sites. The results for the Chianciano landslide are in particular presented. The integration of the advanced analysis with on siteal monitoring confirmed the inactivity of the principal landslide body but it revealed the presence of two possible minor movements

Efficacy of a bivalent killed whole-cell cholera vaccine over five years: a re-analysis of a cluster-randomized trial.

BACKGROUND: Oral cholera vaccine (OCV) is a feasible tool to prevent or mitigate cholera outbreaks. A better understanding of the vaccine's efficacy among different age groups and how rapidly its protection wanes could help guide vaccination policy. METHODS: To estimate the level and duration of OCV efficacy, we re-analyzed data from a previously published cluster-randomized, double-blind, placebo controlled trial with five years of follow-up. We used a Cox proportional hazards model and modeled the potentially time-dependent effect of age categories on both vaccine efficacy and risk of infection in the placebo group. In addition, we investigated the impact of an outbreak period on model estimation. RESULTS: Vaccine efficacy was 38% (95% CI: -2%,62%) for those vaccinated from ages 1 to under 5 years old, 85% (95% CI: 67%,93%) for those 5 to under 15 years, and 69% (95% CI: 49%,81%) for those vaccinated at ages 15 years and older. Among adult vaccinees, efficacy did not appear to wane during the trial, but there was insufficient data to assess the waning of efficacy among child vaccinees. CONCLUSIONS: Through this re-analysis we were able to detect a statistically significant difference in OCV efficacy when the vaccine was administered to children under 5 years old vs. children 5 years and older. The estimated efficacies are more similar to the previously published analysis based on the first two years of follow-up than the analysis based on all five years. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT00289224

Surge of Typhoid Intestinal Perforations as Possible Result of COVID-19-Associated Delays in Seeking Care, Madagascar.

During the coronavirus disease pandemic, we observed a 6.4-fold increase in typhoid intestinal perforation incidence in Antananarivo, Madagascar. Thirteen perforations occurred within 6 months (February 2020-July 2020), compared with 13 perforations during the previous 41 months (August 2016-January 2020). The increase may be attributable to delayed healthcare seeking during the pandemic