On stepdown control of the false discovery proportion

Consider the problem of testing multiple null hypotheses. A classical approach to dealing with the multiplicity problem is to restrict attention to procedures that control the familywise error rate ($FWER$), the probability of even one false rejection. However, if $s$ is large, control of the $FWER$ is so stringent that the ability of a procedure which controls the $FWER$ to detect false null hypotheses is limited. Consequently, it is desirable to consider other measures of error control. We will consider methods based on control of the false discovery proportion ($FDP$) defined by the number of false rejections divided by the total number of rejections (defined to be 0 if there are no rejections). The false discovery rate proposed by Benjamini and Hochberg (1995) controls $E(FDP)$. Here, we construct methods such that, for any $\gamma$ and $\alpha$, $P\{FDP>\gamma \}\le \alpha$. Based on $p$-values of individual tests, we consider stepdown procedures that control the $FDP$, without imposing dependence assumptions on the joint distribution of the $p$-values. A greatly improved version of a method given in Lehmann and Romano \citer10 is derived and generalized to provide a means by which any sequence of nondecreasing constants can be rescaled to ensure control of the $FDP$. We also provide a stepdown procedure that controls the $FDR$ under a dependence assumption.Comment: Published at http://dx.doi.org/10.1214/074921706000000383 in the IMS Lecture Notes--Monograph Series (http://www.imstat.org/publications/lecnotes.htm) by the Institute of Mathematical Statistics (http://www.imstat.org

AN INVERSE DEMAND APPROACH TO RECREATION FISHING SITE CHOICE AND IMPLIED MARGINAL VALUES

An alternative methodology for determining marginal willingness to pay values for recreational fishing trips is developed based on inverse demand systems and the distance function. Our empirical application uses joint estimation of several species-specific site equations from a recreation fishing data set. Results are compared to a random utility model.Resource /Energy Economics and Policy,

"Measuring Capacity Utilization in OECD Countries: A Cointegration Method"

This paper derives measures of potential output and capacity utilization for a number of OECD countries, using a method based on the cointegration relation between output and the capital stock. The intuitive idea is that economic capacity (potential output) is the aspect of output that co-varies with the capital stock over the long run. We show that this notion can be derived from a simple model that allows for a changing capital-capacity ratio in response to partially exogenous, partially embodied, technical change. Our method provides a simple and general procedure for estimating capacity utilization. It also closely replicates a previously developed census-based measure of U.S. manufacturing capacity-utilization. Of particular interest is that our measures of capacity utilization are very different from those based on aggregate production functions, such as the ones provided by the IMF.

Growth hormone deficiency during young adulthood and the benefits of growth hormone replacement

Until quite recently, the management of children with growth hormone deficiency (GHD) had focussed on the use of recombinant human GH (rhGH) therapy to normalise final adult height. However, research over the past two decades that has demonstrated deficits in bone health and cardiac function, as well as impaired quality of life in adults with childhood-onset GHD (CO-GHD), has questioned this practice. Some of these studies suggested that there may be short-term benefits of rhGH in certain group of adolescents with GHD during transition, although the impact of GHD and replacement during the transition period has not been adequately investigated and its long-term benefits remain unclear. GH therapy remains expensive and well-designed long-term studies are needed to determine the cost effectiveness and clinical benefit of ongoing rhGH during transition and further into adulthood. In the absence of compelling data to justify widespread continuation of rhGH into adult life, there are several questions related to its use that remain unanswered. This paper reviews the effects of growth hormone deficiency on bone health, cardiovascular function, metabolic profile and quality of life during transition and young adulthood