Association of the rs6232 and rs6235 with obesity in children and adult populations.

<p>Data are n (%). All odds ratios and <i>P</i>-values were calculated by logistic regression analyses using non-obese individuals as reference group, adjusting for age, sex and DT2. <i>P</i>_add, <i>P</i>-values for the additive model.</p

Glucose homeostasis parameters in nondiabetic children and adult populations according to <i>PCSK1</i> rs6232.

<p>Data are means ± s.d. or medians (interquantile range). <i>P</i>-values were calculated by generalized linear regression. BMI was adjusted for age and gender. Plasma glucose/insulin levels and HOMA indices were adjusted for age, gender and BMI. HOMA-B, homeostasis model assessment of beta-cell function; HOMA-S, homeostasis model assessment of insulin sensitivity.</p

Glucose homeostasis parameters in nondiabetic children and adult populations according to <i>PCSK1</i> rs6235.

<p>Data are means ± s.d. or medians (interquantile range). <i>P_add</i>_-values were calculated by generalized linear regression using an additive model. BMI was adjusted for age and gender. Plasma glucose/insulin levels and HOMA indices were adjusted for age, gender and BMI. HOMA-B, homeostasis model assessment of beta-cell function; HOMA-S, homeostasis model assessment of insulin sensitivity.</p

Characteristics of the cases and controls in the children and adult populations.

<p>Data are means ± s.d. or medians (interquantile range). HOMA-B, homeostasis model assessment of beta-cell function; HOMA-S, homeostasis model assessment of insulin sensitivity.</p

Associations of 12 loci with BMI and WC in Mexican Adults and Children.

<p>Abbreviations: Chr, chromosome; RAF, risk allele frequency; SE, standard error; <i>P</i>-Het, <i>P</i>-heterogeneity; BMI, body mass index; WC, waist circumference. Effect values are presented as effect size per allele copy, except for <i>ADIPOQ, BCDIN3</i>/<i>FAIM2</i> and <i>BDNF</i> analyzed under a recessive model, where effect size is reported for two allele copies. <i>P</i>-values were adjusted for age and sex. Statistically significant associations are bold-faced.</p

Associations of Candidate SNP loci with Obesity in the Mexican Population.

<p>Chr, chromosome; CI, confidence interval; OR, odds ratio; <i>P</i>-Het, <i>P</i>-heterogeneity. SNPs were ranked by <i>P</i>-values. Statistically significant associations are bold-faced. ^a<i>P</i>-values were adjusted for age and sex, and ^b<i>P</i>-values were further adjusted for admixture. All <i>P</i>-values were tested under an additive model (<i>P</i>_add), except those reported for <i>ADIPOQ</i>, <i>BCDIN3/FAIM2</i> and <i>BDNF</i> genes which were analyzed under a recessive model (<i>P</i>_rec).</p

Association of 12 loci with BMI in Indigenous Mexican population.

<p>Abbreviations: Chr, chromosome; RAF, risk allele frequency; SE, standard error; <i>P</i>-Het, <i>P</i>-heterogeneity; BMI, body mass index. Effect values are presented as effect size per allele copy, except for <i>ADIPOQ</i>, <i>BCDIN3</i>/<i>FAIM2</i> and <i>BDNF</i> analyzed under a recessive model, where effect size is reported for two allele copies. <i>P</i>-values were adjusted for age and sex. Statistically significant associations are bold-faced.</p

Additional file 1: of Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population

Panels of ancestry informative markers used for each cohort [18]. (DOC 30 kb