57 research outputs found

    Coupling the non-gravitational forces and Modified Newton Dynamics for cometary orbits

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    In recent work (Milgrom 2009, Blanchet & Novak 2011), the authors showed that MOdified Newton Dynamics (MOND) have a non-negligible secular perturbation effect on planets with large semi-major axes (gaseous planets) in the Solar System. Some comets also have a very eccentric orbit with a large semi-major axis (Halley family comets) going far away from the Sun (more than 15 AU) in a low acceleration regime where they would be subject to MOND perturbation. They also approach the Sun very closely (less than 3 AU) and are affected by the sublimation of ices from their nucleus, triggering so-called non-gravitational forces. The main goal of this paper is to investigate the effect of MOND perturbation on three comets with various orbital elements (2P/Encke, 1P/Halley and 153P/Ikeya-Zhang) and then compare it to the non-gravitational perturbations. It is motivated by the fact that when fitting an outgassing model for a comet, we have to take into account all of the small perturbing effects to avoid absorbing these effects into the non-gravitational parameters. Otherwise, we could derive a completely wrong estimation of the outgassing. For this work, we use six different forms of MOND functions and compute the secular variations of the orbital elements due to MOND and non-gravitational perturbations. We show that, for comets with large semi-major axis, the MONDian effects are not negligible compared to the non-gravitational perturbations

    A reversible posterior leucoencephalopathy syndrome including blindness caused by preeclampsia.

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    Complications of (pre)eclampsia may involve multiple systems and organs. Neurological symptoms may occur. Visual symptoms concern up to 25% the of patients with severe preeclampsia and 50% of the patients with eclampsia. An uncommon effect of severe preeclampsia is sudden blindness. Blindness may be part of a clinical and radiological presentation named Posterior Reversible Encephalopathy Syndrome (PRES). PRES may lead to permanent neurological deficit, recurrences or death. We report the case of a 24-year-old Caucasian patient, gravida 5 para 2 who developed preeclampsia and PRES complicated with blindness at 32 weeks of gestation. Optimal care allowed visual symptoms to resolve within 24 hours and a favourable maternal outcome and no long- term sequelae. We describe different causes and manifestations of PRES and highlight the need for immediate care in order to optimize the chance of symptoms reversibility

    Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review.

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    peer reviewedOpportunistic viral infections of the central nervous system represent a significant cause of morbidity and mortality among an increasing number of immunocompromised patients. Since antiviral treatments are usually poorly effective, the prognosis generally relies on the ability to achieve timely immune reconstitution. Hence, strategies aimed at reinvigorating antiviral immune activity have recently emerged. Among these, virus-specific T-cells are increasingly perceived as a principled and valuable tool to treat opportunistic viral infections. Here we briefly discuss how to develop and select virus-specific T-cells, then review their main indications in central nervous system infections, including progressive multifocal leukoencephalopathy, CMV infection, and adenovirus infection. We also discuss their potential interest in the treatment of progressive multiple sclerosis, or EBV-associated central nervous system inflammatory disease. We finish with the key future milestones of this promising treatment strategy
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