Toxicology and farmacology of phosphamidon

Fosfamidon izaziva tipične simptome otrovanja antiholinesterazama. Subletalne doze fosfamidona proizvode kod miševa i štakora značajnu ali relativno kratkotrajnu inhibiciju kolinesteraze u krvi i mozgu. Antiholinesteraznom dejstvu fosfamidona može se pripisati i najveći broj njegovih farmakoloških efekata na anestetisanim životinjama i izolovanim organima. Istraženo je terapeutsko dejstvo atropina i TMB-4, danih odvojeno ili zajedno, na životinjama otrovanim fosfamidonom. Utvrđeno je da je njihovo terapeutska dejstvo mnogo jače kada se apliciraju simultano nego kad se daju odvojeno.Phosphamidon produces typical symptoms of anticholinesterase poisoning. Sublethal doses of phosphamidon given to mice and rats produce a pronounced but comparatively short cholinesterase inhibition in the blood and brain. The highest number of the therapeutical and pharmacological effects of phosphamidon observed both on anaesthetized animals and isolated organs can be attributed to the anticholinesterase activity of phosphamidon. The therapeutic effect of atropine and TMB-4 is studied. When given simultaneously, their therapeutic effect is much higher than when given separately

The Surface of Sodium Tungsten Bronze Electrodes in Acid Solutions

At eledtrddes of sodium tungsten bronzes · of CJWic> syi;r;imetpy (0:25 hydraW,d\u27 laye~ of rion-stoiehiotnetric oxide· is.Jormed, On ·the \u27·base o0f comwn·ative considerations of results of electrochemical and: .some ; othevr me:;i~u:. . remerits the structure •of the ··surface layer is .• ptQposed,· ,a_nd, the thiekfiess\u27 . of . the. isur\u27:flace layer• eS>timated,; •Rossiblgru.eNplanati-on:s.ef\u27 •the nature• of · the rest potential arid ·N ~ .log i· ,relationship :are po1nted \u27 out; On the base\u27 .of study of • kinetics. and · mechanism,. of some simple electron exchange reactions . it \u27is concluded ·:that elei:;trical properties of the surface layer are close to· metallic

Supplementary material for the article: Savić, N. D.; Vojnovic, S.; Glišić, B. Đ.; Crochet, A.; Pavic, A.; Janjić, G. V.; Pekmezović, M.; Opsenica, I. M.; Fromm, K. M.; Nikodinovic-Runic, J.; et al. Mononuclear Silver(I) Complexes with 1,7-Phenanthroline as Potent Inhibitors of Candida Growth. Eur. J. Med. Chem. 2018, 156, 760–773. https://doi.org/10.1016/j.ejmech.2018.07.049

Supplementary data for: [https://doi.org/10.1016/j.ejmech.2018.07.049]Research data for this article: [https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc1zdr7c&sid=DataCite]Research data for this article: [https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc1zdr6b&sid=DataCite]Research data for this article: [https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc1zdr59&sid=DataCite]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2213]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/2993

Supplementary material for the article: Savić, N. D.; Vojnovic, S.; Glišić, B. Đ.; Crochet, A.; Pavic, A.; Janjić, G. V.; Pekmezović, M.; Opsenica, I. M.; Fromm, K. M.; Nikodinovic-Runic, J.; et al. Mononuclear Silver(I) Complexes with 1,7-Phenanthroline as Potent Inhibitors of Candida Growth. Eur. J. Med. Chem. 2018, 156, 760–773. https://doi.org/10.1016/j.ejmech.2018.07.049

Supplementary data for: [https://doi.org/10.1016/j.ejmech.2018.07.049]Research data for this article: [https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc1zdr7c&sid=DataCite]Research data for this article: [https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc1zdr6b&sid=DataCite]Research data for this article: [https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc1zdr59&sid=DataCite]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2213]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/2993

On the kinetics of the hydrogen evolution reaction on nickel in alkaline solution - Part I. The mechanism

The mechanism and kinetics of the hydrogen evolution reaction (her) were studied in 1.0 mol dm(-3) NaOH at 393.0 K. It was found that a combination of classical steady-state voltammetry and impedance spectroscopy can help to elucidate dilemmas concerning the role of the Heyrovsky and Tafel steps in the mechanism of this reaction. Thus, within the potential region - 0.95 gt E gt - 1.1 V (SHE) (curvilinear part of the polarization curve) the mechanism of the her is a consecutive combination of the Volmer step, followed dominantly by a rate controlling Tafel step, while the contribution of the parallel Heyrovsky step is negligible. At potentials E lt (approximately - 1.2 V) a Tafel line with a slope of - 0.121 V dec(-1) is obtained, with almost full coverage by H-ads ( lt theta gt (H) -- gt 1). In this potential region the mechanism of the her is a consecutive combination of a Volmer step, followed by a Heyrovsky step, while the contribution of the Tafel step is negligible. The comparison of the calculated partial rate constants for these two steps shows that the rate of the her is controlled by the Heyrovsky step

Hydrogen evolution reaction from EDTA solutions

An attempt was made to investigate the mechanism and kinetics of hydrogen evolution reaction on zinc and platinum wire electrodes from solutions containing ethylene diamine tetraacetic acid (EDTA). EDTA is a tetra-basic acid whose dissociation covers a wide range of pH, with a betaine structure in solutions. Introduction of EDTA into the solution provided several species whose dissociative hydrogen could be a source of h.e.r. The effect of EDTA concentration and pH on the Tafel dependence of cathode process was studied by galvanostatic method and cyclic voltametry. The aim was to establish the effect of EDTA on hydrogen evolution at the electrodes, i.e. whether evolution of hydrogen proceeds via hydronium ions arising from dissociation of EDTA, EDTA anions or hydrogen atoms transferred to the metal from EDTA molecules, as well as the impact of the Rowland effect on h.e.r

Structural characterization and biological evaluation of polynuclear Mn (II) and Cd(II) complexes with 2,2-dimethyl-1,3-propanediamine-N,N,N ', N '-tetraacetate. The influence of ligand structure and counter cation on the complex nuclearity

New polynuclear manganese(II) and cadmium(II) complexes with 2,2-dimethyl-1,3-propanediamine-N,N, N',N'-tetraacetato ligand (2,2-diMe-1,3-pdta), {Ba[M(2,2-diMe-1,3-pdta)]center dot 3H(2)O}(n) (M = Mn (1) or Cd (2)) were synthesized and characterized by IR spectroscopy and single-crystal X-ray diffraction analysis. In addition, complex 2 was characterized by solution H-1 and C-13 NMR spectroscopy. Crystallographic analysis showed that 2,2-diMe-1,3-pdta ligand is hexadentately coordinated to each M(II) ion through the two nitrogen and four carboxylate oxygen atoms, whereas the one of these oxygen atoms is also involved in coordination to the second M(II) ion of the dinuclear [M-2(2,2-diMe-1,3-pdta)(2)](4-) unit in polymeric structures. Moreover, three of four carboxylic groups of 2,2-diMe-1,3-pdta ligand are additionally bonded to four Ba(II) ions, in three distinctive bridging coordination modes. Each Ba(II) ion is surrounded by ten oxygen atoms, seven belonging to carboxylate groups of 2,2-diMe-1,3-pdta, and three belonging to water molecules. The coordination environment around Mn(II) and Cd(II) ions could be assigned as a face capped octahedron, while coordination polyhedron around Ba(II) ion in these two complexes was described as a distorted sphenocorona. The antimicrobial potential of complexes 1 and 2 and corresponding metal salts used for their synthesis was evaluated against different bacterial and Candida spp. Both complexes showed selective antifungal activity against the tested Candida spp. compared to the bacterial strains, with the minimal inhibitory concentration (MIC) values in the range 3.12 - 12.50 mu M. Moreover, complex 1 caused the slightly decrease of hyphae length, while no significant influence on hyphal length of complex 2 was observed. With aim to assess the therapeutic profile of the complexes, their cytotoxicity was evaluated against the normal human lung fibroblast cell line (MRC-5)

Sinteza i elektrohemijska svojstva polipirola, polianilina i poli-3-metiltiofena

In this article, the results of a study of the electrochemical polymerization of pyrrole and the chemical polymerization of pyrrole, aniline and 3-methyl thiophene initiated by FeCh are presented. The electrochemical properties of the synthesized electron conducting polymers (polypyrrole, polyaniline and poly 3-methyl thiophene) were measured. A new reactor for the synthesis of polypyrrole at a constant initiator concentration - K3Fe(CN)e - was developed and for the first time corresponding constants of the pyrrole polymerization reaction were determined. It has been proved that polypyrrole and polyaniline can be used as electrode materials for positive electrodes in lithium rechargeable power sources and that thin layers of these polymers can be successfully applied for the corrosion protection of iron.U okviru ovoga rada prikazani su rezultati dobijeni izučavanjem elektrohemijski inicirane polimerizacije pirola i hemijski inicirane oksidativne polimerizacije pirola, anilina i 3-metiltiofena sa FeCb, kao i elektrohemijskih svojstava sintetizovanih elektroprovodnih polimera. Razvijen je novi reaktor za sintezu polipirola pri konstantnoj koncentraciji inicijatora - K3Fe(CN)6 i po prvi put određene odgovarajuće konstante polimerizacije pirola. Pokazano je da polipirol i polianilin mogu da se primenjuju kao elektrodni materijali za obnavljajuće izvore električne struje i da tanki slojevi ovih polimera mogu uspešno da se koriste za zaštitu gvožđa od korozije