Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options

Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was granted approval for treatment of moderate-to-severe AD. Biologics targeting IgE/Th2 pathways may have its role in patients with overlapping AD and asthma. Psychological distress can exacerbate symptoms and is associated with increased severity of AD. Environmental triggers, such as, allergens can be addressed in selected cases with allergic immunotherapy. In this paper, we discuss AD treatment and propose a new step-by-step approach aiming at maintaining disease control and improving quality of life.info:eu-repo/semantics/publishedVersio

A New Galactic Wolf-Rayet Star in Centaurus

In this work I communicate the detection of a new Galactic Wolf-Rayet star (WR60a) in Centaurus. The H- and K-band spectra of WR60a, show strong carbon near-infrared emission lines, characteristic of Wolf-Rayet stars of the WC5-7 sub-type. Adopting mean absolute magnitude M$_K$ and mean intrinsic ($J-K_S$) and ($H-K_S$) colours, it was found that WR60a suffer a mean visual extinction of 3.8$\pm$1.3 magnitudes, being located at a probable heliocentric distance of 5.2$\pm$0.8 Kpc, which for the related Galactic longitude (l=312) puts this star probably in the Carina-Sagittarius arm at about 5.9 kpc from the Galactic center. I searched for clusters in the vicinity of WR60a, and in principle found no previously known clusters in a search radius region of several tens arc-minutes. The detection of a well isolated WR star induced us to seek for some still unknown cluster, somewhere in the vicinity of WR60a. From inspection of 5.8$\mu$m and 8.0$\mu$m Spitzer/IRAC GLIMPSE images of the region around the new WR star, it was found strong mid-infrared extended emission at about 13.5 arcmin south-west of WR60a. The study of the the H-K$_S$ colour distribution of point sources associated with the extended emission, reveals the presence of a new Galactic cluster candidate probably formed by at least 85 stars.Comment: 5 pages, 2 tables and 4 figures. Figure 4 is in low-resolution mode. The published on-line version of the paper can be obtained at http://www.isrn.com/journals/astro/2011/632850