VIDEO: Session 3: Mapping a New Course, Panel E: Who Should Be at the Table, and What Should They Be Talking About?

VIDEO: 8:30 a.m. - 10:05 a.m. SESSION 3: Mapping a New Course Panel E: Who Should Be at the Table, and What Should They be Talking About? Provocateur: Joe Feller, Professor of Law, Arizona State University Speaker: Robert Adler, James I. Farr Chair in Law, University of Utah, S.J. Quinney College of Law Commentator: Jim Lochhead, CEO/Manager, Denver Wate

VIDEO: Session 3: Mapping a New Course, Panel E: Who Should Be at the Table, and What Should They Be Talking About?

VIDEO: 8:30 a.m. - 10:05 a.m. SESSION 3: Mapping a New Course Panel E: Who Should Be at the Table, and What Should They be Talking About? Provocateur: Joe Feller, Professor of Law, Arizona State University Speaker: Robert Adler, James I. Farr Chair in Law, University of Utah, S.J. Quinney College of Law Commentator: Jim Lochhead, CEO/Manager, Denver Wate

VIDEO: Session I, Part 2: The Decision and Its Consequences: Then and Now

VIDEO: 11:15 a.m. - 12:00 p.m. SESSION I, PART 2: The Decision and Its Consequences: Then and Now Respondents: Sandy Fabritz-Whitney, Director, Arizona Department of Water Resources Jeff Kightlinger, General Manager, Metropolitan Water District of Southern California Jim Lochhead, CEO/Manager, Denver Wate

VIDEO: Session 2: Practicing Sustainability in Natural Resource Industries

This session will address the growing attention to sustainability in traditional natural resources industries and the increasing recognition of the considerable challenges facing efforts to operationalize this broad concept in the context of resource extraction and development. Specific topics will include the changing role of chief sustainability officers, the trends in industry compliance efforts, and the emerging rating systems for sustainability performance by companies. It will also discuss the role of different stakeholders and the challenges of new models of governance (that is, different from traditional command-and-control regulation) that enable the sustainability norm to be internalized by industry participants and guided by emerging collaborative governance initiatives. VIDEO: 11:15 p.m. - 12:45 p.m. SESSION 2: Practicing Sustainability in Natural Resource Industries Moderator: Phil Weiser, Dean, University of Colorado Law School Speakers: Stan Dempsey, Chairman, Royal Gold Heidi McIntosh, Managing Attorney, EarthJustice Rocky Mountain Office Jim Lochhead, CEO/Manager, Denver Water Markus Funk, Co-Chair, Social Responsibility and Supply Chain Practices, Perkins Coie Gary Libecap, Professor, Corporate Environmental Management, University of California Santa Barbar

VIDEO: Session 3: Mapping a New Course, Panel G: Concluding Thoughts . . . and Looking Ahead

VIDEO: 1:30 p.m. - 3:30 p.m. SESSION 3: Mapping a New Course Panel G: Concluding Thoughts . . . and Looking Ahead Moderator: Guy Martin, Partner, Perkins Coie, Washington, D.C. Panelists: Don Ostler, Upper Colorado River Commission Terry Fulp, Deputy Regional Director for the Lower Colorado Region, Bureau of Reclamation Kimery Wiltshire, CEO and President, Carpe Diem West Taylor Hawes, Colorado River Program Director, The Nature Conservancy Jim Lochhead, CEO/Manager, Denver Water Lynn Scarlett, former Deputy Secretary of the Interio

VIDEO: Session IV: The Big Picture

VIDEO: SESSION IV: The Big Picture 1:30 p.m. - 2:00 p.m. Restoring the Health of the River: Jack Schmidt, Chief, USGS Grand Canyon Monitoring and Research Center 2:00 p.m. - 2:30 p.m. Reckoning Arizona v. California with the Colorado River Compact: Jason Robison, Professor, University of Wyoming 2:30 p.m. - 4:00 p.m. Tying it All Together: Final Observations: Eric Kuhn, General Manager, Colorado River Water Conservation District Tanya Trujillo, Executive Director, Colorado River Board of California Pat Mulroy, General Manager, Southern Nevada Water Authority Jim Lochhead, CEO/Manager, Denver Water Sandy Fabritz-Whitney, Director, Arizona Department of Water Resource

VIDEO: Session IV: The Big Picture

VIDEO: SESSION IV: The Big Picture 1:30 p.m. - 2:00 p.m. Restoring the Health of the River: Jack Schmidt, Chief, USGS Grand Canyon Monitoring and Research Center 2:00 p.m. - 2:30 p.m. Reckoning Arizona v. California with the Colorado River Compact: Jason Robison, Professor, University of Wyoming 2:30 p.m. - 4:00 p.m. Tying it All Together: Final Observations: Eric Kuhn, General Manager, Colorado River Water Conservation District Tanya Trujillo, Executive Director, Colorado River Board of California Pat Mulroy, General Manager, Southern Nevada Water Authority Jim Lochhead, CEO/Manager, Denver Water Sandy Fabritz-Whitney, Director, Arizona Department of Water Resource

Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase

cAMP-dependent protein kinase A (PKA), ubiquitously expressed in mammalian cells, regulates a plethora of cellular processes through its ability to phosphorylate many protein substrates, including transcription factors, ion channels, apoptotic proteins, transporters, and metabolic enzymes. The PKA catalytic subunit has two phosphorylation sites, a well-studied site in the activation loop (Thr197) and another site in the C-terminal tail (Ser338) for which the role of phosphorylation is unknown. We show here, using in vitro studies and experiments with S49 lymphoma cells, that cis-autophosphorylation of Ser338 occurs cotranslationally, when PKA is associated with ribosomes and precedes posttranslational phosphorylation of the activation loop Thr197. Ser338 phoshorylation is not required for PKA activity or formation of the holoenzyme complex; however, it is critical for processing and maturation of PKA, and it is a prerequisite for phosphorylation of Thr197. After Thr197 and Ser338 are phosphorylated, both sites are remarkably resistant to phosphatases. Phosphatase resistance of the activation loop, a unique feature of both PKA and PKG, reflects the distinct way that signal transduction dynamics are controlled by cyclic nucleotide-dependent PKs