Influence of vitamin K antagonist treatment on activated partial thromboplastin time

A

Table ronde« Qu’est-ce qui fait bouger les services publics ? »(UFR INFOCOM – 6 avril 2000)

Les discours qui eurent lieu lors de la table ronde "Qu'est-ce qui fait bouger les services publics?" organisée à l'UFR INFOCOM de l'Université de Lille 3 en partenariat avec l'association "Réseau de service public du Nord-Pas-de-Calais" sont ici retranscrits. Quatre sujet sont abordés autour de la notion d'usager des services publics : l'amélioration de l'accueil de l'usager aux services fiscaux du Nord-Lille, l'acceuil à la Mairie de Douai, le forum-douleur de l'hôpital de Douai et l'usager au coeur de la modernisation

Influence of platelet count in platelet rich plasma for adenosine triphosphate release assay

C

Isolated acquired factor VII deficiency : review of the literature

Objectives: Isolated acquired factor VII (FVII) deficiency is a rare haemorrhagic disorder. We report what is currently known about the pathogenesis, clinical features, diagnosis, treatment and prognosis of acquired FVII deficiency. Methods: We performed a literature search and included all articles published between 1980 and August 2015. Results and Conclusions: Acquired FVII deficiency has been reported in 42 patients. There are well-established clinical diseases associated with acquired FVII deficiency, most notably infections, malignancy and haematological stem cell transplantation. The exact pathogenesis of the diseases is still unknown, but different pathophysiological hypotheses have been suggested. The clinical manifestation of acquired FVII deficiency varies greatly in severity; asymptomatic course as well as severe life-threatening bleeding diathesis and fatal bleedings have been described

Acquired hemophilia: a case report and review of the literature

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against clotting factor VIII (FVIII). FVIII autoantibody is characterized as polyclonal immunoglobulin G directed against the FVIII procoagulant activity. This disease occurs most commonly in the elderly population and with preponderance of men in nonpregnancy-related AHA. There are well-established clinical associations with AHA such as malignancy, other autoimmune diseases and pregnancy. However, up to 50% of reported cases remain idiopathic. The clinical manifestation of AHA includes mostly spontaneous hemorrhages into skin, muscles and soft tissues, or mucous membranes. AHA should be suspected when a patient with no previous history of bleeding presents with bleeding and an unexplained prolonged activated partial thromboplastin time. The diagnosis is confirmed in the laboratory by the subsequent identification of reduced FVIII levels and FVIII inhibitor titration. There is a high mortality, making prompt diagnosis and treatment vitally important. The principles of treatment consist in controlling the bleeding and eradicating the inhibitor. Because of the overall high relapse rate (15-33%), it is also recommended to follow up these patients. The review summarizes what is currently known about the epidemiology, pathogenesis, clinical features, diagnosis, treatment and prognosis of AHA and starts with a case report