Whereabouts you are

•‘Whereabouts you are’ was an exhibition of work by ten Glasgow School of Art PhD Researchers, curated by Allyson Keehan (Glasgow School of Art) and guest curator Viviana Checchia (Centre for Contemporary Arts) • The exhibition ran from Saturday 15th October to Thursday 10th November in The Reid Gallery, Glasgow School of Art ‘Whereabouts you are’ explored the diverse research practices of the Glasgow School of Art PhD cohort. Bringing together researchers from disciplines across the fields of Fine Art and Design, the exhibition posed a number of questions about the role of arts practice in academic research, its unique character, and its particular challenges. For the exhibiting researchers, pinpointing whereabouts you are is about marking a particular moment in the research process, pausing to reflect and take stock of their individual journey so far and to consider the next steps. In that spirit, rather than deferring the questions posed by the exhibition, they tackled them head-on through accompanying events organised in collaboration with the Centre for Contemporary Arts. By bringing their work out of the studio, the group hoped to not only shed light on the thought-provoking and innovative research undertaken at Glasgow School of Art, but to enliven the research through conversation with its new audience. The exhibiting researchers were: • Eszter Biró (School of Fine Art) • Jacqueline Butler (School of Fine Art) • Mirian Calvo (Institute for Design Innovation) • Inês Bento Coelho (School of Fine Art) • Allyson Keehan (School of Fine Art) • Fiona Jane MacLellan (Institute for Design Innovation) • Catherine M. Weir (School of Fine Art) • Dawn Worsley (School of Fine Art) • Hanan Makki Zakari (School of Simulation and Visualisation) • Polina Zioga (School of Simulation and Visualisation). Curated by Allyson Keehan (Glasgow School of Art) and guest curator Viviana Checchia (Centre for Contemporary Arts)

Whereabouts you are

'Whereabouts you are' was an exhibition of work by ten Glasgow School of Art Ph.D. Researchers, curated by Allyson Keehan (Glasgow School of Art) and guest curator Viviana Checchia (Centre for Contemporary Arts Glasgow). The exhibition ran from Saturday 15th October to Thursday 10th November 2016 in The Reid Gallery, Glasgow School of Art. 'Whereabouts you are' explored the diverse research practices of the Glasgow School of Art Ph.D. cohort. Bringing together researchers from disciplines across the fields of Fine Art and Design, the exhibition posed a number of questions about the role of arts practice in academic research, its unique character, and its particular challenges. For the exhibiting researchers, pinpointing 'whereabouts you are' is about marking a particular moment in the research process, pausing to reflect and take stock of their individual journey so far and to consider the next steps. In that spirit, rather than deferring the questions posed by the exhibition, they tackled them head-on through accompanying events organised in collaboration with the Centre for Contemporary Arts Glasgow. By bringing their work out of the studio, the group hoped to not only shed light on the thought-provoking and innovative research undertaken at Glasgow School of Art, but to enliven the research through conversation with its new audience. The exhibiting researchers were: • Eszter Biró (School of Fine Art) • Jacqueline Butler (School of Fine Art) • Mirian Calvo (Institute for Design Innovation) • Inês Bento Coelho (School of Fine Art) • Allyson Keehan (School of Fine Art) • Fiona Jane MacLellan (Institute for Design Innovation) • Catherine M. Weir (School of Fine Art) • Dawn Worsley (School of Fine Art) • Hanan Makki Zakari (School of Simulation and Visualisation) • Polina Zioga (School of Simulation and Visualisation)

Heterogeneous HER2 Gene Amplification Impact on Patient Outcome and a Clinically Relevant Definition

Heterogeneous expression or amplification is a challenge to HER2 diagnostics. A guideline defines heterogeneity as the presence of between 5% and 50% cells with HER2/CEP17 ratios of more than 2.20. We audited the frequency of such cells and their clinical impact in the results from 2 pathology laboratories combined with data from the TEAM [Tamoxifen vs Exemestane Adjuvant Multicentre] pathology study. HER2 reports were scanned and the percentages of amplified cells reported. Of 6,461 eligible cases, 754 (11.7%) exhibited 50% or more cells with ratios of more than 2.20, which is “amplified” by College of American Pathologists guidelines. Of the cases, 2,166 (33.5%) exhibited more than 5% but less than 50% of cells with HER2/CEP17 ratios of more than 2.20, or “heterogeneous amplification.” No prognostic impact was observed when fewer than 30% of cells exhibited ratios of more than 2.20. All amplified cases with 30% to 50% of cells with ratios more than 2.20 were identified as such by United Kingdom guidelines. The percentage of tumor cells with HER2/CEP17 ratios more than 2.20 does not identify cases with heterogeneous amplification or poor outcome. A modified approach for identification of true heterogeneous amplification is suggested