Quantile-Quantile(QQ) plots on SNP set enrichment.

<p>QQ-plots of SNP set enrichment test. Solid line represents normal distribution and black dots represent data distribution of p-values for eSNPs representing genes within the gene set of interest. Deviation of the data from the solid line indicates a non-normal distribution. Plots are shown for the top ranking gene sets A: published mRNA profiling signatures from infarcted tissue and B: implicated causal genes from the Global Lipid Genetics GWAS Consortium.</p

Mean (±SD) numbers of heterozygous loci among CHD cases and controls and odds ratios (95% confidence interval) for CHD associated with heterozygous loci.

<p>Odds ratios adjusted for age, smoking, and population eigenvectors.</p><p>Mean (±SD) numbers of heterozygous loci among CHD cases and controls and odds ratios (95% confidence interval) for CHD associated with heterozygous loci.</p

Association of CHD risk factors with overall heterozygous loci, loci within genes, and nonsynonymous SNPs.

<p>All estimates adjusted for age, smoking, population eigenvectors, and case-control status.</p><p>Association of CHD risk factors with overall heterozygous loci, loci within genes, and nonsynonymous SNPs.</p

Flow chart of participants from invitation to analyses.

<p>The following chronic diseases were excluded: diabetes (any diabetes diagnosis), acute myocardial infarction, stroke, and cancer. “Outside the workforce” refers to participants who are either unemployed or retired. Because participants must necessarily participate in the second examination to be included in the analysis of changes in total cycling, flow of participants for this analysis is shown following those who participate in the second examination.</p

Baseline characteristics of sample according to level of total cycling.

<p>Baseline characteristics of sample according to level of total cycling.</p

Associated risk of T2D according to changes in total cycling from baseline to the second examination.

<p>Associated risk of T2D according to changes in total cycling from baseline to the second examination.</p

Associated risk of T2D according to level of commuter cycling.

<p>Associated risk of T2D according to level of commuter cycling.</p

Distribution of exposure variables according to case status.

<p>Medians with 10th and 90th percentiles in brackets for continuous variables. Absolute numbers and/or percentages for discrete variables. Diet, Cancer and Health, Health Professionals Follow-up Study (HPFS), and Nurses’ Health Study (NHS).</p><p>Note: Sample size in NHS and HPFS with data available on waist and hip circumfererence was lower (426/679 and 382/821, resspectively).</p

RR^* with 95% confidence interval in brackets for the combined effect of abdominal obesity and the NFKB1-94ATTG polymophism in relation to acute coronary syndrome.

<p>Diet, Cancer and Health, Health Professionals Follow-up Study (HPFS), and Nurses Health Study (NHS).</p><p>¹Adjusted for age, smoking status, alcohol consumption, physical activity, educational level, and hip circumference. Women also adjusted for menopausal status.</p><p>²Adjusted for age, smoking status, alcohol consumption, physical activity, and hip circumference. Women also adjusted for menopausal status and hormone replacement therapy.</p>*<p>RR estimated by Cox proportional hazards regression in DCH and logistic regression in NHS and HPFS.</p

Baseline characteristics of controls and cases of acute coronary syndrome.

<p>Medians with 10th and 90th percentiles in brackets for continuous variables. Percentages for discrete variables. Diet, Cancer and Health, Health Professionals Follow-up Study (HPFS), and Nurses’ Health Study (NHS).</p><p>¹Self reported hypertension or reporting to use blood pressure lowering medication.</p><p>²Self reported or reporting to use antidiabetic medications.</p><p>³Self reported hypercholesterolemia or reporting to use cholesterol lowering medication.</p