Characteristics of significant LOD-score loci identified by genome-wide linkage in the MO1 family.

<p>The flanking SNPs are the first ones outside the LOD_max peak, defined as having a LOD-scoremax-2 or LOD-scoremax-1. The Homozyg. line indicates whether the linkage peak was detected as a run of shared homozygosity by the KinSNP analysis.</p

Clinical and genetic data for the MO1 POF patients included in the study.

<p>Clinical and genetic data for the MO1 POF patients included in the study.</p

Whole genome linkage analysis for the MO1 family.

<p>The multipoint parametric LOD-score is plotted against the physical location of markers along the genome. The chromosome number is indicated in the upper part of the graph. Genotype analysis was performed on the Affymetrix GeneChip® Human Mapping 250 K <i>Nsp</i> Array (Affymetrix Inc., Santa Clara, CA). A significant LOD-score was obtained for two regions on chromosome 7. The apparent single peak on chromosome 13 encompasses two distinct very small peaks.</p

Table S2 from Association of <i>FOXD1</i> variants with adverse pregnancy outcomes in mice and humans

Primer sequence

Figure S1 from Association of <i>FOXD1</i> variants with adverse pregnancy outcomes in mice and humans

FKHD binding sites are more abundant in placenta down-regulated genes in the 66H-Chr13 strai

Table S2 from Association of <i>FOXD1</i> variants with adverse pregnancy outcomes in mice and humans

Primer sequence

Table S1 from Association of <i>FOXD1</i> variants with adverse pregnancy outcomes in mice and humans

Number of FKHD binding sites in the promoters of modified gene