Tornado diagram of the one-way sensitivity analyses of TBE burden expressed in total DALYs from the population perspective.

<p>Tornado diagram of the one-way sensitivity analyses of TBE burden expressed in total DALYs from the population perspective.</p

Comparison of relative TBE burden expressed in total DALYs from the population perspective with the relative TBE burden expressed by the number of reported cases by age groups.

<p>DALYs and reported cases are averages over 2004–2011.</p

Trend analysis of TBE burden expressed in total DALYs in years 2004 to 2011 from the population perspective.

<p>Trend analysis of TBE burden expressed in total DALYs in years 2004 to 2011 from the population perspective.</p

Schematic presentation of disease progression, used to estimate the factors β_r, β_a and consequently γ; with γ (4.5) to correct under-estimation of the reported number of cases with the acute disease of the second stage (n_ra) resulting from the product of a factor β_a (100/40 = 2.5) to correct for under-ascertainment and a factor β_r (100/55 = 1.8) to correct for under-reporting.

<p>Schematic presentation of disease progression, used to estimate the factors β_r, β_a and consequently γ; with γ (4.5) to correct under-estimation of the reported number of cases with the acute disease of the second stage (n_ra) resulting from the product of a factor β_a (100/40 = 2.5) to correct for under-ascertainment and a factor β_r (100/55 = 1.8) to correct for under-reporting.</p

Cumulative ascending curve of the probabilistic sensitivity analysis of TBE burden expressed in total DALYs from the population perspective, reflecting the likelihood (y-axis) of being below a specified total DALYs impact (x-axis).

<p>Cumulative ascending curve of the probabilistic sensitivity analysis of TBE burden expressed in total DALYs from the population perspective, reflecting the likelihood (y-axis) of being below a specified total DALYs impact (x-axis).</p

Perspective and category of included costs.

<p>Perspective and category of included costs.</p

Characteristics of the included studies.

<p>Characteristics of the included studies.</p

Diabetes related costs for patients with complications and related diseases (USD).

<p>Diabetes related costs for patients with complications and related diseases (USD).</p

CHEERS checklist per item for all included studies in the review.

<p>CHEERS checklist per item for all included studies in the review.</p

Methodological characteristics and results of the included studies.

<p>Methodological characteristics and results of the included studies.</p