Additional file 1 of Health care system costs related to potentially inappropriate medication use involving opioids in older adults in Canada

Additional file 1: Table 1. Costs considered according to the health system perspective [32]

Additional file 1: of Polypharmacy in multimorbid older adults: protocol for a systematic review

Search strategies. Search strategies performed in MEDLINE and Embase. (DOCX 157 kb

Additional file 2: of Polypharmacy in multimorbid older adults: protocol for a systematic review

PRISMA chart. (DOCX 283 kb

Datasheet1_Pain relief and associated factors: a cross-sectional observational web-based study in a Quebec cohort of persons living with chronic pain.pdf

ObjectivesRandomized clinical trials are used to evaluate the efficacy of various pain treatments individually, while a limited number of observational studies have portrayed the overall relief experienced by persons living with chronic pain. This study aimed to describe pain relief in real-world clinical settings and to identify associated factors.MethodsThis exploratory web-based cross-sectional study used data from 1,419 persons recruited in the community. Overall pain relief brought by treatments used by participants was assessed using a 0%–100% scale (10-unit increments).ResultsA total of 18.2% of participants reported minimal pain relief (0%–20%), 60.0% moderate to substantial pain relief (30%–60%), and 21.8% extensive pain relief (70%–100%). Multivariable multinomial regression analysis revealed factors significantly associated with greater pain relief, including reporting a stressful event as circumstances surrounding the onset of pain, living with pain for ≥10 years, milder pain intensity, less catastrophic thinking, use of prescribed pain medications, use of nonpharmacological pain treatments, access to a trusted healthcare professional, higher general health scores, and polypharmacy. Factors associated with lower pain relief included surgery as circumstances surrounding pain onset, use of over-the-counter pain medications, and severe psychological distress.DiscussionIn this community sample of persons living with chronic pain, 8 out of 10 persons reported experiencing at least moderate relief with their treatment. The analysis has enabled us to explore potential modifiable factors as opportunities for improving the well-being of persons living with chronic pain.</p

Effectiveness of an asthma integrated care program on asthma control and adherence to inhaled corticosteroids

<div><p></p><p><i>Objective</i>: To measure the effectiveness of an integrated care program for individuals with asthma aged 12–45 years, on asthma control and adherence to inhaled corticosteroids (ICS). <i>Methods</i>: Researchers used a theoretical model to develop the program and assessed effectiveness at 12 months, using a pragmatic controlled clinical trial design. Forty-two community pharmacists in Quebec, Canada recruited participants with either uncontrolled or mild-to-severe asthma. One group was exposed to the program; another received usual care. Asthma control was measured with the Asthma Control Questionnaire; ICS adherence was assessed with the Morisky medication adherence scale and the medication possession ratio. Program effectiveness was assessed with an intention-to-treat approach using multivariate generalized estimating equation models. <i>Results</i>: Among 108 exposed and 241 non-exposed, 52.2% had controlled asthma at baseline. At 12-months, asthma control had improved in both groups but the interaction between study groups and time was not significant (<i>p</i> = 0.09). The proportion of participants with good ICS adherence was low at baseline. Exposed participants showed improvement in adherence and the interaction between study groups and time was significant (<i>p</i> = 0.02). <i>Conclusion</i>: An integrated intervention, with healthcare professionals collaborating to optimize asthma control, can improve ICS adherence.</p></div