Dr.Bokeh: DiffeRentiable Occlusion-aware Bokeh Rendering

Bokeh is widely used in photography to draw attention to the subject while effectively isolating distractions in the background. Computational methods simulate bokeh effects without relying on a physical camera lens. However, in the realm of digital bokeh synthesis, the two main challenges for bokeh synthesis are color bleeding and partial occlusion at object boundaries. Our primary goal is to overcome these two major challenges using physics principles that define bokeh formation. To achieve this, we propose a novel and accurate filtering-based bokeh rendering equation and a physically-based occlusion-aware bokeh renderer, dubbed Dr.Bokeh, which addresses the aforementioned challenges during the rendering stage without the need of post-processing or data-driven approaches. Our rendering algorithm first preprocesses the input RGBD to obtain a layered scene representation. Dr.Bokeh then takes the layered representation and user-defined lens parameters to render photo-realistic lens blur. By softening non-differentiable operations, we make Dr.Bokeh differentiable such that it can be plugged into a machine-learning framework. We perform quantitative and qualitative evaluations on synthetic and real-world images to validate the effectiveness of the rendering quality and the differentiability of our method. We show Dr.Bokeh not only outperforms state-of-the-art bokeh rendering algorithms in terms of photo-realism but also improves the depth quality from depth-from-defocus

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion injury (MIRI) is a common pathological and physiological phenomenon. Tetramethylpyrazine is the extract of the traditional Chinese medicine Chuanxiong, which can exert protective effects on MIRI in multiple ways. This paper reviewed the current research progress and evidence about the cardiovascular effects of tetramethylpyrazine, which included protecting mitochondria and improving energy metabolism, scavenging oxygen free radicals (OFRs) to inhibit lipid peroxidation, attenuating calcium (Ca2+) overload and maintaining Ca2+ homeostasis in cells, inhibiting apoptosis and protecting myocardial cells, interfering with the inflammatory reaction and mitigating cell injury, interfering with cell signaling pathways, and improving function of endothelial cells and protecting myocardial cells. However, further rigorously designed randomized controlled trials are warranted

Case report: Catastrophic event: neonatal gastric perforation and complication of capillary leak syndrome

Neonatal gastric perforation (NGP) is a rare, but life-threatening condition that can lead to serious conditions, such as capillary leak syndrome (CLS). Here, we present the case of a preterm male infant with NGP complicated by CLS after stomach repair. The patient was born at 33 2/7 weeks, weighed 1,770 g, and was diagnosed with respiratory distress syndrome. On the fourth day of life, the patient presented with distention and an unstable cardiovascular system. Routine blood tests revealed a white blood cell count of 2.4 × 109/L. Chest and abdominal radiography revealed a pneumoperitoneum, suggesting a gastrointestinal perforation. The patient was urgently transferred to a tertiary hospital for exploratory laparotomy, where a 2 cm diameter perforation was discovered in the stomach wall and subsequently repaired. Pathological findings indicated the absence of a muscular layer in the stomach wall. The patient unexpectedly developed CLS postoperatively, leading to multiorgan dysfunction and eventual death. The underlying pathological mechanism of NGP-induced CLS may be related to severe chemical peritonitis, sepsis, endothelial glycocalyx dysfunction, enhanced systemic inflammation, and translocation of the gut microbiota, causing endothelial hyperpermeability. Notablely, abdominal surgery itself can be a significant triggering factor for CLS occurrence. Complications of NGP and CLS are extremely dangerous. Investigating the mechanism by which NGP triggers CLS could potentially improve the prognosis. Conservative treatment for pneumoperitoneum secondary to gastric perforation may be a reasonable option, especially when the condition of the patient is unstable

Novel core/void/shell composite phase change materials for high temperature thermal energy storage

Abstract(#br)Metallic solid-liquid phase change materials (SLPCMs) are crucial for the thermal energy storage technology of various industrial systems. However, the encapsulation of metallic SLPCMs is still technically difficult. In this pursuit, the present research envisaged the development of a novel technology to successfully prepare the core(=Al-Si/Bi)/void/shell(=Al 2 O 3 ) composite SLPCMs by using Al/Bi immiscible alloy powders as starting material and tetraethoxysilane as SiO 2 source. The Al-Si alloy and Al 2 O 3 shell were in-situ synthesized by the displacement reaction between SiO 2 and molten Al. Interestingly, most of the Bi distributed in the shell of Al/Bi immiscible alloy powders could not only improve the activity of alloy powders and promote the formation of precursor shell, but also be recycled by evaporation to form the void layer during the calcination process of composite SLPCMs. The produced void layer provided a space buffer to alleviate the volume expansion of the core SLPCM, and thereby improving the thermal cycling stability of the prepared composite SLPCMs. The thermal cycling test results showed that after 300 thermal cycles, the melting latent heat reduction of the core(=Al-Si/Bi)/void/shell(=Al 2 O 3 ) composite SLPCMs (24.3-31.7J/g) was much less than that of the core(=Al-Si)/shell(=Al 2 O 3 ) composite SLPCM (58.1J/g). Moreover, the prepared Al-Si/Bi/Al 2 O 3 exhibited an adjustable melting temperature (571.9℃ to 631.9℃) and average particle diameter (39.3μm to 112.6μm), relatively high thermal conductivity [2.068W(mK) -1 to 2.966W(mK) -1 ], and excellent thermal energy storage capacity (209.5J/g to 278.2J/g). Thus, the prepared Al-Si/Bi/Al 2 O 3 composite SLPCMs are potential thermal energy storage materials, which can be used to improve the energy efficiency of various industrial systems

A strategy for designing microencapsulated composite phase change thermal storage materials with tunable melting temperature

Abstract(#br)Thermal energy storage technology with high temperature phase change materials (PCMs) plays an increasingly important role in the concentrated solar power plants and industrial waste heat recovery systems. In this study, a novel displacement reaction between tetraethoxysilane as SiO 2 source and molten raw Al powder was purposed to successfully prepare Al-Si/Al 2 O 3 high temperature composite PCMs. Interestingly, by proposed synthetic methodology, we not only achieved the in-situ synthesis of Al-Si alloy PCM and Al 2 O 3 shell, but also realized the controllability of Al-Si alloy composition and Al 2 O 3 shell layer thickness. Our results indicated that the melting temperature of the prepared composite PCMs depended on the composition of Al-Si alloy, and could be designed within a certain temperature range (from 574.0 °C to 641.4 °C), instead of a particular temperature point. The melting temperature adjustability of the prepared composite PCMs provided an additional flexibility in different working temperature conditions. Moreover, the prepared composite PCMs exhibited a relatively high thermal storage capacity (248.6 J/g to 331.0 J/g), good thermal stability, excellent repeatable utilization property and certain shell layer self-repairing ability in the working temperature range. Therefore, the prepared composite PCMs can prove to be promising thermal energy storage materials for improving the energy efficiency in various systems under different working temperature conditions

Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline

Background: A new, effective anti-tuberculosis (TB) regimen containing bedaquiline (BDQ) and pyrifazimine (TBI-166) has been recommended for a phase IIb clinical trial. Preclinical drug–drug interaction (DDI) studies of the combination of BDQ and TBI-166 have been designed to support future clinical trials. In this study, we investigated whether a DDI between BDQ and TBI-166 affects the pharmacokinetics of BDQ.Methods: We performed in vitro quantification of the fractional contributions of the fraction of drug metabolism by individual CYP enzymes (fm) of BDQ and the inhibition potency of key metabolic pathways of TBI-166. Furthermore, we conducted an in vivo steady-state pharmacokinetics study in a murine TB model and healthy BALB/c mice.Results: The in vitro fm value indicated that the CYP3A4 pathway contributed more than 75% to BDQ metabolism to N-desmethyl-bedaquiline (M2), and TBI-166 was a moderate (IC50 2.65 µM) potential CYP3A4 inhibitor. Coadministration of BDQ and TBI-166 greatly reduced exposure to metabolite M2 (AUC0-t 76310 vs 115704 h ng/mL, 66% of BDQ alone), whereas the exposure to BDQ and TBI-166 did not changed. The same trend was observed both in healthy and TB model mice. The plasma concentration of M2 decreased significantly after coadministration of BDQ and TBI-166 and decreased further during treatment in the TB model.Conclusions: In conclusion, our results showed that the combination of BDQ and TBI-166 significantly reduced exposure to the toxic metabolite M2 by inhibiting the activity of the CYP3A4 pathway. The potential safety and efficacy benefits demonstrated by the TB treatment highly suggest that coadministration of BDQ and TBI-166 should be studied further

Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder

BackgroundThe systemic immune-inflammation index (SII), system inflammation response index (SIRI), neutrophil/high-density lipoprotein (HDL) ratio (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL ratio (MHR), and platelet/HDL ratio (PHR) have been recently investigated as new markers for inflammation. The purpose of this research is to use large-scale clinical data to discuss and compare the predictive ability of the SII, SIRI, NHR, LHR, MHR, and PHR in patients with schizophrenia (SCZ) and bipolar disorder (BD), to investigate potential biomarkers.Materials and methodsIn this retrospective, naturalistic, cross-sectional study, we collected the hematological parameter data of 13,329 patients with SCZ, 4,061 patients with BD manic episodes (BD-M), and 1,944 patients with BD depressive episodes (BD-D), and 5,810 healthy subjects served as the healthy control (HC) group. The differences in the SII, SIRI, NHR, LHR, MHR, and PHR were analyzed, and a receiver operating characteristic (ROC) curve was used to analyze the diagnostic potential of these parameters.ResultsCompared with the HC group, the values of the SII, SIRI, NHR, LHR, MHR, and PHR and the levels of neutrophils, monocytes, and triglycerides (TG) were higher in SCZ and BD groups, and levels of platelets, cholesterol (CHO), HDL, low-density lipoprotein (LDL), and apoprotein B (Apo B) were lower in SCZ and BD groups. Compared to the BD group, the values of the SIRI, lymphocytes, monocytes, and HDL were lower and the values of the SII, NHR, PHR, and platelet were higher in the SCZ group. In contrast to the BD-D group, the values of the SII; SIRI; NHR; and MHR; and levels of neutrophils, monocytes, and platelets were higher in the BD-M group, and the levels of CHO, TG, LDL, and Apo B were lower in the BD-M group. The MHR and NHR were predictors for differentiating the SCZ group from the HC group; the SIRI, NHR, and MHR were predictors for differentiating the BD-M group from the HC group; and the MHR was a predictor for differentiating the BD-D group from the HC group. The combination model of the indicators improved diagnostic effectiveness.ConclusionOur study highlights the role of systemic inflammation in the pathophysiology of SCZ, BD-M, and BD-D, the association between inflammation and lipid metabolism, and these inflammation and lipid metabolism indicators showed different variation patterns in SCZ, BD-D, and BD-M

A study of CP violation in B-+/- -> DK +/- and B-+/- -> D pi(+/-) decays with D -> (KSK +/-)-K-0 pi(-/+) final states

A first study of CP violation in the decay modes $B^\pm\to [K^0_{\rm S} K^\pm \pi^\mp]_D h^\pm$ and $B^\pm\to [K^0_{\rm S} K^\mp \pi^\pm]_D h^\pm$, where $h$ labels a $K$ or $\pi$ meson and $D$ labels a $D^0$ or $\overline{D}^0$ meson, is performed. The analysis uses the LHCb data set collected in $pp$ collisions, corresponding to an integrated luminosity of 3 fb$^{-1}$. The analysis is sensitive to the CP-violating CKM phase $\gamma$ through seven observables: one charge asymmetry in each of the four modes and three ratios of the charge-integrated yields. The results are consistent with measurements of $\gamma$ using other decay modes