Latest nuclear emulsion technology

Nuclear emulsion is a extremely high-resolution 3D tracking detector. Since the discovery of the pion by C.F. Powell et al. in 1946, experiments with nuclear emulsions have contributed to the development of particle physics. (e.g. the OPERA collaboration reported the discovery of νμ * ντ oscillations in appearance mode in 2015) The technology of nuclear emulsion still keeps making progress. Since 2010, we have introduced a system of nuclear emulsion gel production to our laboratory in Nagoya University, and have started self-development of the new gel, instead of from the photographic film companies. Moreover, a faster automated emulsion scanning system is developed. Its scanning speed reaches 4000 cm2/h, and the load for analyzing becomes more and more lighter. In this presentation, we report the status of nuclear emulsion technologies for cosmic ray experiments

Latest nuclear emulsion technology

Nuclear emulsion is a extremely high-resolution 3D tracking detector. Since the discovery of the pion by C.F. Powell et al. in 1946, experiments with nuclear emulsions have contributed to the development of particle physics. (e.g. the OPERA collaboration reported the discovery of νμ * ντ oscillations in appearance mode in 2015) The technology of nuclear emulsion still keeps making progress. Since 2010, we have introduced a system of nuclear emulsion gel production to our laboratory in Nagoya University, and have started self-development of the new gel, instead of from the photographic film companies. Moreover, a faster automated emulsion scanning system is developed. Its scanning speed reaches 4000 cm2/h, and the load for analyzing becomes more and more lighter. In this presentation, we report the status of nuclear emulsion technologies for cosmic ray experiments

Latest nuclear emulsion technology

Nuclear emulsion is a extremely high-resolution 3D tracking detector. Since the discovery of the pion by C.F. Powell et al. in 1946, experiments with nuclear emulsions have contributed to the development of particle physics. (e.g. the OPERA collaboration reported the discovery of νμ * ντ oscillations in appearance mode in 2015) The technology of nuclear emulsion still keeps making progress. Since 2010, we have introduced a system of nuclear emulsion gel production to our laboratory in Nagoya University, and have started self-development of the new gel, instead of from the photographic film companies. Moreover, a faster automated emulsion scanning system is developed. Its scanning speed reaches 4000 cm2/h, and the load for analyzing becomes more and more lighter. In this presentation, we report the status of nuclear emulsion technologies for cosmic ray experiments

Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein.

Drug-drug interaction was suggested to have played a role in the recent death due to cardiac arrest of a patient taking pimozide, sertraline and aripiprazole antipsychotic/antidepressant combination therapy. Here, we investigated the possible involvement of P-glycoprotein (P-gp)-mediated interaction among these drugs, using in vitro methods. ATPase assay confirmed that pimozide is a P-gp substrate, and might act as a P-gp inhibitor at higher concentrations. The maximum transport rate (Jmax) and half-saturation concentration (Kt) for the carrier-mediated transport estimated by means of pimozide efflux assay using P-gp-overexpressing LLC-GA5-CoL150 cells were 84.9 ± 8.9 pmol/min/mg protein, and 10.6 ± 4.7 μM, respectively. These results indicate that pimozide is a good P-gp substrate, and it appears to have the potential to cause drug-drug interactions in the digestive tract at clinically relevant gastrointestinal concentrations. Moreover, sertraline or aripiprazole significantly decreased the efflux ratio of pimozide in LLC-GA5-CoL150 cells. Transport studies using Caco-2 cell monolayers were consistent with the results in LLC-GA5-CoL150 cells, and indicate that P-gp-mediated drug-drug interaction may occur in the gastrointestinal tract. Thus, P-gp inhibition by sertraline and/or aripiprazole may increase the gastrointestinal permeability of co-administered pimozide, resulting in an increased blood concentration of pimozide, which is known to be associated with an increased risk of QT prolongation, a life-threatening side effect

Cosmic ray nuclei detection in the balloon borne nuclear emulsion gamma ray telescope flight in Australia (GRAINE 2015)

Nuclear emulsion plates for studying elementary particle physics as well as cosmic ray physics are very powerful tracking tools with sub-micron spatial resolutions of charged particle trajectories. Even if gamma rays have to be detected, electron-positron pair tracks can provide precise information to reconstruct their direction and energy with high accuracy. Recent developments of emulsion analysis technology can digitally handle almost all tracks recorded in emulsion plates by using the Hyper Track Selector of the OPERA group at NAGOYA University. On the other hand, the potential of time resolutions have been equipped by emulsion multilayer shifter technology in the GRAINE (Gamma Ray Astro-Imager with Nuclear Emulsion) experiments, the aims of which are to detect cosmic gamma rays such as the Vela pulsar stellar object by precise emulsion tracking analysis and to study cosmic ray particle interactions and chemical compositions. In this paper, we focus on the subject of cosmic ray nuclei detection in the GRAINE balloon flight experiments launched at Alice Springs, Australia in May 2015

Cosmic ray nuclei detection in the balloon borne nuclear emulsion gamma ray telescope flight in Australia (GRAINE 2015)

Nuclear emulsion plates for studying elementary particle physics as well as cosmic ray physics are very powerful tracking tools with sub-micron spatial resolutions of charged particle trajectories. Even if gamma rays have to be detected, electron-positron pair tracks can provide precise information to reconstruct their direction and energy with high accuracy. Recent developments of emulsion analysis technology can digitally handle almost all tracks recorded in emulsion plates by using the Hyper Track Selector of the OPERA group at NAGOYA University. On the other hand, the potential of time resolutions have been equipped by emulsion multilayer shifter technology in the GRAINE (Gamma Ray Astro-Imager with Nuclear Emulsion) experiments, the aims of which are to detect cosmic gamma rays such as the Vela pulsar stellar object by precise emulsion tracking analysis and to study cosmic ray particle interactions and chemical compositions. In this paper, we focus on the subject of cosmic ray nuclei detection in the GRAINE balloon flight experiments launched at Alice Springs, Australia in May 2015