The star formation history of RCW 36

Recent studies of massive-star forming regions indicate that they can contain multiple generations of young stars. These observations suggest that star formation in these regions is sequential and/or triggered by a previous generation of (massive) stars. Here we present new observations of the star forming region RCW 36 in the Vela Molecular Ridge, hosting a young cluster of massive stars embedded in a molecular cloud complex. In the periphery of the cluster several young stellar objects (YSOs) are detected which produce bipolar jets (HH 1042 and HH 1043) demonstrating that these objects are still actively accreting. The VLT/X-shooter spectrum of the jet structure of HH 1042 provides detailed information on the physical conditions and kinematical properties of the jet plasma. From this information the YSO's accretion history can be derived. Combining the photometric and spectroscopic observations of RCW 36 gives insight into the formation process of individual stars and the star formation history of this young massive-star forming region.Comment: 10 pages, 5 figures, to appear in the proceedings of the ESO workshop "Circumstellar Dynamics at High Resolution", Foz do Iguacu (Br), Feb 2012, eds. A. Carciofi and T. Riviniu

An Examination of the Effectiveness of an 8-Week Bikram Yoga Program on Mindfulness, Perceived Stress, and Physical Fitness

Previous research reports positive effects of yoga on health. The physical and psychological outcomes of participation in Bikram yoga are under-researched despite its increasing popularity, and this type of yoga may be significant with regards to stress management due to its unique method of practice. This study was designed to assess changes in levels of mindfulness, perceived stress, and physical fitness after participation in an 8-week Bikram yoga program. Fifty-one participants aged 20–54 years (mean, 31.57 years) were recruited by word of mouth from a large university located in the Northwestern United States. Participants attended a minimum of 20 Bikram sessions over 8 weeks. Changes in mindfulness (Five-Facet Mindfulness Questionnaire), perceived stress (Perceived Stress Scale), and physical fitness (resting heart rate, 1-mile walk, sit-and-reach, total-body rotation, and single-leg balance) were measured. Eight weeks of Bikram yoga improved mindfulness, perceived stress, cardiorespiratory endurance, flexibility and balance (p \u3c 0.01). Mindfulness was negatively correlated with perceived stress (r=−0.43, p \u3c 0.01) and resting heart rate (r=−0.30, p \u3c 0.05). The results show that Bikram yoga positively affected psychological and physical health in the sample population. This information can be used to further the understanding of mind-body based programs, and how Bikram yoga may give people the tools to decrease perceived stress, potentially having an effect on chronic stress-related illnesses

An Examination of Current Practices and Gender Differences in Strength and Conditioning in a Sample of Varsity High School Athletic Programs

Currently, little is known about strength and conditioning programs at the high school level. Therefore, the purpose of this research was to explore current practices in strength and conditioning for varsity high school athletes in selected sports. Specifically examined were: who administers programs for these athletes, what kinds of training activities are done, and whether the responsible party or emphasis changes depending on the gender of the athletes. Coaches of varsity soccer, basketball, and softball/baseball in three large Idaho school districts were asked to complete an online survey. Sixty-seven percent (32/48) of the questionnaires were completed and used for the study. The majority of coaches (84%) provided strength and conditioning opportunities for their athletes, although only 37% required participation. Strength training programs were designed and implemented primarily by either physical education (PE) teachers or head coaches. Compared to coaches of male athletes, coaches of female athletes were less likely to know the credentials of their strength coaches, and they were less likely to use certified coaches to plan and implement their strength and conditioning programs. Most programs included dynamic warm-ups and cool-downs, plyometrics, agility training, speed training, and conditioning, and most programs were conducted three days a week (76%) for sessions lasting between 30 and 59 minutes (63%). Compared to their female counterparts, male athletes were more likely to have required training, participate in strength training year round, and train using more sessions per week. This study provides additional information related to the practice of strength and conditioning in a sample of high school athletic teams

Canonical and Non-Canonical Roles of GRK2 in Lymphocytes

G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative signaling node in a variety of biological processes ranging from cell growth and proliferation to migration and chemotaxis. As such, GRK2 is now implicated as playing a role in the molecular pathogenesis of a broad group of diseases including heart failure, cancer, depression, neurodegenerative disease, and others. In addition to its long-known canonical role in the phosphorylation and desensitization of G protein-coupled receptors (GPCRs), recent studies have shown that GRK2 also modulates a diverse array of other molecular processes via newly identified GRK2 kinase substrates and via a growing number of protein-protein interaction binding partners. GRK2 belongs to the 7-member GRK family. It is a multidomain protein containing a specific N-terminal region (referred to as αN), followed by a regulator of G protein signaling homology (RH) domain, an AGC (Protein kinase A, G, C serine/threonine kinase family) kinase domain, and a C-terminal pleckstrin homology (PH) domain. GPCRs mediate the activity of many regulators of the immune system such as chemokines and leukotrienes, and thus GRK proteins may play key roles in modulating the lymphocyte response to these factors. As one of the predominant GRK family members expressed in immune cells, GRK2′s canonical and noncanonical actions play an especially significant role in normal immune cell function as well as in the development and progression of disorders of the immune system. This review summarizes our current state of knowledge of the roles of GRK2 in lymphocytes. We highlight the diverse functions of GRK2 and discuss how ongoing investigation of GRK2 in lymphocytes may inform the development of new therapies for diseases associated with lymphocyte dysregulation

Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.

MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell receptor signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the recurrent t(11;18)(q21;q21) aberration, which is the most frequent translocation in mucosa-associated lymphoid tissue (MALT) lymphoma. API2-MALT1-positive MALT lymphomas manifest antibiotic resistance and aggressive clinical behaviour with poor clinical outcome. However, the mechanisms underlying API2-MALT1-induced MALT lymphomagenesis are not fully understood. Here we show that API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor protein LIMA1. LIMA1 binding by API2-MALT1 is API2 dependent and proteolytic cleavage is dependent on MALT1 paracaspase activity. Intriguingly, API2-MALT1-mediated proteolysis generates a LIM domain-only (LMO)-containing fragment with oncogenic properties in vitro and in vivo. Importantly, primary MALT lymphomas harbouring the API2-MALT1 fusion uniquely demonstrate LIMA1 cleavage fragments. Our studies reveal a novel paracaspase-mediated oncogenic gain-of-function mechanism in the pathogenesis of MALT lymphoma.This work was supported in part by NIH grants R01 DE119249 and R01 CA136905 (K.S.J.E-J.), R01 CA140806 (M.S.L.) and the Department of Pathology at the University of Michigan.This is the accepted manuscript. The final version is available from Nature at http://www.nature.com/ncomms/2015/150108/ncomms6908/full/ncomms6908.html

Higher physical fitness levels are associated with less language decline in healthy ageing

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E-health and M-health in Bangladesh: Opportunities and Challenges

There is growing enthusiasm amongst analysts of global health for the possibilities opened up by the rapid spread of mobile phone coverage. This includes substantially increasing access to health-related information and advice and to expert medical consultations. Some argue we are reaching a tipping point in the organisation of health systems in which new technology will drive new organisational arrangements (Christensen, Grossman and Hwang 2009; Bloom and Standing 2008). This is encouraging investment by foundations and bilateral aid agencies in the development of e-health and m-health as a way to improve access to health services in low- and middle-income countries. As with the introduction and spread of any new technology, there are a number of possible outcomes – or pathways – with different implications for the types of service provided and the distribution of benefits in the short and longer term. A recent STEPS Centre publication (2010) proposes the following characteristics of the way a technological innovation is spread: the direction of development and the way organisations incorporate the new technology into their operations; the distribution of benefits from the technology and the diversity of ways the technology is applied. It argues that the actual pathway of development is strongly influenced by political processes, involving a number of stakeholders with differing interests and understandings. A number of analysts argue that health systems are particularly path-dependent because of the importance that people give to arrangements they believe protect them from serious health problems (Bloom and Standing 2008). Lee and Lansky (2008), for example, suggest that resistance by stakeholders and complex regulatory barriers are substantially diminishing the impact of new technologies on the organisation of the American health system. Because of the path-dependent nature of the health sector, decisions made early in the emergence of a new technology are likely to have a strong and lasting influence (Bloom and Wolcott 2013). This report presents a snapshot of how information and communication technologies (ICTs) are influencing health system development in Bangladesh.UK Department for International Developmen

Training for the HandbikeBattle:an explorative analysis of training load and handcycling physical capacity in recreationally active wheelchair users

Purpose: (1) to analyze training characteristics of recreationally active wheelchair users during handcycle training, and (2) to examine the associations between training load and change in physical capacity. Methods: Former rehabilitation patients (N = 60) with health conditions such as spinal cord injury or amputation were included. Participants trained for five months. A handcycling/arm crank graded exercise test was performed before and after the training period. Outcomes: peak power output per kg (POpeak/kg) and peak oxygen uptake per kg (VO 2peak/kg). Training load was defined as Training Impulse (TRIMP), which is rating of perceived exertion (sRPE) multiplied by duration of the session, in arbitrary units (AU). Training intensity distribution (TID) was also determined (time in zone 1, RPE ≤4; zone 2, RPE 5–6; zone 3, RPE ≥7). Results: Multilevel regression analyses showed that TRIMP sRPE was not significantly associated with change in physical capacity. Time in zone 2 (RPE 5–6) was significantly associated with ΔVO 2peak, %ΔVO 2peak, ΔVO 2peak/kg and %ΔVO 2peak/kg. Conclusion: Training at RPE 5–6 was the only determinant that was significantly associated with improvement in physical capacity. Additional controlled studies are necessary to demonstrate causality and gather more information about its usefulness, and optimal handcycle training regimes for recreationally active wheelchair users.IMPLICATIONS FOR REHABILITATION Monitoring of handcycle training load is important to structure the training effort and intensity over time and to eventually optimize performance capacity. This is especially important for relatively untrained wheelchair users, who have a low physical capacity and a high risk of overuse injuries and shoulder pain. Training load can be easily calculated by multiplying the intensity of the training (RPE 0–10) with the duration of the training in minutes. Results on handcycle training at RPE 5–6 intensity in recreationally active wheelchair users suggests to be promising and should be further investigated with controlled studies