4 research outputs found
Polygenic burden in focal and generalized epilepsies
- Author
- Aarno Palotie (41342)
- Alexander W Smith (10534330)
- Bobby PC Koeleman (10490724)
- Ciaran Campbell (7896956)
- Costin Leu (7947866)
- Dennis Lal (455368)
- Epi25 Consortium (10534328)
- Gianpiero Cavalleri (7895525)
- Holger Lerche (455372)
- Imad M Najm (10534345)
- Lara Jehi (478348)
- Lea K Davis (10534342)
- Lisa Ferguson (10534338)
- Mark J Daly (4951582)
- Masahiro Kanai (10534335)
- Remi Stevelink (10534329)
- Robyn M Busch (10534347)
- Sanjay M Sisodiya (7947911)
- Slavina B Goleva (10534332)
- Yoichiro Kamatani (140517)
- Yukinori Okada (132408)
- Publication venue
- Publication date
- 04/05/2021
- Field of study
Rare genetic variants can cause epilepsy, and genetic testing has been widely adopted for severe, paediatric-onset epilepsies. The phenotypic consequences of common genetic risk burden for epilepsies and their potential future clinical applications have not yet been determined. Using polygenic risk scores (PRS) from a European-ancestry genome-wide association study in generalized and focal epilepsy, we quantified common genetic burden in patients with generalized epilepsy (GE-PRS) or focal epilepsy (FE-PRS) from two independent non-Finnish European cohorts (Epi25 Consortium, n = 5705; Cleveland Clinic Epilepsy Center, n = 620; both compared to 20 435 controls). One Finnish-ancestry population isolate (Finnish-ancestry Epi25, n = 449; compared to 1559 controls), two European-ancestry biobanks (UK Biobank, n = 383 656; Vanderbilt biorepository, n = 49 494), and one Japanese-ancestry biobank (BioBank Japan, n = 168 680) were used for additional replications. Across 8386 patients with epilepsy and 622 212 population controls, we found and replicated significantly higher GE-PRS in patients with generalized epilepsy of European-ancestry compared to patients with focal epilepsy (Epi25: P = 1.64Ă—10-15; Cleveland: P = 2.85Ă—10-4; Finnish-ancestry Epi25: P = 1.80Ă—10-4) or population controls (Epi25: P = 2.35Ă—10-70; Cleveland: P = 1.43Ă—10-7; Finnish-ancestry Epi25: P = 3.11Ă—10-4; UK Biobank and Vanderbilt biorepository meta-analysis: P = 7.99Ă—10-4). FE-PRS were significantly higher in patients with focal epilepsy compared to controls in the non-Finnish, non-biobank cohorts (Epi25: P = 5.74Ă—10-19; Cleveland: P = 1.69Ă—10-6). European ancestry-derived PRS did not predict generalized epilepsy or focal epilepsy in Japanese-ancestry individuals. Finally, we observed a significant 4.6-fold and a 4.5-fold enrichment of patients with generalized epilepsy compared to controls in the top 0.5% highest GE-PRS of the two non-Finnish European cohorts (Epi25: P = 2.60Ă—10-15; Cleveland: P = 1.39Ă—10-2). We conclude that common variant risk associated with epilepsy is significantly enriched in multiple cohorts of patients with epilepsy compared to controls-in particular for generalized epilepsy. As sample sizes and PRS accuracy continue to increase with further common variant discovery, PRS could complement established clinical biomarkers and augment genetic testing for patient classification, comorbidity research, and potentially targeted treatment
Corrigendum: Polygenic burden in focal and generalized epilepsies
- Author
- Aarno Palotie (41342)
- Alexander W Smith (10534330)
- Bobby PC Koeleman (10490724)
- Ciaran Campbell (7896956)
- Costin Leu (7947866)
- Dennis Lal (455368)
- Epi25 Consortium (10534328)
- Gianpiero Cavalleri (7895525)
- Holger Lerche (455372)
- Imad M Najm (10534345)
- Lara Jehi (478348)
- Lea K Davis (10534342)
- Lisa Ferguson (10534338)
- Mark J Daly (4951582)
- Masahiro Kanai (10534335)
- Remi Stevelink (10534329)
- Robyn M Busch (10534347)
- Sanjay M Sisodiya (7947911)
- Slavina B Goleva (10534332)
- Yoichiro Kamatani (140517)
- Yukinori Okada (132408)
- Publication venue
- Publication date
- 04/05/2021
- Field of study
The authors apologize for not including Appendix 1, listing the Epi25 Consortium collaborators. The authors also apologize for listing some collaborators incorrectly in the Supplementary material. These have been corrected
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Aarno Palotie (41342)
- Abraham Reichenberg (111006)
- Adam Savitz (2816050)
- Agnes A Steixner-Kumar (12556900)
- Agung Kusumawardhani (12556765)
- Aiden Corvin (221286)
- Alan R Sanders (12557083)
- Alessandra Frustaci (627712)
- Alessandro Bertolino (252850)
- Alessandro Serretti (127197)
- Alessia Fiorentino (337442)
- Alexander L Richards (12556639)
- Alice Braun (12464946)
- Alicia R Martin (12556807)
- Allen D Radant (12556855)
- Alp Ucok (12556933)
- Amanda L Neil (11362707)
- Amy Lynham (12556798)
- Ana Gonzalez-Pinto (3555599)
- Anders D Borglum (12557008)
- Andreas Forstner (8440308)
- Andres Metspalu (61760)
- Andrew J Pocklington (12557104)
- Andrew Mackinnon (194271)
- Andrew McIntosh (83234)
- Andrew McQuillin (82209)
- Andrey Khrunin (264236)
- Angele Consoli (12556699)
- Anil K Malhotra (8536308)
- Ann E Pulver (12556987)
- Ann Olincy (521692)
- Anna Gareeva (12557023)
- Anna K Kahler (12556750)
- Anna Rautanen (246408)
- Anna Waterreus (499361)
- Annette M Hartmann (12556741)
- Antonio F Pardinas (12556618)
- Antonio Julia (7437728)
- Antonio Rampino (562822)
- Arne Vaaler (525065)
- Ary Gadelha (291025)
- Assen Jablensky (176467)
- Atsushi Takahashi (128295)
- Ayman H Fanous (12557020)
- Bart PF Rutten (10260760)
- Beben Benyamin (75571)
- Behrooz Z Alizadeh (12556651)
- Bela Melegh (3999857)
- Benedicto Crespo-Facorro (757227)
- Benjamin M Neale (3809995)
- Bernard Lerer (188298)
- Bernhard T Baune (6568502)
- Bertram Muller-Myhsok (12556978)
- Bettina Konte (511722)
- Blanca Gutierrez (560875)
- Boris Chaumette (3924791)
- Bradley T Webb (12556936)
- Brandon K Wormley (12556945)
- Brian J Kelly (12556756)
- Brien P Riley (12557074)
- Brion S Maher (12556801)
- Bruce Turetsky (521701)
- Bruno Pfuhlmann (12556852)
- Bryan J Mowry (12557062)
- C Robert Cloninger (12556963)
- Carlos N Pato (12557071)
- Carmel M Loughland (12556795)
- Carmen Moreno (76007)
- Carol Harvey (9410305)
- Caroline Hayward (149856)
- Catherine A Sugar (12556912)
- Celso Arango (2937681)
- Charles Curtis (4634179)
- Charlotte A Dennison (12556627)
- Cherrie Galletly (4444402)
- Cheryl Roe (12556861)
- Chia-Yen Chen (489003)
- Chih-Min Liu (173117)
- Chikashi Terao (137128)
- Christian Benner (775884)
- Christina M Hultman (12557032)
- Christopher P Morley (12556822)
- Christos Pantelis (272264)
- Claudine Laurent-Levinson (12557047)
- Clement C Zai (3351386)
- Colm McDonald (12556813)
- Conrad Iyegbe (3129249)
- Cristiano Noto (519130)
- Dan Rujescu (109427)
- Daniel P Howrigan (12556747)
- Daniel R Weinberger (12557095)
- Danielle Posthuma (237783)
- David A Collier (12557017)
- David Braff (521682)
- David Castle (796181)
- David Cohen (133780)
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- Derek W Morris (12557059)
- Dheeraj Malhotra (246403)
- Diana O Perkins (12556849)
- Diego Quattrone (9960317)
- Dieter B Wildenauer (12557098)
- Digby Quested (82223)
- Dimitris Dikeos (665137)
- Ditte Demontis (469970)
- Dolores Malaspina (5082809)
- Dominique Campion (577036)
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- Elisabeth Stogmann (12556903)
- Elizabeth G Atkinson (12556642)
- Elliot S Gershon (12556714)
- Elvira Bramon (12037049)
- Elza Khusnutdinova (146583)
- Engilbert Sigurdsson (12556882)
- Enrico Domenici (128020)
- Eric FC Cheung (12556696)
- Eric Hahn (507071)
- Eric Strengman (155445)
- Erik G Jonsson (12557038)
- Erik Soderman (12556894)
- Esben Agerbo (95553)
- Espen Molden (3902095)
- Esther Molina (12556816)
- Evangelos Vassos (231278)
- Evelyn J Bromet (9610685)
- F Anthony O'Neill (12556837)
- Fabian Streit (3720028)
- Faith Dickerson (453082)
- Farooq Amin (12556660)
- Feng Zhu (685)
- Florence Thibaut (6174902)
- Frank Dudbridge (102283)
- Frank Koopmans (1710484)
- Frans A Henskens (12556744)
- Franziska Degenhardt (429524)
- Fritz Zimprich (12362)
- Gary Donohoe (503643)
- George Kirov (61612)
- George N Papadimitriou (12556846)
- Georgia Panagiotaropoulou (12556621)
- Georgios Voloudakis (7324955)
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- Hailiang Huang (211727)
- Hakon Hakonarson (102913)
- Hana Kuzelov A-Ptackova (12556768)
- Hannelore Ehrenreich (315807)
- Helen J Stain (12556897)
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- Henrik Walter (370898)
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- Jacob Gratten (3300798)
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- James TR Walters (12557116)
- Jan Lubinski (59925)
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- Javier Costas (232327)
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- Jeffrey Lieberman (12556786)
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- Jeremy M Silverman (12556993)
- Jian Yang (12136)
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- Jim van Os (114336)
- Jimmy Lee (446122)
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- John J McGrath (8674098)
- John Powell (237327)
- John Waddington (2903360)
- Jonas Bybjerg-Grauholm (2614411)
- Jonathan Pimm (82214)
- Jordan W Smoller (12556996)
- Jorge A Cervilla (12557014)
- Josef Frank (378047)
- Joseph D Buxbaum (12557011)
- Joshua L Roffman (12556864)
- Jouko Lonnqvist (12556792)
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- Kang Sim (335914)
- Kari Stefansson (26484)
- Keith H Nuechterlein (12556831)
- Kenneth L Davis (12556702)
- Kenneth S Kendler (12557110)
- Kieran C Murphy (12556828)
- Kimberley D Chambert (12556690)
- Koksal Alptekin (12556654)
- Kyoko Watanabe (5459522)
- Kyung Sue Hong (8912684)
- Larry J Seidman (12556873)
- Larry J Siever (12556879)
- Laura C Lazzeroni (12556771)
- Lavinia Athanasiu (721820)
- Liene Nikitina-Zake (264225)
- Lieuwe de Haan (51668)
- Lili Milani (73375)
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- Lourdes Martorell (7044902)
- Lynn E DeLisi (12556705)
- Lynsey S Hall (12556630)
- Madeline Alexander (12556648)
- Manuel Arrojo (423188)
- Manuel Mattheisen (170228)
- Mara Parellada (839497)
- Marcella Rietschel (128064)
- Marcos Leite Santoro (12556870)
- Margarita Rivera (12557077)
- Margot Albus (613068)
- Maria Dolores Molto (12556819)
- Maria Helena Azevedo (12556663)
- Mariam Al Eissa (12556645)
- Marianna Giannitelli (12556717)
- Marie-Odile Krebs (365386)
- Marina Mitjans (3161019)
- Mark Adams (26421)
- Mark H Rapaport (12556858)
- Mark J Daly (4951582)
- Mark Weiser (699679)
- Markus M Nothen (12557065)
- Marquis P Vawter (10275221)
- Marta Di Forti (3129243)
- Martin Begemann (5840690)
- Masashi Ikeda (162465)
- Massimo Gennarelli (239868)
- Matthew C Keller (12556753)
- Matthias Rothermundt (111333)
- Matthijs Verhage (67658)
- Matti Pirinen (415109)
- Max Lam (9721179)
- Menachem Fromer (5560)
- Meram C Saka (12557080)
- Merete Nordentoft (51499)
- Miaoxin Li (614827)
- Micha Gawlik (12557026)
- Michael C O'Donovan (12557119)
- Michael Davidson (699678)
- Michael F Green (12556729)
- Michael Gill (195307)
- Michael J Gandal (12556966)
- Michael J Owen (12557113)
- Michele T Pato (12556981)
- Michiaki Kubo (128298)
- Milan Macek (264249)
- Ming T Tsuang (12557092)
- Minh Tam Ta Thi (12556924)
- Minsoo Kim (171626)
- Monica E Calkins (12556684)
- Muhammad Ayub (582672)
- Murray J Cairns (7874447)
- Mythily Subramaniam (446121)
- Nakao Iwata (139930)
- Nancy G Buccola (12556954)
- Naomi R Wray (9279302)
- Neal R Swerdlow (12556918)
- Nelson B Freimer (12556711)
- Niamh Louise O'Brien (12556834)
- Nicholas J Bass (12556669)
- Nicholas J Bray (12556951)
- Nigel M Williams (12556939)
- Nikolay Kondratiev (12556759)
- Nils Eiel Steen (6094235)
- Nora Skarabis (12556885)
- Ole A Andreassen (5243117)
- Ole Mors (128054)
- Oleksandr Frei (6451931)
- Olivier Guillin (665136)
- Olli Pietilainen (5482613)
- Oussama Kebir (365383)
- Pablo Gejman (191172)
- Pak C Sham (12557089)
- Panos Roussos (318249)
- Paola Giusti-Rodriguez (3247965)
- Patricia T Michie (7874432)
- Patrick F Sullivan (8730545)
- Patrik KE Magnusson (3624236)
- Paul A Tooney (7874444)
- Paulo R Menezes (12557056)
- Per Hoffmann (429526)
- Peter A Holmans (12557101)
- Peter F Buckley (12556678)
- Peter M Visscher (12557107)
- Petr Slominsky (12556888)
- Phil H Lee (12556774)
- Preben B Mortensen (10806924)
- Qingqin S Li (12557053)
- Quirino Cordeiro (807336)
- Randy L Buckner (12556681)
- Raquel E Gur (12556735)
- Raquelle Mesholam-Gately (9598502)
- Raymond CK Chan (12556693)
- Rebecca Lencer (12556783)
- Renata Pellegrino (773084)
- Rene S Kahn (12557041)
- Richard A Belliveau (12556672)
- Richard Bruggeman (144361)
- Richard E Straub (12556906)
- Robert Freedman (521686)
- Robert W McCarley (12556810)
- Robert Yolken (104171)
- Robin M Murray (7955585)
- Rodney J Scott (5531030)
- Rodrigo Affonseca Bressan (7504037)
- Roel A Ophoff (8573757)
- Rolf Adolfsson (210493)
- Ruben C Gur (12556738)
- Ruud van Winkel (422356)
- Safaa Saker-Delye (12556867)
- Sally Isabel Sharp (12556876)
- Sandra Meier (573361)
- Sang-Yun Oh (12556840)
- Sara A Paciga (12557068)
- Sara Marsal (258049)
- Sarah E Bergen (12556675)
- Sarah Tosato (12556927)
- Sathish Periyasamy (478304)
- Sena Karachanak-Yankova (9416013)
- Shengying Qin (165450)
- Shi-Heng Wang (378857)
- Shuhua Xu (190024)
- Sibylle G Schwab (12557086)
- Sigurdur Magnusson (12556636)
- Silvia Torretta (716952)
- Silviu A Bacanu (12556666)
- Sinan Guloksuz (394950)
- Sintia Iole Belangero (12557005)
- Siow Ann Chong (8308434)
- Sophie E Legge (12556777)
- Srdjan Djurovic (170173)
- Srihari Gopal (2816062)
- Stanley Catts (12556687)
- Stefan Herms (429525)
- Stefano Bonassi (136975)
- Stefano Landi (511647)
- Stephan Ripke (156076)
- Stephanie Godard (12556720)
- Stephanie H Witt (12556942)
- Stephen Faraone (6158600)
- Stephen J Glatt (12557029)
- Stephen R Marder (12556804)
- Steven A McCarroll (12556972)
- Steven E Hyman (12557035)
- Sung-Wan Kim (112587)
- Sven Cichon (170294)
- Svetlana Limborska (264231)
- Swapnil Awasthi (11788712)
- T Scott Stroup (12556909)
- Therese van Amelsvoort (348773)
- Thomas D Als (12556657)
- Thomas G Schulze (12556990)
- Thomas Werge (170258)
- Tian Ge (369096)
- Tiffany A Greenwood (12556732)
- Tiina Paunio (130281)
- Tim B Bigdeli (12556624)
- Timothy Dinan (3930755)
- Ting Qi (537915)
- Todd Lencz (52220)
- Tonu Esko (3310785)
- Tony Kam-Thong (647240)
- Tracey L Petryshen (12556984)
- Ulrich Schall (581039)
- Vahram Haroutunian (23823)
- Vaidutis Kucinskas (3415886)
- Valentina Escott-Price (577023)
- Valeria Mondelli (3129255)
- Vanessa Kiyomi Ota (12556843)
- Vassily Trubetskoy (12556615)
- Vaughan J Carr (6060533)
- Veikko Salomaa (62543)
- Vera A Morgan (7040525)
- Vera Golimbet (5890595)
- Vihra Milanova (12045332)
- Vishwajit Nimgaonkar (116849)
- Volker Arolt (161757)
- Wei Cheng (52808)
- Wei J Chen (12556960)
- Wei Zhou (24328)
- Weihua Yue (102491)
- Wen Zhang (7555)
- Wiepke Cahn (155467)
- William F Byerley (12556957)
- William S Stone (7352516)
- Wolfgang Maier (128051)
- Xin Yu (124814)
- Yang Wu (66682)
- Yoichiro Kamatani (140517)
- Yongyong Shi (102679)
- Zhida Xu (2023525)
- Zhiqiang Li (102723)
- Zita Ausrele Kucinskiene (12556762)
- Publication venue
- Publication date
- 08/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies
COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19
- Author
- A Cerny (13566592)
- A Conen (13566478)
- A Guillet (13566487)
- A Munting (13566535)
- A Perret (13566628)
- Aarno Palotie (41342)
- Abdolmajid Hosseini (13566952)
- Abdulaziz AlMalik (5215085)
- Abdulraheem Alshareef (3532520)
- Achille Iolascon (206310)
- Adam S Butterworth (3810055)
- Afshar Etemadi Aleagha (13566937)
- Agnese Verzuri (13566721)
- Agostino Ognibene (5624702)
- Agostino Riva (393458)
- Ahmadreza Niavarani (711998)
- Ahna Girshick (13566238)
- Ahsan Khan (12068159)
- Aida Fiz-Lopez (13567297)
- Alba Parra Martinez (13567294)
- Albandary M Alowayn (13567099)
- Albert Smith (5520185)
- Albert Tenesa (107674)
- Alessandra Guarnaccia (13566751)
- Alessandra Renieri (383439)
- Alessandra Stella (28791)
- Alessandra Vergori (4540474)
- Alessandro Pancrazzi (13566727)
- Alessia Giorli (13566760)
- Alex Serra-Llovich (13567288)
- Alex Soriano (3091062)
- Alex Stuckey (13567192)
- Alexander Labkowsky (13567030)
- Alexander T Williams (8950472)
- Alexander W Charney (13567054)
- Alexandra Aksentijevich (13567027)
- Alexandre Belisle (13566310)
- Ali Amirsavadkouhi (13566931)
- Ali Sobh (13566367)
- Alice Donati (6876746)
- Alicia de Felipe Mimbrera (13567321)
- Alicia R Martin (12556807)
- Alireza Adamsara (13566946)
- Altaf Ali (13566445)
- Amal Al Mutairi (13567102)
- Amara Khan (10835145)
- Amin K Khattab (13567138)
- Amr M Yassen (13566409)
- Amr Samir (13566385)
- Amy Trankiem (13566163)
- Anastasia Lucas (3118140)
- Andre G Uitterlinden (8950781)
- Andrea Antinori (103654)
- Andrea Cossarizza (295123)
- Andrea Ganna (419008)
- Andrea Martin-Nalda (8583555)
- Andrea Tommasi (7884968)
- Andres Metspalu (61760)
- Andrew Beck (389972)
- Andrew P Boughton (13566916)
- Anil PS Ori (13566979)
- Ann E Woolley (13566982)
- Anna Canaccini (13566718)
- Anna Carreras (2111431)
- Anna Dominguez-Mayoral (13567327)
- Anna L Guyatt (8810699)
- Anna M Planas (8560464)
- Anna Maria Pinto (10764936)
- Annarita Giliberti (9265079)
- Anne E Justice (9357193)
- Anne Kallaste (13566439)
- Anne Marie O'Connell (13567225)
- Anne Richmond (5854361)
- Anne-Sophie Sauvage (11397734)
- Annique Claringbould (4798920)
- Anoud Albader (13567165)
- Antonella D'Arminio Monforte (13566733)
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- Sam Bryant (13566172)
- Sam Choi (1977952)
- Sameer Chavan (3947117)
- Sameera AlJohani (3632836)
- Sami Koskelainen (13566451)
- Samina Ashraf (13566868)
- Samira Azarzar (13566268)
- Samuli Ripatti (144251)
- Sandra P Smieszek (13567231)
- Sandro Mancarella (9467152)
- Sandro Panese (6444245)
- Sang Hyuck Lee (13566892)
- Sanni Ruotsalainen (13566448)
- Sara Alotaibi (13567108)
- Sara Amitrano (9656605)
- Sara Pigazzini (13566247)
- Sarah Alkwai (13567126)
- Sarah Finer (237152)
- Sarah G Earle (13567204)
- Sauro Luchi (13566805)
- Saverio Giuseppe Parisi (4026326)
- Scott T Weiss (9407556)
- Sebastian Garcia-Madrona (13567324)
- Sebastian Zollner (13566925)
- Semira Gonseth Nussle (13566460)
- Serafina Valente (3753733)
- Serena Ludovisi (13566814)
- Serghei Mangul (4973068)
- Sergio Daga (11283239)
- Seyed Behrooz Mohseni Moghaddam (13566943)
- Shaheen Akhtar (192582)
- Shang-Kuan Lin (13567207)
- Shannon McCurdy (11944312)
- Shapna Hussain (13566886)
- Shawn N Murphy (4802670)
- Shawneequa Callier (13567228)
- Shea J Andrews (13566199)
- Shefa Miah (13566901)
- Shefali S Verma (13567090)
- Shona M Kerr (8950520)
- Silvia Baroni (2156290)
- Silvia Cappelli (13566712)
- Silvia Rojo (13567306)
- Simona Dei (13566808)
- Simona Marcantonio (9656611)
- Simona Sarzi-Braga (13566784)
- Simone Furini (173392)
- Slayton J Underwood (13566208)
- Sophie Venturelli (9326809)
- Souad Rahmouni (320501)
- Spencer Knight (13566223)
- Stefania Mantovani (202342)
- Stefano Baratti (13566817)
- Stefano Busani (735718)
- Stefano Ceri (3614225)
- Stefano Rusconi (237803)
- Stephanie Bibert (316131)
- Stephanie Gofflot (790863)
- Stephen J Wicks (13566349)
- Steven Ascolillo (13566991)
- Stuart C Sealfon (13566205)
- Sulggi Lee (5979596)
- Susan Walker (469919)
- Susanna Croci (11283263)
- Susanna Guerrini (13566682)
- T Brahier (13566565)
- T Egger (13566625)
- T Rochat Negro (13566613)
- Tala Abdullah (10905739)
- Tamer A Elhadidy (13566376)
- Tess Levy (11503363)
- Thanyawee Puthanakit (615421)
- Thitima B Suttichet (13566961)
- Tim D Spector (8543481)
- Tiziana Bachetti (361249)
- Tom Fowler (3624713)
- Tomas Segura (13567309)
- Tomislav Maricic (178988)
- Tomoko Nakanishi (344291)
- Tonu Esko (3310785)
- Tooraj Mirshahi (547507)
- Tormod Rogne (4818324)
- Triin Laisk (6103775)
- Tullio Trotta (13566769)
- V D'Acremont (13566580)
- V Eric Kerchberger (13566334)
- V Suttels (13566547)
- Valentina Anemoli (13566724)
- Vasilios Polymeropoulos (13567237)
- Veronica Rico (13567261)
- Veronica Robles (7338719)
- Veronique Erard (13566466)
- Victor Moreno (748751)
- Vijay G Sankaran (13566175)
- Vincent Mooser (47546)
- Vincenzo Forgetta (756326)
- Voraphoj Nilaratanakul (13566964)
- Vorasuk Shotelersuk (581000)
- Walaa A Felemban (13567150)
- Walaa M El-Lawaty (13566397)
- Walid T Khafaga (13566394)
- Wanna Chetruengchai (9659225)
- Wanying Zhu (1567963)
- Watsamon Jantarabenjakul (9504660)
- WC Albrich (13566586)
- Wei Zhou (24328)
- Wenhan Lu (8908976)
- Werner Albrich (5541584)
- Xavier Farre (10317580)
- Xiao Chang (43560)
- Xiaoqing Xue (6116318)
- Xueyang Wang (6813818)
- Y Lannepoudenx (13566508)
- Yan Sun (22436)
- Yaseen M Arabi (12041017)
- Yasmine Belhaj (13566250)
- Yasser M El-Sherbiny (13566358)
- Yen-Chen Anne Feng (9983636)
- Yuk-Lam Ho (7010873)
- Yuki Bradford (496693)
- Yunsung Lee (10670517)
- Yuval Itan (260527)
- Yves Beguin (264097)
- Zaman Afrasiabi (10905751)
- Zeinab Naderpour (10054118)
- Ziab Z Alahmadey (13567144)
- Publication venue
- Publication date
- 03/08/2022
- Field of study
The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p