Regional plots for the association of SNPs with MI in the region of <i>QKI</i>.

<p>Regional plots for the association of SNPs with MI in the region of <i>QKI</i>.</p

SNPs representing loci associated with circulating SHBG concentrations.

<p>All SNPs are on the+strand and positions are based on build 36. EAF = ‘effect allele frequency’. Beta units are per-allele effect estimates in natural log transformed nmol/L. Sex column gives the sex with the largest per-allele beta estimate. Missing values for conditional SNPs as sex-specific conditional analysis was not performed.</p

Allelic heterogeneity at the <i>SHBG</i> gene locus.

<p>There was significant allelic heterogeneity at the SHBG gene locus. The nine independent signals identified in the SHBG gene are shown in relation to their position within the gene. All positions based on build 36. Not all genes are shown.</p

Summary of the analytic plan.

<p>Summary of the analytic plan.</p

Statistically independent signals at the <i>SHBG</i> gene locus.

<p>All SNPs are on the+strand and positions are based on build 36. EAF = ‘effect allele frequency’. Beta units are per-allele effect estimates in natural log transformed nmol/L. ‘Full model’ SNPs were all included in a single regression model, where the effect estimates for each SNP are adjusted for the effect of the others in the model.</p><p>‘Conditional’ SNPs are SNPs with low pair-wise LD (HapMap r²<0.01) that were identified after conditioning on the full model SNPs.</p

Study design for identification and validation of SNPs associated with MI and CHD.

<p>Study design for identification and validation of SNPs associated with MI and CHD.</p

Association of the known SNPs for coronary artery disease with incident MI and CHD in Stage I.

<p>Association of the known SNPs for coronary artery disease with incident MI and CHD in Stage I.</p

Association of the known SNPs for coronary artery disease with mortality after MI.

<p>Association of the known SNPs for coronary artery disease with mortality after MI.</p

Description and association of top SNPs with incident MI and CHD in Stage II and their combined results with Stage I.

<p>Description and association of top SNPs with incident MI and CHD in Stage II and their combined results with Stage I.</p

Manhattan plot of the autosomal SNPs identified in the GWA meta-analysis.

<p>The Manhattan plot depicts the SNPs identified in the GWAS analysis labeled with the nearest gene on the plot. The SNP identified on the X chromosome, rs1573036, at Xq22.3, is not included in this figure.</p