Boletín de Segovia: Número 3 - 1917 enero 5

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

Additional file 4: of Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock

Demographic and baseline characteristics of the entire cohort according to the presence of acute kidney injury: the main demographic and baseline characteristics of the patients included in the FINNAKI genetic study. (DOC 86 kb

Number of subjects in mental health related phenotypes (DSM-IV based diagnoses and quantitative scores on psychometric scales) analyzed in the study.

<p>BDI; Beck Depression Inventory.</p><p>GHQ; General Health Questionnaire.</p><p>MBI; Maslach Burnout Inventory.</p><p>GSS; Global Seasonality Score.</p

Successfully genotyped SNPs, their selection criteria, allele and genotype frequencies, and Hardy-Weinberg equilibrium p-values.

<p>BP; Base pair position based on NCBI36/hg18 build.</p><p>A₁; Minor allele.</p><p>A₂; Major allele.</p><p>MAF; Minor allele frequency.</p><p>A₁A₁, A₁A₂, A₂A₂; genotype counts and frequencies (%).</p><p>HWE-P; Hardy-Weinberg equilibrium p-value.</p><p>LD; Linkage disequilibrium.</p><p>TFBS, Transcription factor binding site.</p

The analyzed <i>TTC1</i> SNPs, their location and the haplotype block structure constructed using the Haploview program showing r² values.

<p>The analyzed <i>TTC1</i> SNPs, their location and the haplotype block structure constructed using the Haploview program showing r² values.</p

Results from the single SNP association analyses (q<0.15).

<p>ADD; Additive model.</p><p>DOM; Dominant model.</p><p>A1; Tested allele (minor allele).</p><p>L95, U95; Lower and upper bounds of 95% confidence interval for odds ratio.</p>*<p>Significant association.</p

Results from the haplotype association analyses (p<0.10).

<p>NSNP; Number of SNPs in this haplotype.</p><p>NHAP; Number of common haplotypes (f>0.01).</p><p>SNP1; SNP ID of the first SNP (5′).</p><p>SNP2; SNP ID of the last SNP (3′).</p

Two-step cluster analysis of three phenotypic variables resulted in three significantly different clusters.

<p>Mean scores are represented as percentages of possible maximum points for each measurements. MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale.</p

Haplotype association tests on C3 phenotypic cluster in GLM and HapScore tests.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^a<i>p_model = 0.018</i>; GLM, general linear model.</p

Linkage disequilibrium map of the seven investigated SNPs.

<p>1 = rs4522666, 2 = rs6090378, 3 = rs3787138; 4 = rs1044396; 5 = rs3787140, 6 = rs2093107, 7 = rs755203.</p