Additional file 1: of Correlation between patients’ reasons for encounters/health problems and population density in Japan: a systematic review of observational studies coded by the International Classification of Health Problems in Primary Care (ICHPPC) and the International Classification of Primary care (ICPC)

Table S1. Details of included studies. (XLSX 18 kb

Results of the multiple linear regression analysis with the stepwise method in which the average ocular surface displacement at the time of IOP reading was the outcome variable.

<p>Predictors were selected from among CCT, age, gender, SE, the radius of ocular curvature and the IOP obtained using the Goldmann applanation tonometer.</p

The relationship between the ocular surface displacement at the IOP reading time and IOP.

<p>The amount of ocular surface displacement at the IOP reading time showed a significant positive correlation with the IOP obtained using the non-contact tonometer (R² = 0.1187, <i>P</i> = 0.007).</p

The average of central ocular surface displacement of subjects.

<p>Contact lens use changes the amount of ocular surface displacement.</p

The relationship between the radius ocular surface and IOP.

<p>The radius ocular curvature showed a significant negative correlation with the IOP obtained using the non-contact tonometer (R² = 0.0443, <i>P</i> = 0.028).</p

Results of the multiple linear regression analysis with the stepwise method in which the IOP obtained by non-contact tonometry was the outcome variable.

<p>Predictors were selected from CCT, age, gender, SE, radius of ocular curvature, IOP obtained by Goldmann applanation tonometer, the ocular surface displacement at IOP reading time and the maximal ocular surface displacement time.</p

Comparison of ocular surface displacement at 14.8

<p>*Significant difference for CL −5 D and CL +5 D at the IOP reading time (<i>P</i> = 0.003) and maximum displacement (<i>P</i><0.0001).</p>†<p>Significant difference for NCL and CL +5 D at maximum displacement (<i>P</i><0.0001).</p>‡<p>Significant difference for CL −5 D and CL −0.5 D at maximum displacement (<i>P</i> = 0.043).</p>§<p>Significant difference for CL +5 D and CL −0.5 D at maximum displacement (<i>P</i> = 0.0002).</p

Results of the multiple linear regression analysis with the stepwise method in which the maximal ocular surface displacement was the outcome variable.

<p>Results of the multiple linear regression analysis with the stepwise method in which the maximal ocular surface displacement was the outcome variable.</p

The values are presented as the means ± standard deviations.

<p>W/M, women/men.</p

Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel

We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified HA conjugated with PolyP (HA-PolyP). Although the gelation rate decreased with increasing PolyP content, the gelation time was below 5 min. In addition, the hydrogel swelling volume decreased with increasing PolyP content, but the degradation rate did not depend on PolyP content and the hydrogel underwent complete degradation through hydrolysis over 3 weeks in phosphate buffered saline. HAX-PolyP showed similar biocompatibility with the HA hydrogel without PolyP conjugation in vitro and in vivo. Intraperitoneal administration of HAX-PolyP did not induce any adhesion in the peritoneum and clot formation in the lungs. Finally, HA-PolyP accelerated the coagulation rate of human plasma ex vivo, and HAX-PolyP showed as strong a hemostatic effect as fibrin glue in a mouse liver bleeding model in vivo