Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series

OBJECTIVE: To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series. Design: Randomised, double blind, placebo controlled, parallel group, multicentre study. SETTING: Four general practices and a hospital ear, nose, and throat outpatient department. PARTICIPANTS: 51 patients with perennial allergic rhinitis. Intervention: Random assignment to an oral 30c homoeopathic preparation of principal inhalant allergen or to placebo. MAIN OUTCOME MEASURES: Changes from baseline in nasal inspiratory peak flow and symptom visual analogue scale score over third and fourth weeks after randomisation. RESULTS: Fifty patients completed the study. The homoeopathy group had a significant objective improvement in nasal airflow compared with the placebo group (mean difference 19.8 l/min, 95% confidence interval 10.4 to 29.1, P=0.0001). Both groups reported improvement in symptoms, with patients taking homoeopathy reporting more improvement in all but one of the centres, which had more patients with aggravations. On average no significant difference between the groups was seen on visual analogue scale scores. Initial aggravations of rhinitis symptoms were more common with homoeopathy than placebo (7 (30%) v 2 (7%), P=0.04). Addition of these results to those of three previous trials (n=253) showed a mean symptom reduction on visual analogue scores of 28% (10.9 mm) for homoeopathy compared with 3% (1.1 mm) for placebo (95% confidence interval 4.2 to 15.4, P=0.0007). CONCLUSION: The objective results reinforce earlier evidence that homoeopathic dilutions differ from placebo

Plasma Physics

Contains research objectives and reports on three research projects.United States Atomic Energy Commission (Contract AT(30-1)-1842

Secure Proximity-Based Identity Pairing using an Untrusted Signalling Service

New protocols such as WebRTC promise seamless in-browser peer-to-peer communications that in theory remove the need for third-party services. In practice, widespread use of Firewalls, NATS and dynamic IP addresses mean that overlay addressing or use of some fixed rendezvous point is still needed. In this paper we describe a proximity-based pairing scheme that uses a signalling service to minimise the trust requirements on the third party, achieving anonymity and avoiding the need for PKI, while still requiring only a simple asymmetric pairing protocol

Plasma Physics

Contains reports on five research projects.United States Atomic Energy Commission (Contract AT(30-1)-1842)Project MACAdvanced Research Agency, Department of Defense, under Office of Naval Research Contract Nonr-4102(01

Plasma Physics

Contains reports on seven research projects.United States Atomic Energy Commission under Contract AT(30-1)-1842Joint Services Electronics Programs (U.S. Army, U.S. Navy, and U.S. Air Force) under Contract DA 28-043-AMC-02536(E

Plasma Physics

Contains reports on eight research projects.U. S. Atomic Energy Commission (Contract AT(30-1)-1842)U. S. Navy (Office of Naval Research) under Contract Nonr-1841(42

Pico in the Wild: Replacing Passwords, One Site at a Time

Passwords are a burden on the user, especially nowadays with an increasing number of accounts and a proliferation of different devices. Pico is a token-based login method that does not ask users to remember any secrets, nor require keyboard entry of one-time passwords. We wish to evaluate its claim of being simultaneously more usable and more secure than passwords, whilst testing its support for frictionless deployment to web-based services. Our main aim is to collect actionable intelligence on how to improve it. In our study, we teamed up with an Alexa Top 500 website, Gyazo, to offer this alternative login mechanism to users intent on performing a real task of image sharing. We focused on the ecological validity of the trial, and gained knowledge both through the challenges of the trial and the results generated. Users appreciated the ability to avoid password entry but the overall benefit was mitigated by the existing measures put in place by Gyazo to minimise the number of times users are presented with a password entry box. Our main finding is that providing enough benefit requires a solution that applies across sites, rather than focusing on authentication for a single site in isolation.We would also like to thank the European Research Council (ERC) for funding this research through grant StG 307224 (Pico) and the Engineering and Physical Sciences Research Council (EPSRC) through grant EP/M019055/1

Combined application of nitrogen and phosphorus to enhance nitrogen use efficiency and close the wheat yield gap on varying soils in semi‐arid conditions

A primary driver of the wheat yield gap in Australia and globally is the supply of nitrogen (N) and options to increase N use efficiency (NUE) are fundamental to closure of the yield gap. Co‐application of N with phosphorus (P) is suggested as an avenue to increase fertiliser NUE, and inputs of N and P fertiliser are key variable costs in low rainfall cereal crops. Within field variability in the response to nutrients due to soil and season offers a further opportunity to refine inputs for increased efficiency. The response of wheat to N fertiliser input (0, 10, 20, 40 and 80 kg N ha‐1) under four levels of P fertiliser (0, 5, 10 and 20 kg P ha−1) was measured on three key low rainfall cropping soils (dune, mid‐slope and swale) across a dune‐swale system in a low rainfall semi‐arid environment in South Australia, for three successive cropping seasons. Wheat on sandy soils produced significant and linear yield and protein responses across all three seasons, while wheat on a clay loam only produced a yield response in a high rainfall season. Responses to P fertiliser were measured on the sandy soils but more variable in nature and a consistent effect of increased P nutrition leading to increased NUE was not measured

Deploying authentication in the wild: Towards greater ecological validity in security usability studies

Abstract Pico is a token-based login method that claims to be simultaneously more usable and more secure than passwords. It does not ask users to remember any secrets, nor to type one-time passwords. We evaluate Pico’s claim with two deployments and user studies, one on a web-based service and another within an organization. Our main aim is to collect actionable intelligence on how to improve the usability and deployability of Pico. In our first study we team up with an established website, Gyazo, to offer this alternative login mechanism to users intent on performing a real task of image sharing. From the lessons of this first study, we retarget Pico’s focus from replacing web passwords to replacing desktop login passwords; and thus in our second study we engage with a government organization, Innovate UK, to offer employees the ability to lock and unlock their computer automatically based on proximity. We focus particularly on the ecological validity of the trials and we thereby gain valuable insights into the viability of Pico, not only through the actual responses from the participants but also through the many practical challenges we had to face and overcome. Reflecting on the bigger picture, from our experience we believe the security usability community would greatly benefit from pushing towards greater ecological validity in published work, despite the considerable difficulties and costs involved.This work was supported by the European Research Council (ERC) [StG 307224, Pico, to FMS] and the extended visits of Gyazo inventor and CTO Masui to Cambridge were supported by the Engineering and Physical Sciences Research Council (EPSRC) [EP/M019055/1, Future authentication systems, to FMS]

The pharmaceutical use of permethrin: Sources and behavior during municipal sewage treatment

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Springer Science+Business Media, LLC.Permethrin entered use in the 1970s as an insecticide in a wide range of applications, including agriculture, horticultural, and forestry, and has since been restricted. In the 21st century, the presence of permethrin in the aquatic environment has been attributed to its use as a human and veterinary pharmaceutical, in particular as a pedeculicide, in addition to other uses, such as a moth-proofing agent. However, as a consequence of its toxicity to fish, sources of permethrin and its fate and behavior during wastewater treatment are topics of concern. This study has established that high overall removal of permethrin (approximately 90%) was achieved during wastewater treatment and that this was strongly dependent on the extent of biological degradation in secondary treatment, with more limited subsequent removal in tertiary treatment processes. Sources of permethrin in the catchment matched well with measured values in crude sewage and indicated that domestic use accounted for more than half of the load to the treatment works. However, removal may not be consistent enough to achieve the environmental quality standards now being derived in many countries even where tertiary treatment processes are applied.United Utilities PL