Estradiol levels in women were obtained in the (early) follicular phase of the menstrual cycle.

<p>Testosterone levels in men were in the normal range (10–30 nmol/L). ND: not determined. Normal values for IGF-1 are age-dependent and range between 10–35 nmol/L. Normal free thyroxine levels (fT4) are between 10–22 nmol/L. The BMI levels are all within the non-obese range.</p

The association metrics in a system in which drives with a time lag of one and acts as an inhibitor when the concentration of exceeds a certain threshold such that the new pulses in are reduced by 90%.

<p>The association metrics in a system in which drives with a time lag of one and acts as an inhibitor when the concentration of exceeds a certain threshold such that the new pulses in are reduced by 90%.</p

Overview of association metrics of ACTH and TSH.

<p>The shaded area around the white lines marks the 95% confidence interval of the mean, the thin lines show the individual results. The metrics point at a relation at two optima at lags −42 and 22.</p

A concentration drop of below a certain threshold induces a pulse in .

<p>In AM3 and AM4 the solid line marks the conditioning on pulses of and the dashed line the pulses of .</p

Settings for the plaid algorithm.

*<p>Minimum of proportional reduction in residual sum of squares required for cluster membership.</p

Pulses in induce pulses in after 1 lag, without auxiliary (noise) pulses in .

<p>The solid black lines represent the cross correlation profiles after conditioning on , the dashed lines after conditioning on pulses in .</p

Overview of the metrics on the HPA axis hormones ACTH and cortisol.

<p>The shaded area around the white lines marks the 95% confidence interval of the mean, the thin lines show the individual results. The four metrics unanimously point to lag 1, but the different metrics center on different aspects of the relation between ACTH and cortisol.</p

The first 6 plaid components.

<p>Black squares indicate a +1, white indicates a zero. Results have been grouped as much as possible for clarity.</p

Determination of the optimal number of zeros for the first IDR component.

<p>The optimum is chosen where the angle between the simple component and principal components is minimal. This is indicated by a dotted line and an asterisk.</p

PCA solution.

<p>The values of the loadings are indicated by a grayscale color as indicated by the colorbar. The grouping of metabolites is identical to the grouping of the plaid solution for clarity.</p