Translation and validation of the Chinese (HK) version of GOHAI

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Functional occluding units and satisfaction with dental condition in elderly

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Development of an oral health expectation index for elderly

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A regimen of systematic periodontal care after removal of impacted mandibular third molars manages periodontal pockets associated with the mandibular second molars

Aim: This randomized, single-blinded control trial investigated the local effects of periodontal care on the mandibular second molar delivered during and after impacted third molar surgical extraction. Method: Thirty subjects (50% male, 32.1 ± 7.8 years) out of 35 enrolled, with a mesio-angular impacted mandibular third molar, having probing pocket depth (PPD) > 5 mm at adjacent second molar distal, and crestal radio-lucency between the two teeth, completed the study. Oral hygiene instruction, scaling and caries stabilization were performed before surgery. Controls (n = 16) had their third molar extracted followed by standard socket debridement. Test group subjects (n = 14) received the same treatment, except that before wound closure the operator was informed of the group allocation and ultrasonic root debridement on the second molar was performed, followed by a three-visit plaque control programme. Results: Six months post-extraction, statistically significantly (p < 0.007) better plaque control and shallower probing depths were observed at test second molars' distal (%plaque = 21; PPD = 3.2 ± 1.2 mm) than at control second molars (%plaque = 88; PPD = 5.2 ± 0.7 mm). Conclusions: The periodontal interventions investigated prevented residual pockets on periodontally involved second molars 6 months after ipsilateral impacted mandibular third molar removal. Copyright © Blackwell Munksgaard 2005.postprin

Residual periodontal defects distal to the mandibular second molar 6-36 months after impacted third molar extraction: A retrospective cross-sectional study of young adults

Aim: This retrospective study investigated the periodontal conditions distal to mandibular second molars 6-36 months after routine surgical extraction of adjacent impacted third molars. Method: Subjects were randomly selected by systematic sampling from computer records of 3211 surgical mandibular third molar extractions in the Hong Kong dental teaching hospital. Records and pre-extraction radiographs of the selected cases were retrieved. Selected subjects (n = 283) were invited for an interview followed by a clinical examination. Community Periodontal Index (CPI) protocol was used for the assessment of the general periodontal status (excluding the mandibular second molar of interest, i.e. the subject tooth) followed by a detailed periodontal examination of the subject tooth. Results: In all, 158 subjects, aged 29 ± 7 years, were examined with only 6% (nine subjects) having a highest CPI score of 4 (excluding the subject tooth), but local periodontal defects were prevalent at the distal surface of subject mandibular second molars: mean probing pocket depth (PPD) was 5.4 ± 1.9 mm with 67% (106 subjects) exhibiting PPD ≥ 5 mm and 23% (36 subjects) exhibiting PPD ≥ 7 mm; mean recession was 0.8 ± 1.0 mm; bleeding on probing 96% and suppuration on probing 5%. Multiple linear regression analysis was used to analyse the effects of 12 independent variables on the PPD at the distal surface of the involved mandibular second molar. Three possible risk indicators (P < 0.001, R 2 = 0.27) associated with localised increased PPD at the distal surface of the mandibular second molars were identified: 1) third molar 'mesio-angular' impaction; 2) pre-extraction crestal radiolucency and 3) inadequate post-extraction local plaque control. Conclusion: The results suggest that periodontal breakdown initiated and established on the distal surface of a mandibular second molar in the vicinity of a 'mesio-angular' impacted third molar evidenced by pre-extraction crestal radiolucency in association with inadequate plaque control after extraction can predispose to a persistent localised periodontal problem. © Blackwell Munksgaard, 2002.postprin

Prevention of periodontal pockets on mandibular second molars after third molar removal

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Astragalus membranaceus (Huangqi) exerts differential angiogenic properties under physiological and pathological conditions

PP.711-777 of this journal issue contain Abstracts of 5th International Meeting on Angiogenesis 2014Poster Presentation I: P-65Physiological angiogenesis requires strict regulation of angiogenic and angiostatic elements inside the body. In some diseased states, for example, cancer, atherosclerosis and retinopathies, this homeostasis is disturbed resulting in the abnormal formation of new blood vessels and thus worsening the conditions of patients. Under both atherosclerotic and cancer conditions, newly formed blood vessels exacerbate the diseases by providing nutrients to assist growth of plaque and tumor, respectively. Therefore, careful usage of traditional Chinese medicine (TCM) is ...postprin

Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?

The search of new anti-inflammatory drugs has been a current preoccupation, due to the need of effective drugs, with less adverse reactions than those used nowadays. Several naphthoquinones (plumbagin, naphthazarin, juglone, menadione, diosquinone and 1,4-naphthoquinone), plus p-hydroquinone and p-benzoquinone were evaluated for their ability to cause a reduction of nitric oxide (NO) production, when RAW 264.7 macrophages were stimulated with lipopolysaccharide (LPS). Dexamethasone was used as positive control. Among the tested compounds, diosquinone was the only one that caused a NO reduction with statistical importance and without cytotoxicity: an IC25 of 1.09±0.24 µM was found, with 38.25±6.50% (p<0.001) NO reduction at 1.5 µM. In order to elucidate if this NO decrease resulted from the interference of diosquinone with cellular defence mechanisms against LPS or to its conversion into peroxynitrite, by reaction with superoxide radical formed by naphthoquinones redox cycling, 3-nitrotyrosine and superoxide determination was also performed. None of these parameters showed significant changes relative to control. Furthermore, diosquinone caused a decrease in the pro-inflammatory cytokines: tumour necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). Therefore, according to the results obtained, diosquinone, studied for its anti-inflammatory potential for the first time herein, has beneficial effects in inflammation control. This study enlightens the mechanisms of action of naphthoquinones in inflammatory models, by checking for the first time the contribution of oxidative stress generated by naphthoquinones to NO reduction