2 research outputs found
Synthesis and Conformational Dynamics of the Reported Structure of Xylopyridine A
Natural
products have served as a rich source for the discovery
of new nucleic acid targeting molecules for more than half a century.
However, our ability to design molecules that bind nucleic acid motifs
in a sequence- and/or structure-selective manner is still in its infancy.
Xylopyridine A, a naturally occurring molecule of unprecedented architecture,
has been found to bind DNA by a unique mode of intercalation. Here
we show that the structure proposed for xylopyridine A is not consistent
with the characterization in the original isolation report and does
not bind B-form DNA. Instead, we report that the originally proposed
structure for xylopyridine A represents a new class of conformationally
dynamic structure-selective quadruplex nucleic acid binder. The unique
molecular conformation locks out nonspecific intercalative binding
modes and provides a starting point for the design of a new class
of structure-specific nucleic acid binder
Synthesis and Conformational Dynamics of the Reported Structure of Xylopyridine A
Natural
products have served as a rich source for the discovery
of new nucleic acid targeting molecules for more than half a century.
However, our ability to design molecules that bind nucleic acid motifs
in a sequence- and/or structure-selective manner is still in its infancy.
Xylopyridine A, a naturally occurring molecule of unprecedented architecture,
has been found to bind DNA by a unique mode of intercalation. Here
we show that the structure proposed for xylopyridine A is not consistent
with the characterization in the original isolation report and does
not bind B-form DNA. Instead, we report that the originally proposed
structure for xylopyridine A represents a new class of conformationally
dynamic structure-selective quadruplex nucleic acid binder. The unique
molecular conformation locks out nonspecific intercalative binding
modes and provides a starting point for the design of a new class
of structure-specific nucleic acid binder