Tachyon Field Quantization and Hawking Radiation

We quantize the tachyon field in a static two dimensional dilaton gravity black hole background,and we calculate the Hawking radiation rate. We find that the thermal radiation flux, due to the tachyon field, is larger than the conformal matter one. We also find that massive scalar fields which do not couple to the dilaton, do not give any contribution to the thermal radiation, up to terms quadratic in the scalar curvature.Comment: 13 pages, Latex file, 1 figure available upon reques

Codon 89 polymorphism in the human 5 α -reductase gene in primary breast cancer

The enzyme human steroid 5-α reductase type II (SRD5A2) and androgen receptor (AR) are critical mediators of androgen action, suggesting a potential role in hormonally related cancers. The SRD5A2 gene harbours two frequent polymorphic sites, one in the coding region, at codon 89 of exon 1, where valine is substituted by leucine (V89L) and the other in the 3′ untranslated region (3′ UTR) where a variable number of dinucleotide TA repeat lengths exists. The V89L polymorphism is known to alter the activity of this enzyme. In the present study we examined 144 sporadic breast tumours from Italian patients for the V89L and TA polymorphisms by sequence and fragment analysis, respectively. Tumour extract prostate specific antigen (PSA) concentration as well as a number of well-established clinical and pathological parameters were evaluated. The results show that 53% of the tumours were homozygous for VV alleles, 37% were heterozygous for VL alleles and 10% were homozygous for LL alleles. TA(0) repeats were found in tumours with VV, LL and VL genotypes. TA(9) repeats were only found in VV homozygotes and were totally absent from either LL homozygotes or VL heterozygotes. PSA expression was significantly elevated in tumours with VV genotype. The presence of LL alleles in breast tumours is associated with earlier onset and shorter disease-free (RR = 2.65;P = 0.013) and overall survival (RR = 3.06;P = 0.014) rates. The VV genotype is associated with a more favourable prognosis. Our study suggests that the polymorphism in codon 89 of exon 1 of the human 5α-reductase gene is related with TA repeat genotypes, PSA expression and breast cancer prognosis. More specifically, we found that the LL genotype is also associated with earlier onset and more aggressive forms of breast cancer. Long-term-outcome studies are needed to investigate the relevance of this polymorphism to breast cancer susceptibility. © 2001 Cancer Research Campaign http://www.bjcancer.co

Activation and enzymatic characterization of recombinant human kallikrein 8

Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl endopeptidase-conjugated beads. Amino-terminal sequencing of the activated enzyme demonstrated the cleavage of a 9-aa propeptide from the pro-enzyme. The substrate specificity of activated hK8 was characterized using synthetic fluorescent substrates. hK8 showed trypsin-like specificity, as predicted from sequence analysis and enzymatic characterization of the mouse ortholog. All synthetic substrates tested containing either arginine or lysine at P1 position were cleaved by hK8. The highest k cat/K m value of 20×103M-1 s-1 was observed with Boc-Val-Pro-Arg-7-amido-4-methylcoumarin. The activity of hK8 was inhibited by antipain, chymostatin, and leupeptin. The concentration for 50% inhibition by the best inhibitor, antipain, was 0.46μM. The effect of different metal ions on the enzyme activity was analyzed. Whereas Na+ had no effect on hK8 activity, Ni2+ and Zn2+ decreased the activity and Ca2+, Mg2+, and K+ had a stimulatory effect. Ca2+ was the best activator, with an optimal concentration of approximately 10μ

The issue of Dark Energy in String Theory

Recent astrophysical observations, pertaining to either high-redshift supernovae or cosmic microwave background temperature fluctuations, as those measured recently by the WMAP satellite, provide us with data of unprecedented accuracy, pointing towards two (related) facts: (i) our Universe is accelerated at present, and (ii) more than 70 % of its energy content consists of an unknown substance, termed dark energy, which is believed responsible for its current acceleration. Both of these facts are a challenge to String theory. In this review I outline briefly the challenges, the problems and possible avenues for research towards a resolution of the Dark Energy issue in string theory.Comment: Based on Invited lecture at the ``Third Aegean Summer School on: The Invisible Universe: Dark matter and Dark energy'', Karfas, Chios Island (Greece) September 26-October 1 200

Composite Supersymmetries in low-dimensional systems

Starting from a N=1 scalar supermultiplet in 2+1 dimensions, we demonstrate explicitly the appearance of induced N=1 vector and scalar supermultiplets of composite operators made out of the fundamental supersymmetric constituents. We discuss an extension to a N=2 superalgebra with central extension, due to the existence of topological currents in 2+1 dimensions. As a specific model we consider a supersymmetric $CP^1$ $\sigma$-model as the constituent theory, and discuss the relevance of these results for an effective description of the infrared dynamics of planar high-temperature superconducting condensed matter models with quasiparticle excitations near nodal points of their Fermi surface.Comment: 20 pages Latex, no figure

Fully Reversible Contrast-Induced Encephalopathy Mimicking Stroke after Flow Diverter Treatment of Carotid Cave Aneurysm

Contrast-induced encephalopathy (CIE) is a rare complication of coronary and neurointerventional procedures. The condition is believed to arise from endothelial damage secondary to exposure to iodinated contrast media. A wide spectrum of clinical manifestations has been reported including seizures, cortical blindness, and focal neurological deficits. This report details the case of fully reversible CIE mimicking severe anterior circulation stroke in a 55-year-old female following elective endovascular treatment with a flow diverter of a carotid cave aneurysm. The patient was managed conservatively with intravenous hydration and steroids and showed an excellent prognosis with supportive management