12 research outputs found
Genetic basis of IgE responsiveness: relevance to the atopic diseases
No full textGenetic analysis of 170 subjects in 11 extended Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum IgE levels. No linkage was found between these markers and specific IgE antibody levels. Analysis of total IgE within a subset of 128 IgE-antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p = 4 Ă— 10--6). These and other data suggest that IL4 or a nearby gene regulates IgE production in a non-antigen-specific (noncognate) fashion and provide evidence for a possible link between asthma and the IL4 gene
Testing for gene-gene interaction controlling total IgE in families from Barbados: evidence of sensitivity regarding linkage heterogeneity among families
No full textLinkage analysis of Dermatophagoides pteronyssinus–specific IgE responsiveness with polymorphic markers on chromosome 6p21 (HLA-D region) in Caucasian families by the transmission/disequilibrium test
No full textGenetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families
No full textEvidence for linkage of chemokine polymorphisms to asthma in populations of African descent
No full textInteraction between loci on chromosomes 12q and 17q increases susceptibility to elevated total IgE in two distinct populations
No full textAtopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES
No full textGenetic regulation of Dermatophagoides pteronyssinus–specific IgE responsiveness: A genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs
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