Effects of tryptophan deficiency, CUS and regular exercise on latency time to re-enter a dark compartment in the passive avoidance test.

<p>Data are expressed as mean ± SEM. *, p<0.05 vs. TD+CUS, TD+CUS+IE; §, p<0.05 vs. TD+CUS+IE; #, p<0.05 vs. TD, TD+CUS, TD+CUS+ME, TD+CUS+IE.</p

Effects of tryptophan deficiency, CUS and regular exercise in FST (a) and SFT (b).

<p>Data are expressed as mean ± SEM. *, p<0.05 vs. C; <b>§</b>, p<0.05 vs. TD; #, p<0.05 vs. TD+CUS; †, p<0.05 vs. TD+CUS+ME.</p

Effects of tryptophan deficiency, CUS and regular exercise on number of BrdU-positive cells in the dentate gyrus of the hippocampus.

<p>Data are expressed as mean ± SEM. *, p<0.05 vs. C; §, p<0.05 vs. TD; #, p<0.05 vs. TD+CUS.</p

Experimental procedures.

<p>Habituation: habituation to cage, food and treadmill running; CUS: chronic unpredictable stress; PAT: passive avoidance test; ORT: object recognition test; SFT: sucrose preference test; FST: forced swimming test.</p

Effects of tryptophan deficiency, CUS and regular exercise on number of Ki67-positive cells in the dentate gyrus of the hippocampus.

<p>Data are expressed as mean ± SEM. *, p<0.05 vs. C; §, p<0.05 vs. TD; #, p<0.05 vs. TD+CUS.</p

Protocol of chronic unpredictable stress.

<p>Protocol of chronic unpredictable stress.</p

Effects of tryptophan deficiency, CUS and regular exercise on recognition index in object recognition.

<p><b>Data are expressed as mean ± SEM.</b> *, p<0.05 vs. C; #, p<0.05 vs. TD.</p

Effects of tryptophan deficiency, CUS and regular exercise on body weight.

<p>Data are expressed as mean ± SEM. *, p<0.05 vs. TD, TD+CUS, TD+CUS+ME, TD+CUS+IE; •, C; ▪, TD; <b>○</b>, TD+CUS; ▴, TD+CUS+ME; △, TD+CUS+ IE.</p

Effects of tryptophan deficiency, CUS and regular exercise on the levels of tryptophan (a), 5-HT (b) and noradrenaline (c) in the hippocampus.

<p>Data are expressed as mean ± SEM. *_, p<0.05 vs. C; #, p<0.05 vs. C, TD, TD+CUS.</p

Additional file 3: Figure S1. of A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas

Distributions of molecular alterations according to histology in Cohort 1. Figure S2. Kaplan-Meier analysis for Group A cases stratified by 1p/19q status. Figure S3. Kaplan-Meier analyses for GBM cases in Cohorts 1 and 2. (PPTX 172 kb