Reference invasive tests of microvascular injury in myocardial infarction

No abstract available

Expansion on the Use of the Novel Compound, ELP-004, Using a Mycobacterium tuberculosis Experimentation Model

Osteoarticular tuberculosis (OAT) is a bone degenerative disease that results in bone erosion, joint effusion, joint swelling, and sometimes, nerve compression. OAT occurs from the hematogenous dissemination of Mycobacterium tuberculosis (Mtb) bacilli spreading from the primary site of infection to the bones and joints; the primary site of infection tends to be the lungs as pulmonary tuberculosis infections are the most common. OAT can occur as the result of an active or latent infection. Latent infections result in OAT when bacilli are able to escape granulomas. The incidence of OAT is not as high as pulmonary infections, making up about 10- 15% of all extrapulmonary tuberculosis infections. Currently, the only treatment available for OAT is the standard regimen of care for treating tuberculosis; this includes 4-6 months of antibiotic treatment. Antibiotic treatment can be extended up to 12+ months for extrapulmonary TB. This does not resolve bone degeneracies or deformities that occur as a result of OAT. The novel compound, ELP-004, reduces bone erosion in mouse models of arthritis. To determine the effectiveness of ELP-004 in the treatment of OAT, a tuberculosis experimentation model was set up in vitro and in vivo. The in vivo model used RAW264.7 cells, a mouse monocyte/macrophage cell line commonly used to study osteoclastogenesis. RAW264.7 cells were exposed to extract from the H37Rv strain of Mtb did not result in TRAP positive syncytial formation; however, exposure to this TB extract still resulted in multinucleation. Cells exposed to Mtb extract also could not mobilize calcium matrices, and qPCR analysis revealed that osteoclast formation markers were absent. Although osteoclast-like cells could not be formed with this model, treatment with ELP- 004 resulted in a knockdown of syncytial cells, showing promise for its use in patients. Work on the in vitro model ceased to continue and a reevaluation of the model is necessary. Since ELP-004 was able to knockdown multinucleation in vitro, it was important to determine if the drug could be used in combination with current tuberculosis treatments. Using two first-line antibiotics, rifampin and isoniazid, the metabolism of combination therapy was assessed using cytochrome P450 enzymes (CYP). Cytochrome P450 enzymes are responsible for the metabolism of 90% of all drugs and xenobiotics. They are located primarily in the liver and are responsible for phase I metabolism. Of the CYPs tested, only Cyp1a2 and Cyp2b10 had increased mRNA expression. Using a western blot to confirm protein expression, only CYP2B10 showed increased protein expression. With this data, it can be concluded that CYP2B6, the human equivalent of CYP2B10, is the primary induced metabolic pathway for the combination therapy. These data combined show promise for using ELP-004 to treat bone erosion from a tuberculosis infection. The ability of ELP- 004 to inhibit increased osteoclastogenesis in an arthritis model can be expanded to prevent enhanced osteoclastogenesis in OAT

Teaching homophones in grades one, two and three

Thesis (Ed.M.)--Boston Universit

Evaluating The Efficacy of an Adaptation of PALS for Math in a Seventh Grade Classroom

In an attempt to validate and expand the potential application of PALS for math in a wider variety of settings, this research study examined the effects of implementing a modified version of PALS for math with seventh grade students in regular education mathematics classes. Utilizing a pre-post group design with a nested within-subject ABC single case design, the results of this study suggested that an adaptation of PALS for math for seventh grade students resulted in significant improvement in posttest mathematics computation performance within the experimental group when their pretest mathematics computation scores were considered as covariates. When comparing the performance of lower performing and higher-performing students, lower performing students demonstrated higher average weekly ROI in comparison to higher-performing students. The results of this study suggest that implementing an adaptation of PALS for math with seventh grade students systematically provides opportunities for all students to engage in mathematical computation practice and provides students with high levels of error correction and feedback. PALS for math provides educators with a supplementary intervention that helps to support groups of students with diverse levels of mathematics achievement. The limitations and implications for future research are considered

We must work hard to resist a fear of other people’s bodies

Relatively little attention has been paid to the loss of social spaces and its political and societal ramifications. Marie E. Berry and Milli Lake (LSE) remind us why it is important to remember the importance of physical touch, intimacy and connection to build community, practise resistance, heal from trauma and escape oppression

Imagining a distanced future: centring a politics of love in resistance and mobilisation

Globally we are witnessing and experiencing the many social implications of COVID-19, but less attention has been given to the loss of social spaces and the political and societal ramifications of this as we begin to navigate our reimagining of the ‘public space’. Marie E. Berry and Milli Lake remind us why it is important for us to remember the importance of physical touch, intimacy and connection to build community, practice resistance, heal from trauma and escape oppression

Validation and Improvement of the Beef Production Sub-index in Ireland for Beef Cattle

End of project reportThe objectives of the following study were to: a. Quantify the effect of sire genetic merit for BCI on: 1. feed intake, growth and carcass traits of progeny managed under bull or steer beef production systems. 2. live animal scores, carcass composition and plasma hormone and metabolite concentrations in their progeny. b. Compare the progeny of : 1. Late-maturing beef with dairy breeds and 2. Charolais (CH), Limousin (LM), Simmental (SM) and Belgian Blue (BB) sires bred to beef suckler dams, for feed intake, blood hormones and metabolites, live animal measurements, carcass traits and carcass value in bull and steer production systems

The Earned Income Tax Credit and Rural Families: Differences between Participants and Non-participants

The differences between rural low-income mothers who were participants and non-participants in the Earned Income Tax Credit (EITC) were examined. One-third of the 224 eligible mothers in a multi-state study did not claim the tax credit. Non-participants were more likely to be Hispanic, less educated, with larger families, borrowing money from family, and living in more rural counties. Participating mothers, on the other hand, were more food secure, perceived their household income as being adequate, reported recent improvements in their economic situation, were satisfied with life, and lived in states with a state EITC. Analysis of qualitative data revealed that rural mothers had many misconceptions about the EITC. These findings contribute to family and economic professionals’ understanding of why rural low-income families do not participate in the tax credit and assist in formulating policies and education/outreach efforts that would increase their participationEITC non-participants, EITC participants, rural low-income mothers, state EITC, rural low-income families

Linguistic Moments: Language, Teaching, and Teacher Education in the U.S.

This article was published in Educational Foundations, volume 23, issues 1-2, and was posted with permission from the publisher.Copyright © 2009, Caddo Gap Press. This article is not to be duplicated, distributed, or sold without specific permission from Caddo Gap Press.SJSU users: Use the following link to login and access the article via SJSU databases