Benthos

Currently, > 4,000 Arctic macro- and megabenthic species are known, representing the majority of Arctic marine faunal diversity. This estimate is expected to increase. • Benthic invertebrates are food to shes, marine mammals, seabirds and humans, and are commercially harvested. • Traditional Knowledge (TK) emphasizes the link between the benthic species and their predators, such as walrus, and their signi cance to culture. • Decadal changes in benthos biodiversity are observed in some well-studied regions, such as the Barents Sea and Chukchi Sea. • Drivers related to climate-change such as warming, ice decline and acidification are affecting the benthic community on a pan-Arctic scale, while drivers such as trawling, river/glacier discharge and invasive species have signficant impact on regional or local scales. • Increasing numbers of species are moving into, or shifting, their distributions in Arctic waters. These species will outcompete, prey on or offer less nutritious value as prey for Arctic species. • Current monitoring efforts have focused on macro- and megabenthic species, but have been confined to the Chukchi Sea and the Barents Sea. Efforts are increasing in waters of Greenland, Iceland, the Canadian Arctic, and in the Norwegian Sea. All other Arctic Marine Areas are lacking long-term benthic monitoring. • As a first step towards an international collaborative monitoring framework, we recommend to develop a time- and cost-effective, long-term and standardized monitoring of megabenthic communities in all Arctic regions with regular annual groundfish assessment surveys. Expanding monitoring on micro-, meio- and macrobenthic groups is encouraged

Self-reported competence, attitude and approach of physicians towards patients with dementia in ambulatory care: Results of a postal survey

<p>Abstract</p> <p>Background</p> <p>Caring for patients with dementia is a demanding task. Little is known as to whether physicians feel competent enough to perform this task or whether a lack of self-perceived competence influences attitudes and professional approach. Even less is known with respect to potential differences between general practitioners (GPs) and specialists. The purpose of this study was to investigate the interrelationship between the self-perceived competence, attitude and professional approach of physicians in ambulatory care in Germany. A further aim was to compare GPs and specialists with regard to differences in these areas.</p> <p>Methods</p> <p>A standardised postal survey was sent to 389 GPs and 239 neurologists and psychiatrists in six metropolitan areas in Germany. The 49-item questionnaire consisted of attitudinal statements to be rated on a Likert-type scale. Return rates were 54 percent for GPs and 40 percent for specialists. Statistical methods used to analyze data included correlation analysis, cluster analysis and ordinal regression analysis.</p> <p>Results</p> <p>No differences were found between GPs and specialists with regard to their general attitude towards caring for patients with dementia. Approximately 15 percent of both disciplines showed a clearly negative attitude. Self-reported competence was strongly associated with general attitude. In particular among GPs, and less so among specialists, a strong positive association was found between self-reported competence, general attitude and professional approach (e.g. early detection, active case finding and cooperation with caregivers). Differences between GPs and specialists were smaller than expected and appear to predominantly reflect task differences within the German health care system.</p> <p>Conclusion</p> <p>Training opportunities which enable in particular GPs to enhance not only their competence but also their general attitude towards dementia care would appear to be beneficial and might carry positive consequences for patients and their caregivers.</p

The ChromaTest, a digital color contrast sensitivity analyzer, for diabetic maculopathy: a pilot study

BACKGROUND: To assess the ability of the Chromatest in investigating diabetic maculopathy. METHOD: Patients with Type 2 diabetes and no concurrent ocular pathology or previous laser photocoagulation were recruited. Visual acuities were assessed followed by colour contrast sensitivity testing of each eye using Chromatest. Dilated fundoscopy with slit lamp biomicroscopy with 78 D lens was then performed to confirm the stage of diabetic retinopathy according to the Early Treatment Diabetic Retinopathy Study. RESULTS: 150 eyes in 150 patients were recruited into this study. 35 eyes with no previous laser photocoagulation were shown to have clinically significant macular oedema (CSMO) and 115 eyes with untreated non-proliferative diabetic retinopathy (NPDR) on fundus biomicroscopy. Statistical significant difference was found between CSMO and NPDR eyes for protan colour contrast threshold (p = 0.01). Statistical significance was found between CSMO and NPDR eyes for tritan colour contrast threshold (p = 0.0002). Sensitivity and specificity for screening of CSMO using pass-fail criterion for age matched TCCT results achieved 71% (95% confidence interval: 53-85%) and 70% (95% confidence interval: 60-78%), respectively. However, threshold levels were derived using the same data set for both training and testing the effectiveness since this was the first study of NPDR using the Chromatest CONCLUSION: The ChromaTest is a simple, cheap, easy to use, and quick test for colour contrast sensitivity. This study did not achieve results to justify use of the Chromatest for screening, but it reinforced the changes seen in tritan colour vision in diabetic retinopathy

The emerging picture of a diverse deep Arctic Ocean seafloor: From habitats to ecosystems

Interest in the deep Arctic Ocean is rapidly increasing from governments, policy makers, industry, researchers, and conservation groups, accentuated by the growing accessibility of this remote region by surface vessel traffic. In this review, our goal is to provide an updated taxonomic inventory of benthic taxa known to occur in the deep Arctic Ocean and relate this inventory to habitat diversity. To achieve this goal, we collected data for Arctic metazoan deep-sea taxa from open-access databases, information facilities, and non-digitised scientific literature, limiting the collection to the area north of 66◦N and below 500 m depth (excluding all shelf seas). Although notable progress has been made in understanding the deep Arctic using novel technologies and infrastructure, this data gathering shows that knowledge of deep-sea benthic Arctic communities remains very limited. Yet, through our compilation of habitat maps, we show that the Arctic contains a high diversity of geomorphological features, including slopes, deep basins, submarine canyons, ridges, and seamounts, as well as chemosynthesis-based and biogenic (biologically engineered) ecosystems. To analyse taxon richness and density, using both morphological and molecular data, we compiled 75,404 faunal records with 2,637 taxa. Phyla with the most records were the Arthropoda (21,405), Annelida (13,763) and Porifera (12,591); phyla with the most documented taxa were the Arthropoda (956), Annelida (566) and Mollusca (351). An overview of the dominant groups inhabiting the different geomorphological features highlights regions in the deep Arctic where data are particularly scarce and increased research efforts are needed, particularly the deep basins of the central Arctic Ocean. This scarcity of deep benthic Arctic biodiversity data creates a bottleneck for developing robust management and conservation measures in a rapidly changing region, leading to a call for international collaboration and shared data to ensure understanding and preservation of these fragile Arctic ecosystems

Unlocking pre-1850 instrumental meteorological records

A global inventory of early instrumental meteorological measurements is compiled that comprises thousands of mostly nondigitized series, pointing to the potential or weather data rescu

The effects of IL-6 on cell adhesion and e-cadherin expression in breast cancer.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldInterleukin 6 (IL-6) is a pleiotropic inflammatory cytokine and its role in cancer is not yet clear. The effects of IL-6 on four breast cancer cell lines and normal mammary epithelium, cultured from milk were tested. Four different patterns of response to IL-6 were found depending on the differentiation status of the cells. In normal mammary epithelial cultures, the effects of IL-6 were mainly growth inhibitory, whereas in MCF-7, IL-6 had growth inhibitory and anti-adhesive effects. In T-47D and ZR-75-1 the anti-adhesive effects were prominent although the growth inhibitory effects were not. These anti-adhesive effects were associated with epithelioid to fibroblastoid morphological changes and a local decrease in E-cadherin expression. In the highly invasive cell line MDA-MB-231, which does not express E-cadherin, no effects of IL-6 were seen. IL-6 levels in the serum of 60 breast cancer patients were found to be increased in 27% (16/60) compared to 2% (1/50) in a control group. Furthermore, it was found that altered E-cadherin expression was seen in 69% of the primary tumours, although no significant association was found between raised serum IL-6 levels and altered E-cadherin expression. Finally IL-6 serum levels did not effect the survival of breast cancer patients. The authors therefore implicate IL-6 as a possible factor important in breast cancer progression and metastasis formation, although the clinical significance of this cytokine in breast cancer patients could not be established

Self reported attentional control with the Attentional Control Scale: factor structure and relationship with symptoms of anxiety and depression.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.The Attentional Control Scale (ACS) is a self-report questionnaire that has been developed to measure individual differences in attentional control. Despite its fairly widespread use, little is known about the psychometric properties of the scale in adult samples. In the present study, factor structure of the ACS and its relationship with symptoms of anxiety and depression was investigated in a total sample of 728 Icelandic university students. Exploratory factor analysis in sample 1 (n=361), yielded two factors, labeled focusing and shifting. Confirmatory factor analysis in sample 2 (n=367) showed a reasonable fit of this two factor model. The two factors correlated strongly (0.73). The two subscales showed different predictive validity in a set of hierarchical regression analyses where the focusing subscale made a significant prediction of anxiety scores when depression scores were controlled for, and the shifting subscale significant prediction of depression scores when anxiety scores were controlled for. These findings are discussed in relation to previous studies on attentional and executive control in anxiety and depression

Altered expression of E-cadherin in breast cancer patterns, mechanisms and clinical significance

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldReduced cell adhesion brought about by altered surface expression of E-cadherin has been implicated in invasive and metastatic malignant growth. We investigated the patterns of immunohistochemical E-cadherin expression in 120 breast carcinomas. Furthermore, we analysed DNA from the same samples for loss of heterozygosity (LOH) using three separate microsatellite markers on chromosome 16q22.1. Finally, the clinical outcome was ascertained for 108 patients. 19% (18/97) of infiltrating ductal carcinomas showed complete loss of E-cadherin expression compared with 64% (9/14) of infiltrating lobular carcinomas. LOH was detected in 46% (24/52) of infiltrating ductal carcinomas and 89% (8/9) of infiltrating lobular carcinomas. In the infiltrating lobular carcinomas, LOH was associated with complete loss of cell membrane expression of E-cadherin, although a cytoplasmic expression pattern was evident. In contrast, this association was not seen in the infiltrating ductal carcinomas. In a multivariate analysis, loss of E-cadherin expression was shown to be a significant independent risk factor for a poorer disease-free survival (P=0.019), in particular in the node-negative subset of patients (P=0.029). Significance was also approached for breast cancer corrected survival (P=0.056). We conclude that different mechanisms are involved in the altered E-cadherin expression seen in different subtypes of breast carcinomas. Furthermore, we implicate loss of E-cadherin, regardless of the genetic causes, as an independent prognostic marker for disease recurrence, especially in node-negative breast cancer patients, irrespective of the histological type