ВНУТРИПОЛОСТНАЯ ТЕРАПИЯ ОЗОНИРОВАННЫМ АНТИСЕПТИЧЕСКИМ РАСТВОРОМ В КОМПЛЕКСНОМ ЛЕЧЕНИИ ПАЦИЕНТОВ С ИНФИЦИРОВАННЫМИ ПОЛОСТНЫМИ ОБРАЗОВАНИЯМИ ПЕЧЕНИ

Application   in  the   treatment of  patients  with  infected  cavitary  formations  liver intracavitary therapy ozonated antiseptic allowed  significantly  speed  up the  recovery  of liver function, reduce  the  time of hospital  treatment, to accelerate the  elimination  of the abscess  cavity.Применение в лечении у пациентов с инфицированными полостными образованиями печени внутриполостной терапии озонированным антисептическим раствором позволило достоверно ускорить  восстановление функции печени,  уменьшить сроки стационарного лечения, ускорить ликвидацию полости абсцесса

ЭТИОЛОГИЧЕСКИЕ ФАКТОРЫ РАЗВИТИЯ АБСЦЕССОВ ПЕЧЕНИ

Liver abscesses of various origins are the group of severe purulent diseases of the liver and it is considered one of the difficult problems of the hepatobiliary system. The article presents the current data on the causes and microbiological composition of pathogens liver abscesses.Абсцессы печени различного генеза являются группой тяжелых гнойных заболеваний печени и считаются одной из сложных проблем гепатобилиарной системы. В статье приведены современные данные о причинах развития и микробиологическом составе возбудителей абсцессов печени

INTRACAVITARY THERAPY BY THE OZONIZED ANTISEPTIC SOLUTION IN COMPLEX TREATMENT OF PATIENTS WITH INFECTED BAND FORMATIONS OF THE LIVER

Application   in  the   treatment of  patients  with  infected  cavitary  formations  liver intracavitary therapy ozonated antiseptic allowed  significantly  speed  up the  recovery  of liver function, reduce  the  time of hospital  treatment, to accelerate the  elimination  of the abscess  cavity

CAUSES OF DEVELOPMENT LIVER ABSCESSES

Liver abscesses of various origins are the group of severe purulent diseases of the liver and it is considered one of the difficult problems of the hepatobiliary system. The article presents the current data on the causes and microbiological composition of pathogens liver abscesses

Structure and Network Performance

Networks have become a widely utilized method for dealing with emergencies and disasters. Researching this aspect of the emergency management process can effectively contribute to the outcome of disaster response and recovery by providing insight into the operations and processes of disaster management as well as ways to better utilize network resources and relationships. This article compares vertical and horizontal networks using the example of two counties in Florida. Understanding these network approaches contributes to efficient emergency management networks, thus strengthening outcomes in disaster response and recovery. The findings offer practical implications for local-level emergency management agencies

Peritoneal flap for lymphocele prophylaxis following robotic-assisted laparoscopic radical prostatectomy with pelvic lymph node dissection: study protocol and trial update for the randomized controlled PELYCAN study

Background!#!Data from interventional studies suggest that a peritoneal flap after pelvic lymph node dissection (LND) during laparoscopic, robotic-assisted radical prostatectomy (RARP) may reduce the rate of symptomatic lymphoceles in transperitoneal approach. However, most of these studies are not conducted in a randomized controlled fashion, thus limiting their scientific value. A recent prospective, randomized, controlled trial (RCT) did not show superiority of a peritoneal flap while further trials are lacking. Therefore, the aim of the presented RCT will be to show that creating a peritoneal flap decreases the rate of symptomatic lymphoceles compared to the current standard procedure without creation of a flap.!##!Methods/design!#!PELYCAN is a parallel-group, patient- and assessor-blinded, phase III, adaptive randomized controlled superiority trial. Men with histologically confirmed prostate cancer who undergo transperitoneal RARP with pelvic LND will be randomly assigned in a 1:1 ratio to two groups-either with creating a peritoneal flap (PELYCAN) or without creating a peritoneal flap (control). Sample size calculation yielded a sample size of 300 with a planned interim analysis after 120 patients, which will be performed by an independent statistician. This provides a possibility for early stopping or sample size recalculation. Patients will be stratified for contributing factors for the development of postoperative lymphoceles. The primary outcome measure will be the rate of symptomatic lymphoceles in both groups within 6 months postoperatively. Patients and assessors will be blinded for the intervention until the end of the follow-up period of 6 months. The surgeon will be informed about the randomization result after performance of vesicourethral anastomosis. Secondary outcome measures include asymptomatic lymphoceles at the time of discharge and within 6 months of follow-up, postoperative complications, mortality, re-admission rate, and quality of life assessed by the EORTC QLQ-C30 questionnaire.!##!Discussion!#!The PELYCAN study is designed to assess whether the application of a peritoneal flap during RARP reduces the rate of symptomatic lymphoceles, as compared with the standard operation technique. In case of superiority of the intervention, this peritoneal flap may be suggested as a new standard of care.!##!Trial registration!#!German Clinical Trials Register DRKS00016794 . Registered on 14 May 2019