Ingestion of NSAIDs a serios problem in young children

UMF Gr. T. Popa, Iasi, Romania, Conferința ştiinţifico-practică naţională cu participare internaţională ”Promovarea sănătăţii – o prioritate a sănătăţii publice” 22-24 iunie 2016 Chișinău, Republica Moldov

Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis

Background: We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH). Patients and methods: Data of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression. Results: We included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients. Conclusion: Baseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.Fil: Efe, Cumali. Harran University Hospita; TurquíaFil: Lammert, Craig. University School of Medicine Indianapolis; Estados UnidosFil: Taşçılar, Koray. Universitat Erlangen-Nuremberg; AlemaniaFil: Dhanasekaran, Renumathy. University of Stanford; Estados UnidosFil: Ebik, Berat. Gazi Yasargil Education And Research Hospital; TurquíaFil: Higuera de la Tijera, Fatima. Hospital General de México; MéxicoFil: Calışkan, Ali R.. No especifíca;Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Gerussi, Alessio. Università degli Studi di Milano; ItaliaFil: Massoumi, Hatef. No especifíca;Fil: Catana, Andreea M.. Harvard Medical School; Estados UnidosFil: Purnak, Tugrul. University of Texas; Estados UnidosFil: Rigamonti, Cristina. Università del Piemonte Orientale ; ItaliaFil: Aldana, Andres J. G.. Fundacion Santa Fe de Bogota; ColombiaFil: Khakoo, Nidah. Miami University; Estados UnidosFil: Nazal, Leyla. Clinica Las Condes; ChileFil: Frager, Shalom. Montefiore Medical Center; Estados UnidosFil: Demir, Nurhan. Haseki Training And Research Hospital; TurquíaFil: Irak, Kader. Kanuni Sultan Suleyman Training And Research Hospital; TurquíaFil: Melekoğlu Ellik, Zeynep. Ankara University Medical Faculty; TurquíaFil: Kacmaz, Hüseyin. Adıyaman University; TurquíaFil: Balaban, Yasemin. Hacettepe University; TurquíaFil: Atay, Kadri. No especifíca;Fil: Eren, Fatih. No especifíca;Fil: Alvares da-Silva, Mario R.. Universidade Federal do Rio Grande do Sul; BrasilFil: Cristoferi, Laura. Università degli Studi di Milano; ItaliaFil: Urzua, Álvaro. Universidad de Chile; ChileFil: Eşkazan, Tuğçe. Cerrahpaşa School of Medicine; TurquíaFil: Magro, Bianca. No especifíca;Fil: Snijders, Romee. No especifíca;Fil: Barutçu, Sezgin. No especifíca;Fil: Lytvyak, Ellina. University of Alberta; CanadáFil: Zazueta, Godolfino M.. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Demirezer Bolat, Aylin. Ankara City Hospital; TurquíaFil: Aydın, Mesut. Van Yuzuncu Yil University; TurquíaFil: Amorós Martín, Alexandra Noemí. No especifíca;Fil: De Martin, Eleonora. No especifíca;Fil: Ekin, Nazım. No especifíca;Fil: Yıldırım, Sümeyra. No especifíca;Fil: Yavuz, Ahmet. No especifíca;Fil: Bıyık, Murat. Necmettin Erbakan University; TurquíaFil: Narro, Graciela C.. Instituto Nacional de la Nutrición Salvador Zubiran; MéxicoFil: Bıyık, Murat. Uludag University; TurquíaFil: Kıyıcı, Murat. No especifíca;Fil: Kahramanoğlu Aksoy, Evrim. No especifíca;Fil: Vincent, Maria. No especifíca;Fil: Carr, Rotonya M.. University of Pennsylvania; Estados UnidosFil: Günşar, Fulya. No especifíca;Fil: Reyes, Eira C.. Hepatology Unit. Hospital Militar Central de México; MéxicoFil: Harputluoğlu, Murat. Inönü University School of Medicine; TurquíaFil: Aloman, Costica. Rush University Medical Center; Estados UnidosFil: Gatselis, Nikolaos K.. University Hospital Of Larissa; GreciaFil: Üstündağ, Yücel. No especifíca;Fil: Brahm, Javier. Clinica Las Condes; ChileFil: Vargas, Nataly C. E.. Hospital Nacional Almanzor Aguinaga Asenjo; PerúFil: Güzelbulut, Fatih. No especifíca;Fil: Garcia, Sandro R.. Hospital Iv Víctor Lazarte Echegaray; PerúFil: Aguirre, Jonathan. Hospital Angeles del Pedregal; MéxicoFil: Anders, Margarita. Hospital Alemán; ArgentinaFil: Ratusnu, Natalia. Hospital Regional de Ushuaia; ArgentinaFil: Hatemi, Ibrahim. No especifíca;Fil: Mendizabal, Manuel. Universidad Austral; ArgentinaFil: Floreani, Annarosa. Università di Padova; ItaliaFil: Fagiuoli, Stefano. No especifíca;Fil: Silva, Marcelo. Universidad Austral; ArgentinaFil: Idilman, Ramazan. No especifíca;Fil: Satapathy, Sanjaya K.. No especifíca;Fil: Silveira, Marina. University of Yale. School of Medicine; Estados UnidosFil: Drenth, Joost P. H.. No especifíca;Fil: Dalekos, George N.. No especifíca;Fil: N.Assis, David. University of Yale. School of Medicine; Estados UnidosFil: Björnsson, Einar. No especifíca;Fil: Boyer, James L.. University of Yale. School of Medicine; Estados UnidosFil: Yoshida, Eric M.. University of British Columbia; CanadáFil: Invernizzi, Pietro. Università degli Studi di Milano; ItaliaFil: Levy, Cynthia. University of Miami; Estados UnidosFil: Montano Loza, Aldo J.. University of Alberta; CanadáFil: Schiano, Thomas D.. No especifíca;Fil: Ridruejo, Ezequiel. Universidad Austral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Wahlin, Staffan. No especifíca

ASPECTS IN BIOMATERIALS SELECTION FOR REMOVABLE DENTURES – MARKER OF BIOLOGICAL INTEGRATION

The number of denture wearers is increasing as the number of elderly people continually growing, and polymethyl methacrylate (PMMA) is still the most frequently used material in denture base fabrication. It appears that the fiber impregnation method could positively affect the acrilic resin base resistance properties, preventing the dentures fracture. The association of acrilates with AM88-Natrium maleate copolymer, metil methacrylate produces positive antiseptic effects

OBTURATOR PROTHESIS, A CHALLENGE IN PROSTHODONTICS TERRITORY

Introducere Defecte maxilare sunt create de tratamentul chirurgical al neoplasmelor benigne sau maligne, malformații congenitale și de traume. Mărimea și localizarea defectelor influențează gradul de afectare și dificultate în reabilitare protetică. Lipsa de sprijin, de retenție, și stabilitatea sunt probleme comune de tratament protetice pentru pacientii care au avut un maxilectomie. Prezentare de caz Pacienta de sex feminin P.C in varsta de 48 de ani, a fost diagnosticata in anul 2006 in cadrul departamentului de Chirurgie OMF al Spitalului „Sf. Spiridon „ din Iasi cu Carcinom mucoepidermoid de bolta palatina, tratat prin rezectia chirurgicala, radioterapie si ulterior realizarea unei proteze obturator. Luand in considerare aspectul actual al cavitatii orale a pacientei, am hotarat sa realizam asanarea cavitatii orale si realizarea unei noi proteze obturator. Rezultate si discutii Rezultatul final al tratamentelor aplicate in Baza Clinica de Invatamant Stomatologic din Iasi a fost unul pozitiv, deoarece am reusit sa refacem functiile stistemului stomatognat. Concluzii Scopul acestei prezentari de caz este de a demonstra beneficiile și aplicabilitatea reabilitarii protetice maxilo-faciale adecvate. Planificarea tratamentului multidisciplinar este esențială pentru realizarea retenției și funcționalitatii adecvate a protezei. Acest raport clinic descrie o modalitate de realizare a protezei obturator maxilare, în condiții unei edentatii extinse maxilare, și o edentatie totală mandibulară în scopul de a obține de retenția optim

CARIOGENIC RISK IN CHILDREN WITH SEASONAL ALLERGIC RHINITIS

Introduction: Dental decay is one of the most common disorders of the oral-dental system, affecting 80-98% of the population. Identifying the factors that cause premature caries process has a significant impact in the success of specialized treatment. The purpose of the study is to assess caries risk to a group of children diagnosed with seasonal allergic rhinitis, in the context of salivary levels of MS. Material si method: 32 children aged between 7 and 12 years from rural areas take out with seasonal allergic rhinitis and under specific treatment, received dental checkup and determining the salivary level of MS using saliva kit Check Mutans. The working method included visual and tactile examination, recording individual data sheet and a questionnaire in which they were registered the dates for dental control presentation, oral hygiene habits and eating habits. Results and discussions: Saliva test made for assessing the level the MS was positive for all subjects, after its being placed in high caries risk category . It was found that subjects treated with Aerius shows a number of caries lesions smaller than those treated with histidine, but in addition, they have been identified with dental erosion. Conclusions: we can sustain that salivary level of SM is closely related to the occurrence of caries and caries risk increassement. Further studies are needed to demonstrate that treatment with Aerius and Histidine for children with seasonal allergic rhinitis affects the number of MS and increase caries risk by the appearance of new cavities lesions

CLINICAL ASPECTS OF THERAPEUTICAL SOLUTIONS INVOLVED IN ORAL REHABILITATION OF PARTIALLY EDENTULOUS PATIENTS

This study aims at identifying practical ways of approaching social cases, and creating a hierarchy of the final functions of restoration. In 2008 the Clinical Base for Learning from the Faculty of Dental Medicine, Iasi, recorded for the Partially Stretched Edentation Clinic and Therapy course a prevalence of biterminal partial edentation (Class I Kennedy)-66.39 per cent from the total number of patients, followed by uniterminal edentation (Class II Kennedy), having 40.24 per cent of the clinical cases, whereas INTERCALATE edentation (Class III Kennedy) , frontal edentation (Class IV Kennedy), and subtotal edentation have about 20.12.1 per cent each. The clinical form of edentation contributes to the election of a proper therapeutic solution as well as the odonto-parodontal and muco-osseous status of each clinical case, the patient’s general condition or the socio economic and technical factors leading to a modern, classical or social prosthesing. An important aspect to be taken into account is the large percentage of 41.61.2/ social cases diagnosed with partially edentation, pleading for provisional prostheses with an established role in therapy, which sometimes may become social prosthesing - an outstanding clinical reality. Social cases should be solved with a view to restoring functionality such as lower level redimensioning and cranio-mandibulary repositioning, whereas aesthetic requirements fall into therapies based on metallo-ceramic and hybrid prosthesing or implanto-prosthetic therapy

COMPARATIVE STUDY REGARDING SOURFACE ROUGHNESS OF DIFFERENT TYPES OF COMPOSITE RESINS AFTER FINISHING AND POLISHING METHODS AND GLAZE MATERIAL APPLICATION

Surface roughness is the major contributor for extrinsic discoloration of resin composite restorations. This property is closely related to the organic matrix, inorganic filler composition of the composite, and finishing and polishing procedures. Rough surface greater than 0.2 µm provides higher chances of biofilm accumulation, leading to staining and/or discoloration of the restoration’s body or margins. The purpose of the study was to compare the finishing and polishing technique of some composite resins with their sealing using a glaze material type, in terms of surface roughness. Materials and methods: 45 composite specimens were manufactured( ormocer- ADMIRA, nanohybrid – TETRIC EVOCERAM, nanocomposite – FILTEK ULTIMATE), and divided into 3 groups(n=15, control, polished and finished, and glaze material). Roughness(Ra) was messured before and after immersing in artificial saliva. For all composite resins the sourface roughness decreased after 90 days

PROBLEMS SOLVING IN COMPLETE DENTURES-AN OVERVIEW

Minimizing the problems related with complete denture treatment comprises of a triad that consists of the dentist, the patient and the dental laboratories. Every patient is unique, different in his own way from every other patient and, hence, there will be different achievement levels. Postplacement denture problems have been classified as incompatibility with the surrounding oral environment, problems with mastication, disharmony with functions like speech, respiration and deglutition, dissatisfaction with aesthetics and deterioration of soft tissues or bony support

ALTERNATIVE THERAPIES IN REDUCING ANXIETY AND PAIN FOR INVASIVE PROCEDURES IN PEDIATRIC PRACTICE

The multiple roles that music plays in our life, entertainment, inspiration, development of cognitive skills and improvement of psychomotor and socio-affective abilities extends to therapeutic effects. The physiological effect of music is reducing the level of stress hormones (cortisol and adrenaline) and releasing endorphins with calming and analgesic properties. An invasive medical procedure such as endoscopy, colonoscopy or surgery is a major factor for distress in children. Dental anxiety with a high prevalence in children has numerous negative effects and a proper management is required; non-pharmacological alternative treatments are studied lately. Many studies concluded that music therapy is useful in reducing nervousness and pain, improving blood pressure, cardiovascular parameters and oxygen saturation and in increasing cooperation and tolerance. Music might be successfully used as a non-invasive, non-pharmacological alternative method with multiple benefits and the potential to reduce major effects of invasive medical procedures in children

ORAL MANIFESTATIONS OF NURITIONAL DISEASES IN CHILDREN

Examination of the oral cavity can reveal signs and symptoms of immunologic diseases, endocrinopathies, hematologic conditions, systemic infections, and nutritional disorders. Iron deficiency anemia is present particularly in developing countries and characteristic oral manifestations include mucosal pallor, atrophic glossitis, and candidiasis. Vitamin D deficiency rickets occur in children between 3 months and 2 years old, as well as in teenagers during growth spurts which require high levels of calcium and phosphorus. The occurrence of cavities is also enabled by enamel dysplasia caused by malnutrition in the first years of life, this being a location of choice for the occurrence of cavities. Oral manifestations of malnutrition include aphthous stomatitis and atrophic glossitis caused by anemia and avitaminoses. The oral cavity plays an important part in many physiological processes represented by digestion, respiration and phonation. Oral signs frequently precede general symptoms. Physicians should be familiar with the relationship between systemic and oral health