UNDERSTANDING THE EVOLUTION OF INFORMATION SYSTEMS RESEARCH FROM THE PERSPECTIVE OF CO-AUTHORSHIP NETWORK: A COMPREHENSIVE DATA ANALYSIS FROM 1993 TO 2012

Based on the articles published in three top journals in the field of information systems (MISQ, ISR and JMIS) from 1993 to 2012, we conduct a research of the structure, characteristics and development trend of co-authorship network through scientometrics and social network analysis approaches. We gain a number of insights after synthetical analysis. In the last two decades the whole co-authorship network density in information systems faces a tendency of decrease. The co-authorship network presents properties of “small world”. The number of articles published by scholars and institutions in the three elite journals all display a ‘long tail’ phenomenon. The field of information systems has a stable development in the biggest component, and has not yet went into a mature and steady stage. Quite a lot of outstanding scholars and educational resources came from USA, Canada and Hong Kong, and USA has held eight institutions of the top ten. The ranking of an entire institution can be influenced by even one or two authors, indicating that outcome from one level might propagate to the next level

Cardiovascular mortality risk attributable to ambient temperature in China.

OBJECTIVE: To examine cardiovascular disease (CVD) mortality burden attributable to ambient temperature; to estimate effect modification of this burden by gender, age and education level. METHODS: We obtained daily data on temperature and CVD mortality from 15 Chinese megacities during 2007-2013, including 1,936,116 CVD deaths. A quasi-Poisson regression combined with a distributed lag non-linear model was used to estimate the temperature-mortality association for each city. Then, a multivariate meta-analysis was used to derive the overall effect estimates of temperature at the national level. Attributable fraction of deaths were calculated for cold and heat (ie, temperature below and above minimum-mortality temperatures, MMTs), respectively. The MMT was defined as the specific temperature associated to the lowest mortality risk. RESULTS: The MMT varied from the 70th percentile to the 99th percentile of temperature in 15 cities, centring at 78 at the national level. In total, 17.1% (95% empirical CI 14.4% to 19.1%) of CVD mortality (330,352 deaths) was attributable to ambient temperature, with substantial differences among cities, from 10.1% in Shanghai to 23.7% in Guangzhou. Most of the attributable deaths were due to cold, with a fraction of 15.8% (13.1% to 17.9%) corresponding to 305,902 deaths, compared with 1.3% (1.0% to 1.6%) and 24,450 deaths for heat. CONCLUSIONS: This study emphasises how cold weather is responsible for most part of the temperature-related CVD death burden. Our results may have important implications for the development of policies to reduce CVD mortality from extreme temperatures

UNDERSTANDING THE EVOLUTION OF INFORMATION SYSTEMS RESEARCH FROM THE PERSPECTIVE OF CO-AUTHORSHIP NETWORK: A COMPREHENSIVE DATA ANALYSIS FROM 1993 TO 2012

Abstract Based on the articles published in three top journals in the field of information systems (MISQ, ISR and JMIS

Bibliometric and visual analysis of intraoperative hypotension from 2004 to 2022

BackgroundIntraoperative hypotension (IOH) is a common complication occurring in surgical practice. This study aims to comprehensively review the collaboration and impact of countries, institutions, authors, journals, keywords, and critical papers on intraoperative hypotension from the perspective of bibliometric, and to evaluate the evolution of knowledge structure clustering and identify research hotspots and emerging topics.MethodsArticles and reviews related to IOH published from 2004 to 2022 were retrieved from the Web of Science Core Collection. Bibliometric analyses and visualization were conducted on Excel, CiteSpace, VOSviewer, and Bibliometrix (R-Tool of R-Studio).ResultsA total of 1,784 articles and reviews were included from 2004 to 2022. The number of articles on IOH gradually increased in the past few years, and peaked in 2021. These publications were chiefly from 1,938 institutions in 40 countries, led by America and China in publications. Sessler Daniel I published the most papers and enjoyed the highest number of citations. Analysis of the journals with the most outputs showed that most journals concentrated on perioperative medicine and clinical anesthesiology. Delirium, acute kidney injury and vasoconstrictor agents are the current and developing research hotspots. The keywords “Acute kidney injury”, “postoperative complication”, “machine learning”, “risk factors” and “hemodynamic instability” may also become new trends and focuses of the near future research.ConclusionThis study uses bibliometrics and visualization methods to comprehensively review the research on intraoperative hypotension, which is helpful for scholars to better understand the dynamic evolution of IOH and provide directions for future research

Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma

Higher oxidant stress capacity could promote invasion and metastasis. A previous study showed hepatocellular carcinoma (HCC) expressed more Nrf2 than para-carcinoma tissue. The chemotherapeutics such as epirubicin (EPI) could increase Nrf2 expression, while Camptothecin (CPT) could inhibit tumor growth by down-regulating the key molecule of antioxidant stress signal—Nrf2. The role of Nrf2 in invasion and metastasis was still unclear. In this study, we use EPI and CPT to determine the invasion and metastasis in Huh7 cells, H22 and Huh7 mouse models. In Huh7 cells, Nrf2 expression and ROS level were found increased after incubation with EPI by western blot and flow cytometry assay. But with the combination of EPI and CPT, inhibition of Nrf2 could decrease proliferation, invasion, and metastasis, which were investigated by CCK8 assay, wound healing, and Transwell assays. In Huh7 and H22 mouse models, EPI promoted Nrf2 up-regulation and nucleus translocation. Tumor growth was obviously inhibited with a single application of EPI or CPT. The combination of EPI and CPT could inhibit Nrf2 expression but demonstrated more suppressing effect of tumor growth than EPI. Western blot and immunohistochemical staining study revealed that Nrf2 inhibition was beneficial in decreasing the expression of N-cadherin, MMP9, Snail as well as Twist, and increasing E-cadherin, which were associated with epithelial–mesenchymal transition (EMT). Nrf2 down-regulation promoted lung metastasis of H22 cells in vivo. In addition, H&E staining and immunofluorescence staining of VEGFR suggested angiogenesis of Huh7 and H22 tumors was reduced. In conclusion, down-regulation of Nrf2 demonstrated inhibition of invasion, metastasis, and angiogenesis of hepatoma, which may provide a potential therapy in HCC

Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23

Objective: Despite extensive studies, the precise mechanism underlying spondyloarthritis, especially ankylosing spondylitis, remains elusive. This study aimed to develop an ideal animal model for an insight into mechanism of spondyloarthritis and functional relevance of SOCS3 in spondyloarthritis.Methods: Since SOCS3 is a major regulator of IL23-STAT3 signaling, we generated SOCS3 knockdown transgenic (TG) mice for development of an animal model of spondyloarthritis. A hydrodynamic delivery method was employed to deliver minicircle DNA expressing IL23 (mc-IL23) into wild-type (WT) and the TG mice. Knockdown/overexpression systems mediated by lentivirus and retrovirus were used to determine whether SOCS3 regulated osteoblast differentiation.Results: Forced expression of IL23 induced severe joint destruction and extensive bone loss in SOCS3 knockdown TG mice, while this treatment only caused moderate symptoms in WT mice. Furthermore, severe spondyloarthritis was found in IL23-injected TG mice as compared to mild disease observed in WT controls under same condition. Moreover, our studies showed that IL23 promoted osteoblast differentiation via activation of STAT3 pathway and disruption of SOCS3 expression greatly increased phosphorylation of STAT3. In addition, silencing SOCS3 resulted in enhanced osteoblast differentiation through activation of Smad1/5/9 signaling, as evidenced by elevated phosphorylation level of Smad1/5/9. Experiments further demonstrated that SOCS3 interacted with Smad1 and thus suppressed the BMP2-Smad signaling.Conclusions: The results reveal that SOCS3 is involved in IL23-induced spondyloarthritis and acts as a key regulator of osteoblast differentiation, and suggest that SOCS3 knockdown TG mice may be an ideal animal model for further studies of spondyloarthritis

A comprehensive numerical analysis of cross-flow vortex-induced vibrations for top tension risers under different flows

In this paper, the cross-flow vortex-induced vibration (VIV) response of a top tension riser under different flow fields are comprehensively studied using a numerical simulation model based on time domain analysis. A semi-empirical time-domain analysis model that considers the fluid-structure interaction problem in the riser vibration process is proposed and verified by comparison with the previous experimental results. The influence of the flow velocity, the spanwise length of the flow field, and other factors on the VIV amplitude and frequency characteristics of the riser is analyzed in detail. The results show that the VIV response of the riser exhibits obvious multi-modal characteristics, which are accompanied by modal transition, lock-in vibration, synchronous vibration, etc., and the region where the lock-in or synchronous vibration occurs is exactly the region where the crest of the amplitude curve locates. Besides, the VIV intensity of the riser in the stepped flow and uniform flow fields show a tendency of fluctuating increase with the increase of the flow velocity and spanwise length of the flow field, while the VIV intensity of the riser in shear flow is positively correlated with the flow velocity and spanwise length of the flow field. The present study may provide a reference for the prediction of VIV of marine riser in the complex current environment

Carbonate caprock–brine–carbon dioxide interaction : alteration of hydromechanical properties and implications on carbon dioxide leakage

Caprocks play a crucial role in the geological storage of carbon dioxide (CO2) by preventing its escape and thus trapping it into underlying sequestering reservoirs. An evaluation of interaction-induced alteration of the hydromechanical properties of caprocks is essential to better assess the leaking risk and injection-induced rock instability, thus ensuring a long-term viability of geological CO2 storage. We study the changes in minerals, nanopores, elastic velocities, and mechanical responses of a carbonate caprock caused by rock–water/brine–CO2 interaction (CO2 pressure: ≈12 MPa; 50°C). Before the interaction, the total and accessible porosities are 1.6 and 0.6%, respectively, as characterized by the small-angle neutron scattering (SANS) technique. SANS results show that the total porosity of the carbonate caprock increases, apparently because of rock–brine–CO2 interaction, and the increasing rate rises as brine concentration increases (2.2% for 0 M NaCl, 2.6% for 1 M NaCl, and 2.7% for 4 M NaCl). The increase in total porosity is due to the dissolution of calcite, which tends to enlarge accessible pores (by 0.8 to 1.2%) while slightly decreasing the inaccessible pores (by 0.1–0.2%). Under a CO2–acidified water environment, the compressional-wave (P-wave) and shear-wave (S-wave) velocities (5536.7 and 2699.7 m/s) of a core sample containing natural fractures decrease by 8.5 and 8.1%, respectively, whereas both P- and S-wave velocities (6074.1  and 3858.8 m/s) for an intact sample show only ≈0.5% decreases. The interaction also causes more than 50% degradation of the uniaxial compressive strength for the core sample with natural fractures. X-ray microcomputed tomography experiments on three tiny cores (diameter: 1 mm) after 5-day treatment with CO2 (12 MPa) also show that matrix erosion occurs under CO2–acidified water environment but barely occurs without a direct contact with liquid water. Our study suggests that the hydromechanical properties of carbonate caprocks could evolve over the long-term CO2–brine invasion, and it is critical to monitor the CO2–acidified brine interface for a better and long-term evaluation of the caprock integrity

A novel biomimetic sensor system for vibration source perception of autonomous underwater vehicles based on artificial lateral lines

The perception of vibration sources can be used to detect, classify, locate, and track autonomous underwater vehicles (AUVs), which is of great importance for ocean scientific research and naval applications. The artificial lateral lines system (ALLS) is a promising technique to sense underwater vibration sources. However, most current ALLS research focuses on perception mechanism and biomimetic sensor design. The design of a systematic ALLS that is ready for practical applications is still an unsolved problem. To this end, a novel biomimetic sensor system is proposed in this work for the purpose of developing a practical ALLS for AUVs. In order to determine the distribution of the developed biomimetic sensors in the AUVs, hydromechanics modelling and simulation of the artificial lateral lines were implemented to investigate the pressure response mechanisms of the AUVs in terms of the position, frequency and amplitude of the vibration source(s). Subsequently, an experimental AUV was equipped with biomimetic sensors to evaluate the performance of the vibration source perception. Experimental tests were conducted to analyze the relationship between the measured AUV pressure and the distance, frequency and amplitude of the vibration source. Analysis results demonstrate that the experimental measurements were consistent with simulation results. Based on the relationship between the sensor measurements and the vibration source, a neural network model was used to identify the coordinates, frequency and amplitude of the vibration source, producing an identification accuracy of 93%. Hence, the proposed ALLS is effective for vibration source perception of AUVs